HitPredict

Interactor 1: DKC1 (O60832)
H/ACA ribonucleoprotein complex subunit DKC1 (EC 5.4.99.-) (CBF5 homolog) (Dyskerin) (Nopp140-associated protein of 57 kDa) (Nucleolar protein NAP57) (Nucleolar protein family A member 4) (snoRNP protein DKC1)
Gene: DKC1

Interactor 2: RUVB2 (Q9Y230)
RuvB-like 2 (EC 3.6.4.12) (48 kDa TATA box-binding protein-interacting protein) (48 kDa TBP-interacting protein) (51 kDa erythrocyte cytosolic protein) (ECP-51) (INO80 complex subunit J) (Repressing pontin 52) (Reptin 52) (TIP49b) (TIP60-associated protein 54-beta) (TAP54-beta)
Gene: RUVBL2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.748

Property	Details
Experiments	28561026, 35271311, 18358808, 26186194, 28514442, 33961781, 19179534
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:1904874 - positive regulation of telomerase RNA localization to Cajal body
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 514 Hs			1 463
+	Hs
		242606 DKC1_HUMAN (1-514): 0: 779: 100.00		RUVB1_HUMAN (8-451): 0: 655: 42.67
+	Sc
		704456 CBF5_YEAST (33-472): 0: 633: 63.17		RUVB2_YEAST (7-451): 0: 650: 68.76
+	Sc
		704415 CBF5_YEAST (33-472): 0: 633: 63.17		RUVB1_YEAST (12-451): 0: 605: 41.72