HitPredict

Interactor 1: DIAP2 (O60879)
Protein diaphanous homolog 2 (Diaphanous-related formin-2) (DRF2)
Gene: DIAPH2

Interactor 2: PROF1 (P07737)
Profilin-1 (Epididymis tissue protein Li 184a) (Profilin I)
Gene: PFN1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	34079125, 35271311
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003779 - actin binding GO:0005829 - cytosol GO:0031267 - small GTPase binding
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 1101 Hs			1 140
+	Hs
		430352 DIAP3_HUMAN (13-1093): 0: 886: 56.56		PROF1_HUMAN (1-140): 1.1e-77: 227: 100.00
+	Hs
		430307 FMNL2_HUMAN (91-1091): 0: 651: 22.60		PROF1_HUMAN (1-140): 1.1e-77: 227: 100.00
+	Hs
		314830 FMNL1_HUMAN (30-1078): 0: 563: 19.45		PROF1_HUMAN (1-140): 1.1e-77: 227: 100.00
+	Hs
		314847 FMNL1_HUMAN (30-1078): 0: 563: 19.45		PROF2_HUMAN (1-140): 1.13e-74: 220: 61.43
+	Hs
		430404 FHOD1_HUMAN (173-1076): 9.99e-158: 500: 15.55		PROF1_HUMAN (1-140): 1.1e-77: 227: 100.00
+	Hs
		715022 FHOD1_HUMAN (173-1076): 9.99e-158: 500: 15.55		PROF2_HUMAN (1-140): 1.13e-74: 220: 61.43
+	Hs
		237549 DIAP1_HUMAN (1-626): 7.15e-126: 417: 42.10		PROF1_HUMAN (1-140): 1.1e-77: 227: 100.00
+	Hs
		237564 DIAP1_HUMAN (1-626): 7.15e-126: 417: 42.10		PROF2_HUMAN (1-140): 1.13e-74: 220: 61.43
+	Hs
		430197 INF2_HUMAN (604-1100): 3.15e-111: 377: 23.61		PROF1_HUMAN (1-140): 1.1e-77: 227: 100.00
+	Hs
		714970 INF2_HUMAN (604-1100): 3.15e-111: 377: 23.61		PROF2_HUMAN (1-140): 1.13e-74: 220: 61.43
+	Hs
		430356 FMN2_HUMAN (577-1053): 2.63e-98: 345: 23.65		PROF1_HUMAN (1-140): 1.1e-77: 227: 100.00