Protein: EXOSX
Exosome complex component 10 (EC 3.1.13.-) (Autoantigen PM/Scl 2) (P100 polymyositis-scleroderma overlap syndrome-associated autoantigen) (Polymyositis/scleroderma autoantigen 100 kDa) (PM/Scl-100) (Polymyositis/scleroderma autoantigen 2)

Gene: EXOSX, EXOSC10
Organism: Homo sapiens
Interactions: 224
UniProt ID: Q01780

Gene Ontology (top 5):
GO:0000166 - nucleotide binding
GO:0000175 - 3'-5'-RNA exonuclease activity
GO:0000176 - nuclear exosome (RNase complex)
GO:0000177 - cytoplasmic exosome (RNase complex)
GO:0000178 - exosome (RNase complex)

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1032254

EXOS3
Exosome complex component RRP40

8

2

Small-scale

0.968

High

1032160

C1D
Nuclear nucleic acid-binding protein C1D

5

0

Small-scale

0.887

High

1032145

EXOSX
Exosome complex component 10

3

5

Small-scale

0.812

High

838700

MTREX
Exosome RNA helicase MTR4

2

5

High-throughput

0.754

High

1032251

EXOS4
Exosome complex component RRP41

8

11

Small-scale

0.752

High

1032167

EXOS7
Exosome complex component RRP42

8

12

Small-scale

0.748

High

1032215

EXOS8
Exosome complex component RRP43

8

12

Small-scale

0.748

High

1032253

EXOS5
Exosome complex component RRP46

7

12

Small-scale

0.747

High

1032273

EXOS1
Exosome complex component CSL4

7

8

Small-scale

0.745

High

1032159

EXOS2
Exosome complex component RRP4

6

5

Small-scale

0.727

High

1032225

MPH6
M-phase phosphoprotein 6

7

0

Small-scale

0.711

High

1032150

EXOS9
Exosome complex component RRP45

5

13

Small-scale

0.706

High

1032278

RBM7
RNA-binding protein 7

4

2

High-throughput

0.694

High

1032271

RRP44
Exosome complex exonuclease RRP44

4

5

Small-scale

0.687

High

1032178

EXOS6
Exosome complex component MTR3

4

13

Small-scale

0.674

High

1032191

ZCH18
Zinc finger CCCH domain-containing protein 18

3

2

High-throughput

0.667

High

1032203

DI3L1
DIS3-like exonuclease 1

3

5

Small-scale

0.667

High

1032172

SKI2
Superkiller complex protein 2

1

4

High-throughput

0.656

High

1032173

IF16
Gamma-interferon-inducible protein 16

3

2

High-throughput

0.656

High

315477

RECQ4
ATP-dependent DNA helicase Q4

1

6

High-throughput

0.618

High

1032236

DDX24
ATP-dependent RNA helicase DDX24

1

1

High-throughput

0.618

High

371795

MYC
Myc proto-oncogene protein

3

0

High-throughput

0.613

High

964227

SUMO2
Small ubiquitin-related modifier 2

2

4

High-throughput

0.602

High

446919

NPM
Nucleophosmin

2

0

High-throughput

0.602

High

608552

DDX5
Probable ATP-dependent RNA helicase DDX5

1

0

Small-scale

0.586

High

1032165

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

0

High-throughput

0.586

High

241430

PRKN
E3 ubiquitin-protein ligase parkin

2

2

High-throughput

0.584

High

259813

BRD4
Bromodomain-containing protein 4

2

1

High-throughput

0.584

High

272086

OBSL1
Obscurin-like protein 1

2

2

High-throughput

0.584

High

588492

RFA2
Replication protein A 32 kDa subunit

2

1

High-throughput

0.584

High

695241

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

3

High-throughput

0.584

High

767983

RFA3
Replication protein A 14 kDa subunit

2

1

High-throughput

0.584

High

978878

RS6
Small ribosomal subunit protein eS6

2

1

High-throughput

0.584

High

1032248

RENT2
Regulator of nonsense transcripts 2

2

0

Small-scale

0.575

High

775020

FUS
RNA-binding protein FUS

2

2

High-throughput

0.571

High

1032183

ZCHC8
Zinc finger CCHC domain-containing protein 8

2

0

High-throughput

0.559

High

1032234

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

2

0

High-throughput

0.559

High

1032238

AICDA
Single-stranded DNA cytosine deaminase

2

0

Small-scale

0.559

High

1032261

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

0

High-throughput

0.554

High

1032206

TITIN
Titin

1

2

High-throughput

0.541

High

191611

MAGB2
Melanoma-associated antigen B2

1

1

High-throughput

0.536

High

395933

ESR1
Estrogen receptor

1

6

High-throughput

0.536

High

655158

SFPQ
Splicing factor, proline- and glutamine-rich

1

2

High-throughput

0.536

High

833096

MNDA
Myeloid cell nuclear differentiation antigen

1

2

High-throughput

0.536

High

849144

KSYK
Tyrosine-protein kinase SYK

1

1

High-throughput

0.536

High

969798

RS16
Small ribosomal subunit protein uS9

1

1

High-throughput

0.536

High

992692

RACK1
Small ribosomal subunit protein RACK1

1

7

High-throughput

0.536

High

1027387

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

2

High-throughput

0.536

High

1032149

FAK1
Focal adhesion kinase 1

1

2

High-throughput

0.536

High

1032158

CUL3
Cullin-3

1

2

High-throughput

0.536

High

1032192

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

1

High-throughput

0.536

High

1032204

PSPC1
Paraspeckle component 1

1

2

High-throughput

0.536

High

1032223

CDC5L
Cell division cycle 5-like protein

1

1

High-throughput

0.536

High

1032270

DRG1
Developmentally-regulated GTP-binding protein 1

1

2

High-throughput

0.536

High

830585

CCNF
Cyclin-F

1

1

High-throughput

0.515

High

624034

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

0

High-throughput

0.513

High

785109

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.513

High

859234

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.513

High

908380

HDGF
Hepatoma-derived growth factor

1

0

High-throughput

0.513

High

960691

RL15
Large ribosomal subunit protein eL15

1

0

High-throughput

0.513

High

1032148

RL18A
Large ribosomal subunit protein eL20

1

0

High-throughput

0.513

High

1032157

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.513

High

1032267

SRPK3
SRSF protein kinase 3

1

0

High-throughput

0.513

High

1032281

OAS3
2'-5'-oligoadenylate synthase 3

1

0

High-throughput

0.513

High

1032152

SSRP1
FACT complex subunit SSRP1

1

2

High-throughput

0.508

High

1032156

TADBP
TAR DNA-binding protein 43

1

2

High-throughput

0.508

High

1032171

NOMO1
BOS complex subunit NOMO1

1

1

High-throughput

0.508

High

1032214

RPE
Ribulose-phosphate 3-epimerase

1

1

High-throughput

0.508

High

1032217

FXRD1
FAD-dependent oxidoreductase domain-containing protein 1

1

1

High-throughput

0.508

High

1032239

XRN2
5'-3' exoribonuclease 2

1

2

High-throughput

0.508

High

1032211

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

1

High-throughput

0.501

High

305836

DXO
Decapping and exoribonuclease protein

1

0

High-throughput

0.486

High

344534

LSM8
U6 snRNA-associated Sm-like protein LSm8

1

0

High-throughput

0.486

High

1032161

SCRIB
Protein scribble homolog

1

0

High-throughput

0.486

High

1032187

EIF3M
Eukaryotic translation initiation factor 3 subunit M

1

0

High-throughput

0.486

High

1032189

URP2
Fermitin family homolog 3

1

0

High-throughput

0.486

High

1032197

CHSS2
Chondroitin sulfate synthase 2

1

0

High-throughput

0.486

High

1032227

CIB1
Calcium and integrin-binding protein 1

1

0

High-throughput

0.486

High

1032245

PGES2
Prostaglandin E synthase 2

1

0

High-throughput

0.486

High

1032263

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

0

High-throughput

0.486

High

1032268

B9D1
B9 domain-containing protein 1

1

0

High-throughput

0.486

High

1032269

RUVB2
RuvB-like 2

1

0

High-throughput

0.486

High

1032272

LSM2
U6 snRNA-associated Sm-like protein LSm2

1

0

High-throughput

0.486

High

318475

TOX4
TOX high mobility group box family member 4

1

4

High-throughput

0.481

High

722698

AL1B1
Aldehyde dehydrogenase X, mitochondrial

1

2

High-throughput

0.481

High

1032174

MIC60
MICOS complex subunit MIC60

1

1

High-throughput

0.481

High

1032198

XRN1
5'-3' exoribonuclease 1

1

2

High-throughput

0.481

High

1032260

PALS2
Protein PALS2

1

1

High-throughput

0.481

High

1032280

UBP16
Ubiquitin carboxyl-terminal hydrolase 16

1

3

High-throughput

0.481

High

131965

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

1

High-throughput

0.479

High

140576

MPP10
U3 small nucleolar ribonucleoprotein protein MPP10

1

3

High-throughput

0.479

High

188479

NVL
Nuclear valosin-containing protein-like

1

3

High-throughput

0.479

High

190875

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

2

High-throughput

0.479

High

215297

TXNL1
Thioredoxin-like protein 1

1

2

High-throughput

0.479

High

244678

ZC3H1
Zinc finger C3H1 domain-containing protein

1

1

High-throughput

0.479

High

291087

UTP20
Small subunit processome component 20 homolog

1

1

High-throughput

0.479

High

293579

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.479

High

400673

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.479

High

413650

P53
Cellular tumor antigen p53

1

1

High-throughput

0.479

High

472658

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

2

High-throughput

0.479

High

519954

ANDR
Androgen receptor

1

6

High-throughput

0.479

High

558053

XRCC6
X-ray repair cross-complementing protein 6

1

4

High-throughput

0.479

High

606648

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

620304

NUCL
Nucleolin

1

2

High-throughput

0.479

High

711098

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

2

High-throughput

0.479

High

731211

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.479

High

799004

BRCA1
Breast cancer type 1 susceptibility protein

1

5

High-throughput

0.479

High

846246

MATR3
Matrin-3

1

1

High-throughput

0.479

High

862049

YAP1
Transcriptional coactivator YAP1

1

3

High-throughput

0.479

High

872214

SOX2
Transcription factor SOX-2

1

3

High-throughput

0.479

High

904612

MECP2
Methyl-CpG-binding protein 2

1

1

High-throughput

0.479

High

907384

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

3

High-throughput

0.479

High

911216

IMA5
Importin subunit alpha-5

1

1

High-throughput

0.479

High

914939

THOP1
Thimet oligopeptidase

1

1

High-throughput

0.479

High

929903

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

2

High-throughput

0.479

High

964859

WDR5
WD repeat-containing protein 5

1

4

High-throughput

0.479

High

970355

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

979519

H4
Histone H4

1

1

High-throughput

0.479

High

980702

H2B1C
Histone H2B type 1-C/E/F/G/I

1

1

High-throughput

0.479

High

984720

RL31
Large ribosomal subunit protein eL31

1

2

High-throughput

0.479

High

998223

H31
Histone H3.1

1

2

High-throughput

0.479

High

1004323

NOP14
Nucleolar protein 14

1

1

High-throughput

0.479

High

1008686

RED1
Double-stranded RNA-specific editase 1

1

4

High-throughput

0.479

High

1032153

ARL16
ADP-ribosylation factor-like protein 16

1

5

High-throughput

0.479

High

1032154

TBL3
Transducin beta-like protein 3

1

6

High-throughput

0.479

High

1032155

NFX1
Transcriptional repressor NF-X1

1

1

High-throughput

0.479

High

1032164

BMS1
Ribosome biogenesis protein BMS1 homolog

1

3

High-throughput

0.479

High

1032168

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

1032169

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.479

High

1032170

WDR43
WD repeat-containing protein 43

1

9

High-throughput

0.479

High

1032177

TDIF2
Deoxynucleotidyltransferase terminal-interacting protein 2

1

1

High-throughput

0.479

High

1032181

RC3H1
Roquin-1

1

1

High-throughput

0.479

High

1032182

IFIX
Pyrin and HIN domain-containing protein 1

1

2

High-throughput

0.479

High

1032185

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

1032188

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

1032194

WDR75
WD repeat-containing protein 75

1

8

High-throughput

0.479

High

1032196

SLX4
Structure-specific endonuclease subunit SLX4

1

2

High-throughput

0.479

High

1032199

SIR6
NAD-dependent protein deacylase sirtuin-6

1

4

High-throughput

0.479

High

1032200

PAPD5
Terminal nucleotidyltransferase 4B

1

5

High-throughput

0.479

High

1032201

WDR36
WD repeat-containing protein 36

1

7

High-throughput

0.479

High

1032205

DNJC9
DnaJ homolog subfamily C member 9

1

1

High-throughput

0.479

High

1032207

TOPB1
DNA topoisomerase 2-binding protein 1

1

1

High-throughput

0.479

High

1032210

RENT1
Regulator of nonsense transcripts 1

1

6

Small-scale

0.479

High

1032212

FBXW7
F-box/WD repeat-containing protein 7

1

2

High-throughput

0.479

High

1032213

UTP4
U3 small nucleolar RNA-associated protein 4 homolog

1

6

High-throughput

0.479

High

1032219

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.479

High

1032220

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

1032222

RANB9
Ran-binding protein 9

1

1

High-throughput

0.479

High

1032224

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

1

High-throughput

0.479

High

1032229

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

2

High-throughput

0.479

High

1032230

RIOK1
Serine/threonine-protein kinase RIO1

1

2

High-throughput

0.479

High

1032231

NOC4L
Nucleolar complex protein 4 homolog

1

3

High-throughput

0.479

High

1032232

UT14A
U3 small nucleolar RNA-associated protein 14 homolog A

1

1

High-throughput

0.479

High

1032237

WWTR1
WW domain-containing transcription regulator protein 1

1

3

High-throughput

0.479

High

1032242

ZN106
Zinc finger protein 106

1

4

High-throughput

0.479

High

1032243

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

1032244

HEAT1
HEAT repeat-containing protein 1

1

1

High-throughput

0.479

High

1032249

RC3H2
Roquin-2

1

3

High-throughput

0.479

High

1032250

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

1

High-throughput

0.479

High

1032252

BRD7
Bromodomain-containing protein 7

1

1

High-throughput

0.479

High

1032256

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

4

High-throughput

0.479

High

1032257

ARL8B
ADP-ribosylation factor-like protein 8B

1

2

High-throughput

0.479

High

1032262

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1032264

HECD1
E3 ubiquitin-protein ligase HECTD1

1

3

High-throughput

0.479

High

1032266

WDR3
WD repeat-containing protein 3

1

8

High-throughput

0.479

High

1032277

HBS1L
HBS1-like protein

1

2

High-throughput

0.479

High

128983

MEN1
Menin

1

0

High-throughput

0.458

High

157256

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

182973

NKRF
NF-kappa-B-repressing factor

1

0

High-throughput

0.458

High

252047

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.458

High

319684

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

464915

SP1
Transcription factor Sp1

1

0

High-throughput

0.458

High

643790

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

High-throughput

0.458

High

906503

PSMD7
26S proteasome non-ATPase regulatory subunit 7

1

0

High-throughput

0.458

High

937717

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.458

High

982626

RS24
Small ribosomal subunit protein eS24

1

0

High-throughput

0.458

High

1032146

PO5F1
POU domain, class 5, transcription factor 1

1

0

High-throughput

0.458

High

1032166

MTF1
Metal regulatory transcription factor 1

1

0

High-throughput

0.458

High

1032176

PCID2
PCI domain-containing protein 2

1

0

High-throughput

0.458

High

1032184

GGYF2
GRB10-interacting GYF protein 2

1

0

High-throughput

0.458

High

1032190

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1032195

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

1032202

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1032208

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

1032216

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

1032221

LENG8
Leukocyte receptor cluster member 8

1

0

High-throughput

0.458

High

1032226

M3K14
Mitogen-activated protein kinase kinase kinase 14

1

0

High-throughput

0.458

High

1032228

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.458

High

1032233

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

1032241

REN3A
Regulator of nonsense transcripts 3A

1

0

Small-scale

0.458

High

1032246

NANOG
Homeobox protein NANOG

1

0

High-throughput

0.458

High

1032255

ANLN
Anillin

1

0

High-throughput

0.458

High

1032258

SDA1
Protein SDA1 homolog

1

0

High-throughput

0.458

High

1032259

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1032265

CC14A
Dual specificity protein phosphatase CDC14A

1

0

High-throughput

0.458

High

1032274

RRP15
RRP15-like protein

1

0

High-throughput

0.458

High

1032275

RNF11
RING finger protein 11

1

0

Small-scale

0.458

High

1032276

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

1032279

RBM8A
RNA-binding protein 8A

1

0

High-throughput

0.458

High

429747

JUN
Transcription factor Jun

1

2

High-throughput

0.445

High

529653

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.445

High

1032163

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

1

High-throughput

0.445

High

1032209

ESR2
Estrogen receptor beta

1

6

High-throughput

0.445

High

1032235

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.445

High

1032175

NOMO2
BOS complex subunit NOMO2

1

1

High-throughput

0.439

High

1032180

MF14B
Hippocampus abundant transcript-like protein 1

1

0

High-throughput

0.438

High

411758

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.437

High

720194

UFO
Tyrosine-protein kinase receptor UFO

1

1

High-throughput

0.437

High

1032218

RN185
E3 ubiquitin-protein ligase RNF185

1

4

High-throughput

0.437

High

327952

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

0

High-throughput

0.426

High

1032147

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

0

High-throughput

0.426

High

1032151

FMR1
Fragile X messenger ribonucleoprotein 1

1

0

High-throughput

0.426

High

1032179

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

1032193

S2611
Sodium-independent sulfate anion transporter

1

0

High-throughput

0.426

High

1032240

MAGT1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1

1

0

High-throughput

0.426

High

1032247

LN28A
Protein lin-28 homolog A

1

0

High-throughput

0.426

High

886769

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.408

High

657224

KALM
Anosmin-1

1

0

High-throughput

0.279

Low

405219

LCAT
Phosphatidylcholine-sterol acyltransferase

1

0

High-throughput

0.251

Low

590880

TIMP2
Metalloproteinase inhibitor 2

1

0

High-throughput

0.249

Low

787005

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

0

High-throughput

0.249

Low

1032162

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.249

Low

1032186

UBP53
Ubiquitin carboxyl-terminal hydrolase 53

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025