HitPredict

Interactor 1: SH21A (O60880)
SH2 domain-containing protein 1A (Duncan disease SH2-protein) (Signaling lymphocytic activation molecule-associated protein) (SLAM-associated protein) (T-cell signal transduction molecule SAP)
Gene: SH2D1A

Interactor 2: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.726

Property	Details
Experiments	24688028, 15096483
Identification Methods	anti bait coimmunoprecipitation, two hybrid
Interaction Type	association, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~SH3_1
Common GO terms	GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 128 Hs			1 509
+	Hs
		411559 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		LCK_HUMAN (1-509): 0: 661: 100.00
+	Hs
		442759 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		HCK_HUMAN (1-509): 0: 602: 65.04
+	Mm
		435875 HCK_MOUSE (1-127): 9.56e-42: 145: 19.55		HCK_MOUSE (1-509): 0: 590: 63.99
+	Hs
		442772 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		SRC_HUMAN (20-507): 0: 586: 55.00
+	Hs
		412070 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		FYN_HUMAN (30-507): 0: 586: 59.01
+	Hs
		522840 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		SRC_HUMAN (20-507): 0: 586: 55.00
+	Hs
		337307 ABL1_HUMAN (1-127): 4.39e-40: 143: 26.72		FYN_HUMAN (30-507): 0: 586: 59.01
+	Hs
		337329 ABL1_HUMAN (1-127): 4.39e-40: 143: 26.72		SRC_HUMAN (20-507): 0: 586: 55.00
+	Hs
		433530 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		LYN_HUMAN (1-509): 0: 582: 62.72
+	Hs
		337315 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21
+	Hs
		337384 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21
+	Hs
		337293 ABL1_HUMAN (1-127): 4.39e-40: 143: 26.72		ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21
+	Mm
		337615 ABL1_MOUSE (1-127): 5.17e-40: 143: 26.72		ABL1_MOUSE (49-502): 5.34e-171: 513: 42.21
+	Hs
		442789 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		ABL2_HUMAN (57-502): 3.29e-166: 502: 42.95
+	Hs
		789042 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		ABL2_HUMAN (57-502): 3.29e-166: 502: 42.95
+	Hs
		442813 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		BTK_HUMAN (7-505): 1.49e-167: 490: 33.27
+	Hs
		337440 ABL1_HUMAN (1-127): 4.39e-40: 143: 26.72		BTK_HUMAN (7-505): 1.49e-167: 490: 33.27