Protein: TRM1L
tRNA (guanine(27)-N(2))-dimethyltransferase (EC 2.1.1.-) (tRNA methyltransferase 1-like protein) (TRMT1-like protein)

Gene: TRM1L, TRMT1L
Organism: Homo sapiens
Interactions: 198
UniProt ID: Q7Z2T5

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0002940 - tRNA N2-guanine methylation
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1158125

MK14
Mitogen-activated protein kinase 14

3

2

High-throughput

0.667

High

532711

CH60
60 kDa heat shock protein, mitochondrial

2

1

High-throughput

0.628

High

1275460

TRM1L
tRNA

1

2

High-throughput

0.618

High

965751

HNRPK
Heterogeneous nuclear ribonucleoprotein K

2

1

High-throughput

0.612

High

372407

MYC
Myc proto-oncogene protein

2

1

High-throughput

0.611

High

1089729

ILF3
Interleukin enhancer-binding factor 3

2

2

High-throughput

0.611

High

1161510

IF16
Gamma-interferon-inducible protein 16

2

1

High-throughput

0.611

High

396406

ESR1
Estrogen receptor

3

0

High-throughput

0.606

High

785253

RL4
Large ribosomal subunit protein uL4

2

0

High-throughput

0.602

High

904875

MECP2
Methyl-CpG-binding protein 2

2

0

High-throughput

0.602

High

969943

RS16
Small ribosomal subunit protein uS9

2

0

High-throughput

0.602

High

1037537

RL18A
Large ribosomal subunit protein eL20

2

0

High-throughput

0.602

High

1199131

PKHO1
Pleckstrin homology domain-containing family O member 1

2

0

High-throughput

0.602

High

1275482

ZSC31
Zinc finger and SCAN domain-containing protein 31

2

0

High-throughput

0.602

High

1275493

ZN692
Zinc finger protein 692

2

0

High-throughput

0.602

High

1275510

H2AW
Core histone macro-H2A.2

2

0

High-throughput

0.602

High

830972

CCNF
Cyclin-F

2

1

High-throughput

0.584

High

985737

RL11
Large ribosomal subunit protein uL5

2

1

High-throughput

0.571

High

129212

MEN1
Menin

2

0

High-throughput

0.559

High

180326

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

1

High-throughput

0.536

High

191689

MAGB2
Melanoma-associated antigen B2

1

2

High-throughput

0.536

High

625464

CSK22
Casein kinase II subunit alpha'

1

2

High-throughput

0.536

High

833134

MNDA
Myeloid cell nuclear differentiation antigen

1

1

High-throughput

0.536

High

848665

MAGA9
Melanoma-associated antigen 9

1

2

High-throughput

0.536

High

849196

KSYK
Tyrosine-protein kinase SYK

1

1

High-throughput

0.536

High

973218

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.536

High

978586

RL23A
Large ribosomal subunit protein uL23

1

1

High-throughput

0.536

High

992823

RACK1
Small ribosomal subunit protein RACK1

1

1

High-throughput

0.536

High

1097149

MK07
Mitogen-activated protein kinase 7

1

3

High-throughput

0.536

High

1099412

SRSF6
Serine/arginine-rich splicing factor 6

1

1

High-throughput

0.536

High

1126972

RBM39
RNA-binding protein 39

1

1

High-throughput

0.536

High

1275480

AURKB
Aurora kinase B

1

3

High-throughput

0.536

High

1275491

RPC7L
DNA-directed RNA polymerase III subunit RPC7-like

1

1

High-throughput

0.536

High

1275492

RBM42
RNA-binding protein 42

1

1

High-throughput

0.536

High

1025118

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.515

High

165054

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

0

High-throughput

0.513

High

303586

SRP72
Signal recognition particle subunit SRP72

1

0

High-throughput

0.513

High

338879

CBX6
Chromobox protein homolog 6

1

0

High-throughput

0.513

High

447158

NPM
Nucleophosmin

1

0

High-throughput

0.513

High

479437

SRP19
Signal recognition particle 19 kDa protein

1

0

High-throughput

0.513

High

621906

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

0

High-throughput

0.513

High

693811

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.513

High

824207

RL13A
Large ribosomal subunit protein uL13

1

0

High-throughput

0.513

High

858966

RL27A
Large ribosomal subunit protein uL15

1

0

High-throughput

0.513

High

859336

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.513

High

859886

RL28
Large ribosomal subunit protein eL28

1

0

High-throughput

0.513

High

912079

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

High-throughput

0.513

High

923510

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

High-throughput

0.513

High

958979

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.513

High

960779

RL15
Large ribosomal subunit protein eL15

1

0

High-throughput

0.513

High

1016074

RL19
Large ribosomal subunit protein eL19

1

0

High-throughput

0.513

High

1027551

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

0

High-throughput

0.513

High

1036661

APBA1
Amyloid-beta A4 precursor protein-binding family A member 1

1

0

High-throughput

0.513

High

1061597

FOXM1
Forkhead box protein M1

1

0

High-throughput

0.513

High

1111415

DGKZ
Diacylglycerol kinase zeta

1

0

High-throughput

0.513

High

1126454

CAPR1
Caprin-1

1

0

High-throughput

0.513

High

1157531

PKN2
Serine/threonine-protein kinase N2

1

0

High-throughput

0.513

High

1275463

ZN467
Zinc finger protein 467

1

0

High-throughput

0.513

High

1275465

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

High-throughput

0.513

High

1275469

EIF1A
Probable RNA-binding protein EIF1AD

1

0

High-throughput

0.513

High

1275474

PSPC1
Paraspeckle component 1

1

0

High-throughput

0.513

High

1275477

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.513

High

1275486

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.513

High

1275503

DDX21
Nucleolar RNA helicase 2

1

0

High-throughput

0.513

High

1275504

ABC3C
DNA dC->dU-editing enzyme APOBEC-3C

1

0

High-throughput

0.513

High

1275507

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.513

High

1275514

SRP68
Signal recognition particle subunit SRP68

1

0

High-throughput

0.513

High

1275517

ABT1
Activator of basal transcription 1

1

0

High-throughput

0.513

High

1275519

G3BP2
Ras GTPase-activating protein-binding protein 2

1

0

High-throughput

0.513

High

1275521

DRG1
Developmentally-regulated GTP-binding protein 1

1

0

High-throughput

0.513

High

1275523

RPC10
DNA-directed RNA polymerase III subunit RPC10

1

0

High-throughput

0.513

High

1275524

RL36
Large ribosomal subunit protein eL36

1

0

High-throughput

0.513

High

964346

SUMO2
Small ubiquitin-related modifier 2

1

1

High-throughput

0.501

High

1275487

M3K14
Mitogen-activated protein kinase kinase kinase 14

1

1

High-throughput

0.489

High

1275494

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.489

High

1275522

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

1

High-throughput

0.489

High

132128

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

1

High-throughput

0.479

High

186375

RPC7
DNA-directed RNA polymerase III subunit RPC7

1

1

Small-scale

0.479

High

239964

SOX15
Transcription factor SOX-15

1

1

High-throughput

0.479

High

242116

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

260120

BRD4
Bromodomain-containing protein 4

1

3

High-throughput

0.479

High

303158

RGS20
Regulator of G-protein signaling 20

1

1

High-throughput

0.479

High

315729

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.479

High

363489

EGFR
Epidermal growth factor receptor

1

1

High-throughput

0.479

High

487467

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.479

High

589018

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

695805

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

777712

VGFR3
Vascular endothelial growth factor receptor 3

1

2

High-throughput

0.479

High

854878

RECQ1
ATP-dependent DNA helicase Q1

1

1

High-throughput

0.479

High

872470

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.479

High

937280

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

3

High-throughput

0.479

High

951997

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

1

1

High-throughput

0.479

High

979027

RS6
Small ribosomal subunit protein eS6

1

2

High-throughput

0.479

High

984835

RL31
Large ribosomal subunit protein eL31

1

1

High-throughput

0.479

High

1008786

RED1
Double-stranded RNA-specific editase 1

1

3

High-throughput

0.479

High

1067463

EP300
Histone acetyltransferase p300

1

2

High-throughput

0.479

High

1113522

CUL3
Cullin-3

1

1

High-throughput

0.479

High

1138346

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

1146716

PCBP1
Poly(rC)-binding protein 1

1

1

High-throughput

0.479

High

1155496

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.479

High

1194180

LARP7
La-related protein 7

1

1

High-throughput

0.479

High

1215683

RC3H1
Roquin-1

1

1

High-throughput

0.479

High

1254398

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

1275464

TAXB1
Tax1-binding protein 1

1

2

High-throughput

0.479

High

1275479

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

1

High-throughput

0.479

High

1275495

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.479

High

1275496

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

1

High-throughput

0.479

High

1275500

RC3H2
Roquin-2

1

1

High-throughput

0.479

High

1275501

BRD7
Bromodomain-containing protein 7

1

3

High-throughput

0.479

High

1275511

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

1

High-throughput

0.479

High

1275518

FZR1
Fizzy-related protein homolog

1

2

High-throughput

0.479

High

1275520

RL26L
Ribosomal protein uL24-like

1

1

High-throughput

0.479

High

1275526

RBM8A
RNA-binding protein 8A

1

1

High-throughput

0.479

High

321581

PRP6
Pre-mRNA-processing factor 6

1

0

High-throughput

0.460

High

157545

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

190973

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.458

High

194245

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.458

High

319869

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

324956

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

385896

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

472849

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

0

High-throughput

0.458

High

504916

H2AB2
Histone H2A-Bbd type 2/3

1

0

High-throughput

0.458

High

558231

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.458

High

643909

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

High-throughput

0.458

High

731419

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.458

High

810183

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.458

High

879224

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

986525

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.458

High

1045442

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

1088889

TP53B
TP53-binding protein 1

1

0

High-throughput

0.458

High

1096070

TADBP
TAR DNA-binding protein 43

1

0

High-throughput

0.458

High

1137366

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.458

High

1234431

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

1246857

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

1271701

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.458

High

1275461

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1275468

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

High-throughput

0.458

High

1275473

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1275475

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

1275476

KAT6A
Histone acetyltransferase KAT6A

1

0

High-throughput

0.458

High

1275481

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

1275488

BARD1
BRCA1-associated RING domain protein 1

1

0

High-throughput

0.458

High

1275489

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

1

0

High-throughput

0.458

High

1275506

NLE1
Notchless protein homolog 1

1

0

High-throughput

0.458

High

1275508

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.458

High

1275513

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

293924

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.437

High

377627

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

1

High-throughput

0.437

High

610013

VGFR1
Vascular endothelial growth factor receptor 1

1

2

High-throughput

0.437

High

768516

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

787040

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

2

High-throughput

0.437

High

942707

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

1

High-throughput

0.437

High

1275466

RHG24
Rho GTPase-activating protein 24

1

1

High-throughput

0.437

High

1275471

NUP43
Nucleoporin Nup43

1

2

High-throughput

0.437

High

1275499

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

1275516

HECD1
E3 ubiquitin-protein ligase HECTD1

1

2

High-throughput

0.437

High

208294

RRP8
Ribosomal RNA-processing protein 8

1

0

High-throughput

0.426

High

401046

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.426

High

430080

JUN
Transcription factor Jun

1

0

High-throughput

0.426

High

1275509

GRHL1
Grainyhead-like protein 1 homolog

1

0

High-throughput

0.426

High

75569

B3KSW4
Regulator of G protein signaling 20

1

1

High-throughput

0.407

High

1218549

Q5VVC8
Large ribosomal subunit protein uL5

1

1

High-throughput

0.407

High

1275484

CEP63
Centrosomal protein of 63 kDa

1

2

High-throughput

0.407

High

935416

FGF8
Fibroblast growth factor 8

2

0

High-throughput

0.328

High

287458

RPC9
DNA-directed RNA polymerase III subunit RPC9

1

0

High-throughput

0.279

Low

430628

RPC4
DNA-directed RNA polymerase III subunit RPC4

1

0

High-throughput

0.279

Low

540042

BCR
Breakpoint cluster region protein

1

0

High-throughput

0.279

Low

657259

KALM
Anosmin-1

1

0

High-throughput

0.279

Low

706187

S10A2
Protein S100-A2

1

0

High-throughput

0.279

Low

718417

CD6
T-cell differentiation antigen CD6

1

0

High-throughput

0.279

Low

1099626

NOGG
Noggin

1

0

High-throughput

0.279

Low

1127415

FGFP1
Fibroblast growth factor-binding protein 1

1

0

High-throughput

0.279

Low

1275462

HEAT3
HEAT repeat-containing protein 3

1

0

High-throughput

0.279

Low

1275478

SGK3
Serine/threonine-protein kinase Sgk3

1

0

High-throughput

0.279

Low

1275483

CC140
Coiled-coil domain-containing protein 140

1

0

High-throughput

0.279

Low

1275490

FEM1A
Protein fem-1 homolog A

1

0

High-throughput

0.279

Low

1275498

RPC6
DNA-directed RNA polymerase III subunit RPC6

1

0

High-throughput

0.279

Low

1275505

RPC5
DNA-directed RNA polymerase III subunit RPC5

1

0

High-throughput

0.279

Low

1275512

CFA97
Cilia- and flagella-associated protein 97

1

0

High-throughput

0.279

Low

1275525

RPC8
DNA-directed RNA polymerase III subunit RPC8

1

0

High-throughput

0.279

Low

422432

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.261

Low

179944

BET1
BET1 homolog

1

0

High-throughput

0.249

Low

272284

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.249

Low

412162

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

560433

IFM1
Interferon-induced transmembrane protein 1

1

0

High-throughput

0.249

Low

576663

GBRA1
Gamma-aminobutyric acid receptor subunit alpha-1

1

0

High-throughput

0.249

Low

901898

RAB9A
Ras-related protein Rab-9A

1

0

High-throughput

0.249

Low

1110637

DCTN2
Dynactin subunit 2

1

0

High-throughput

0.249

Low

1275467

FBXL6
F-box/LRR-repeat protein 6

1

0

High-throughput

0.249

Low

1275470

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.249

Low

1275472

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.249

Low

1275485

NEB2
Neurabin-2

1

0

High-throughput

0.249

Low

1275502

ANLN
Anillin

1

0

High-throughput

0.249

Low

516849

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

1

0

High-throughput

0.232

Low

906302

GPC3
Glypican-3

1

0

High-throughput

0.232

Low

1275497

MAGT1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1

1

0

High-throughput

0.232

Low

1275515

S39AA
Zinc transporter ZIP10

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025