HitPredict

Interactor 1: SH21A (O60880)
SH2 domain-containing protein 1A (Duncan disease SH2-protein) (Signaling lymphocytic activation molecule-associated protein) (SLAM-associated protein) (T-cell signal transduction molecule SAP)
Gene: SH2D1A

Interactor 2: LYN (P07948)
Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
Gene: LYN

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	23503679
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~SH3_1
Common GO terms	GO:0002250 - adaptive immune response GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 128 Hs			1 512
+	Hs
		433530 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		LYN_HUMAN (1-512): 0: 611: 100.00
+	Hs
		442759 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		HCK_HUMAN (1-512): 0: 595: 70.70
+	Mm
		435875 HCK_MOUSE (1-127): 9.56e-42: 145: 19.55		HCK_MOUSE (1-512): 0: 592: 69.92
+	Hs
		411559 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		LCK_HUMAN (1-512): 0: 582: 63.62
+	Hs
		442772 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		SRC_HUMAN (1-510): 0: 580: 51.97
+	Hs
		522840 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		SRC_HUMAN (1-510): 0: 580: 51.97
+	Hs
		337329 ABL1_HUMAN (1-127): 4.39e-40: 143: 26.72		SRC_HUMAN (1-510): 0: 580: 51.97
+	Hs
		412070 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		FYN_HUMAN (1-510): 0: 576: 54.12
+	Hs
		337307 ABL1_HUMAN (1-127): 4.39e-40: 143: 26.72		FYN_HUMAN (1-510): 0: 576: 54.12
+	Hs
		442789 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		ABL2_HUMAN (14-509): 1.38e-171: 517: 36.61
+	Hs
		337315 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		ABL1_HUMAN (32-509): 9.04e-172: 516: 37.88
+	Hs
		789042 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		ABL2_HUMAN (14-509): 1.38e-171: 517: 36.61
+	Hs
		337384 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		ABL1_HUMAN (32-509): 9.04e-172: 516: 37.88
+	Hs
		337293 ABL1_HUMAN (1-127): 4.39e-40: 143: 26.72		ABL1_HUMAN (32-509): 9.04e-172: 516: 37.88
+	Mm
		337615 ABL1_MOUSE (1-127): 5.17e-40: 143: 26.72		ABL1_MOUSE (32-509): 5.71e-172: 516: 37.88
+	Hs
		442813 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		BTK_HUMAN (2-505): 1.48e-156: 462: 33.86
+	Hs
		337440 ABL1_HUMAN (1-127): 4.39e-40: 143: 26.72		BTK_HUMAN (2-505): 1.48e-156: 462: 33.86