Protein: RHG01
Rho GTPase-activating protein 1 (CDC42 GTPase-activating protein) (GTPase-activating protein rhoGAP) (Rho-related small GTPase protein activator) (Rho-type GTPase-activating protein 1) (p50-RhoGAP)

Gene: RHG01, ARHGAP1
Organism: Homo sapiens
Interactions: 193
UniProt ID: Q07960

Gene Ontology (top 5):
GO:0001726 - ruffle
GO:0005096 - GTPase activator activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

955095

CDC42
Cell division control protein 42 homolog

11

20

Small-scale

0.976

High

961987

RHOA
Transforming protein RhoA

9

20

Small-scale

0.972

High

1061234

BNIP2
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2

3

10

Small-scale

0.871

High

466223

RHOC
Rho-related GTP-binding protein RhoC

3

20

High-throughput

0.860

High

988313

RAC1
Ras-related C3 botulinum toxin substrate 1

3

20

Small-scale

0.849

High

1061284

SH3G1
Endophilin-A2

2

20

High-throughput

0.783

High

375453

RASK
GTPase KRas

2

14

High-throughput

0.754

High

630779

RAB4A
Ras-related protein Rab-4A

2

6

High-throughput

0.754

High

976225

RB11A
Ras-related protein Rab-11A

2

4

High-throughput

0.754

High

977958

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.754

High

1015389

RHOG
Rho-related GTP-binding protein RhoG

2

20

Small-scale

0.737

High

1061252

SRGP1
SLIT-ROBO Rho GTPase-activating protein 1

2

14

High-throughput

0.737

High

1061287

FSD1
Fibronectin type III and SPRY domain-containing protein 1

3

18

High-throughput

0.667

High

557256

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

Small-scale

0.647

High

699716

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

15

Small-scale

0.647

High

1061232

RHG01
Rho GTPase-activating protein 1

1

14

Small-scale

0.647

High

1061263

FBX25
F-box only protein 25

3

0

High-throughput

0.638

High

387826

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

2

1

High-throughput

0.628

High

1061249

SETX
Probable helicase senataxin

2

1

High-throughput

0.628

High

1061280

CDK15
Cyclin-dependent kinase 15

2

1

High-throughput

0.628

High

1061251

BNIPL
Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein

1

10

Small-scale

0.621

High

126564

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

341036

DIRA3
GTP-binding protein Di-Ras3

1

5

High-throughput

0.618

High

373901

RASN
GTPase NRas

1

14

High-throughput

0.618

High

581009

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

601252

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

630503

RAB3B
Ras-related protein Rab-3B

1

3

High-throughput

0.618

High

631188

RAB5A
Ras-related protein Rab-5A

1

5

High-throughput

0.618

High

900788

RAB5C
Ras-related protein Rab-5C

1

5

High-throughput

0.618

High

901781

RAB9A
Ras-related protein Rab-9A

1

5

High-throughput

0.618

High

910026

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.618

High

944982

RAB25
Ras-related protein Rab-25

1

4

High-throughput

0.618

High

953409

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

956266

RAB2A
Ras-related protein Rab-2A

1

6

High-throughput

0.618

High

1061238

RAB35
Ras-related protein Rab-35

1

4

High-throughput

0.618

High

1061239

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.618

High

1061297

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

1061299

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

1061245

FOXR2
Forkhead box protein R2

3

2

High-throughput

0.609

High

241495

PRKN
E3 ubiquitin-protein ligase parkin

2

4

High-throughput

0.584

High

363179

EGFR
Epidermal growth factor receptor

2

20

High-throughput

0.584

High

540420

LAMP1
Lysosome-associated membrane glycoprotein 1

2

5

High-throughput

0.584

High

354955

CHK2
Serine/threonine-protein kinase Chk2

1

3

High-throughput

0.541

High

132590

UPK1A
Uroplakin-1a

1

3

High-throughput

0.536

High

602780

AATC
Aspartate aminotransferase, cytoplasmic

1

1

High-throughput

0.536

High

733339

CCR1
C-C chemokine receptor type 1

1

3

High-throughput

0.536

High

872246

SOX2
Transcription factor SOX-2

1

5

High-throughput

0.536

High

1023761

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

1

High-throughput

0.536

High

1061260

FNDC5
Fibronectin type III domain-containing protein 5

1

1

High-throughput

0.536

High

1061289

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

8

High-throughput

0.536

High

1061323

NTNG1
Netrin-G1

1

2

High-throughput

0.536

High

721712

GCH1
GTP cyclohydrolase 1

1

0

High-throughput

0.513

High

788906

TGFR2
TGF-beta receptor type-2

1

0

High-throughput

0.513

High

943040

STX17
Syntaxin-17

1

0

High-throughput

0.513

High

1061276

PRR11
Proline-rich protein 11

1

0

High-throughput

0.513

High

1061290

TX101
Testis-expressed protein 101

1

0

High-throughput

0.513

High

1061302

MBNL1
Muscleblind-like protein 1

1

0

High-throughput

0.513

High

1061324

SSUH2
Protein SSUH2 homolog

1

0

High-throughput

0.513

High

880906

MTR1B
Melatonin receptor type 1B

1

3

High-throughput

0.508

High

185634

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

2

High-throughput

0.501

High

1061317

PHF11
PHD finger protein 11

1

2

High-throughput

0.489

High

1061247

ATRAP
Type-1 angiotensin II receptor-associated protein

1

0

High-throughput

0.486

High

172736

XPO1
Exportin-1

1

12

High-throughput

0.479

High

173907

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

1

High-throughput

0.479

High

189528

STX7
Syntaxin-7

1

3

High-throughput

0.479

High

218098

TGON2
Trans-Golgi network integral membrane protein 2

1

2

High-throughput

0.479

High

226005

STX6
Syntaxin-6

1

1

High-throughput

0.479

High

345711

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

4

High-throughput

0.479

High

390550

TFR1
Transferrin receptor protein 1

1

1

High-throughput

0.479

High

417395

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

2

High-throughput

0.479

High

439713

INSR
Insulin receptor

1

20

High-throughput

0.479

High

465499

IGF1R
Insulin-like growth factor 1 receptor

1

20

High-throughput

0.479

High

537039

HSP7C
Heat shock cognate 71 kDa protein

1

3

High-throughput

0.479

High

541449

FGFR1
Fibroblast growth factor receptor 1

1

16

High-throughput

0.479

High

556037

CADH1
Cadherin-1

1

8

High-throughput

0.479

High

560376

IFM1
Interferon-induced transmembrane protein 1

1

1

High-throughput

0.479

High

562021

LAMP2
Lysosome-associated membrane glycoprotein 2

1

5

High-throughput

0.479

High

603947

CXA1
Gap junction alpha-1 protein

1

3

High-throughput

0.479

High

611093

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

3

High-throughput

0.479

High

642825

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

6

High-throughput

0.479

High

648493

FGFR4
Fibroblast growth factor receptor 4

1

18

High-throughput

0.479

High

692942

DPP4
Dipeptidyl peptidase 4

1

1

High-throughput

0.479

High

698605

CALX
Calnexin

1

1

High-throughput

0.479

High

715557

MARCS
Myristoylated alanine-rich C-kinase substrate

1

1

High-throughput

0.479

High

774313

BASI
Basigin

1

4

High-throughput

0.479

High

791332

SYUA
Alpha-synuclein

1

3

High-throughput

0.479

High

820624

CEAM6
Cell adhesion molecule CEACAM6

1

3

High-throughput

0.479

High

903886

BAP31
B-cell receptor-associated protein 31

1

3

High-throughput

0.479

High

951118

SC61B
Protein transport protein Sec61 subunit beta

1

4

High-throughput

0.479

High

975001

ARF6
ADP-ribosylation factor 6

1

8

High-throughput

0.479

High

986366

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

3

High-throughput

0.479

High

1004041

CXAR
Coxsackievirus and adenovirus receptor

1

4

High-throughput

0.479

High

1031347

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.479

High

1041023

CAV1
Caveolin-1

1

2

High-throughput

0.479

High

1058390

CKAP4
Cytoskeleton-associated protein 4

1

9

High-throughput

0.479

High

1061233

STX4
Syntaxin-4

1

3

High-throughput

0.479

High

1061240

NTRK3
NT-3 growth factor receptor

1

19

High-throughput

0.479

High

1061241

OCLN
Occludin

1

2

High-throughput

0.479

High

1061244

LTOR1
Ragulator complex protein LAMTOR1

1

3

High-throughput

0.479

High

1061248

TRI67
Tripartite motif-containing protein 67

1

17

High-throughput

0.479

High

1061250

ATG9A
Autophagy-related protein 9A

1

3

High-throughput

0.479

High

1061253

TM11B
Transmembrane protease serine 11B

1

5

High-throughput

0.479

High

1061255

TAXB1
Tax1-binding protein 1

1

7

High-throughput

0.479

High

1061258

CXD3
Gap junction delta-3 protein

1

3

High-throughput

0.479

High

1061261

DHB11
Estradiol 17-beta-dehydrogenase 11

1

3

High-throughput

0.479

High

1061264

BICD2
Protein bicaudal D homolog 2

1

12

High-throughput

0.479

High

1061267

AKAP1
A-kinase anchor protein 1, mitochondrial

1

1

High-throughput

0.479

High

1061271

LRC59
Leucine-rich repeat-containing protein 59

1

1

High-throughput

0.479

High

1061278

DNJC1
DnaJ homolog subfamily C member 1

1

2

High-throughput

0.479

High

1061283

DNJC7
DnaJ homolog subfamily C member 7

1

2

High-throughput

0.479

High

1061285

ESYT1
Extended synaptotagmin-1

1

3

High-throughput

0.479

High

1061300

ANLN
Anillin

1

2

High-throughput

0.479

High

1061305

TMPS4
Transmembrane protease serine 4

1

4

High-throughput

0.479

High

1061306

DUS22
Dual specificity protein phosphatase 22

1

1

High-throughput

0.479

High

1061310

ARL15
ADP-ribosylation factor-like protein 15

1

12

High-throughput

0.479

High

1061313

ANFY1
Rabankyrin-5

1

6

High-throughput

0.479

High

1061315

TES
Testin

1

1

High-throughput

0.479

High

1061316

XPO7
Exportin-7

1

10

High-throughput

0.479

High

1061320

ALK
ALK tyrosine kinase receptor

1

19

High-throughput

0.479

High

1061322

LAMP3
Lysosome-associated membrane glycoprotein 3

1

5

High-throughput

0.479

High

210557

DC1L2
Cytoplasmic dynein 1 light intermediate chain 2

1

0

High-throughput

0.458

High

837575

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.458

High

880530

LMAN1
Protein ERGIC-53

1

0

High-throughput

0.458

High

894703

EMD
Emerin

1

0

High-throughput

0.458

High

1061237

STIM1
Stromal interaction molecule 1

1

0

High-throughput

0.458

High

1061242

ACBD5
Acyl-CoA-binding domain-containing protein 5

1

0

High-throughput

0.458

High

1061262

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

1061268

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

0

High-throughput

0.458

High

1061275

TECT2
Tectonic-2

1

0

High-throughput

0.458

High

1061281

PANX1
Pannexin-1

1

0

High-throughput

0.458

High

1061291

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

1061296

DNJC5
DnaJ homolog subfamily C member 5

1

0

High-throughput

0.458

High

1061298

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.458

High

1061303

PXMP2
Peroxisomal membrane protein 2

1

0

High-throughput

0.458

High

1061308

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.458

High

1061312

TM216
Transmembrane protein 216

1

0

High-throughput

0.458

High

1061314

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.458

High

1061318

PPM1H
Protein phosphatase 1H

1

0

High-throughput

0.458

High

1061319

CLC4E
C-type lectin domain family 4 member E

1

0

High-throughput

0.458

High

1061325

FIS1
Mitochondrial fission 1 protein

1

0

High-throughput

0.458

High

58806

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

4

High-throughput

0.445

High

142330

PEX7
Peroxisomal targeting signal 2 receptor

1

4

High-throughput

0.445

High

967686

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

5

High-throughput

0.445

High

1061235

STK4
Serine/threonine-protein kinase 4

1

5

High-throughput

0.445

High

1061243

A16L1
Autophagy-related protein 16-1

1

15

High-throughput

0.445

High

1061266

TGFA1
Transforming growth factor-beta receptor-associated protein 1

1

6

High-throughput

0.445

High

1061294

CAD23
Cadherin-23

1

2

High-throughput

0.445

High

1061307

DDX28
Probable ATP-dependent RNA helicase DDX28

1

5

High-throughput

0.445

High

1061321

GAB2
GRB2-associated-binding protein 2

1

6

High-throughput

0.445

High

1061326

PCDG9
Protocadherin gamma-A9

1

1

High-throughput

0.445

High

105815

APRIO
Alternative prion protein

1

4

High-throughput

0.437

High

327235

ZFPL1
Zinc finger protein-like 1

1

1

High-throughput

0.437

High

418088

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

High-throughput

0.437

High

588541

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.437

High

695292

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.437

High

768033

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

1061254

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

3

High-throughput

0.437

High

1061293

DJC25
DnaJ homolog subfamily C member 25

1

1

High-throughput

0.437

High

1061327

MTCH2
Mitochondrial carrier homolog 2

1

4

High-throughput

0.437

High

125425

LEG9
Galectin-9

1

0

High-throughput

0.426

High

261161

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.426

High

298162

DCTN3
Dynactin subunit 3

1

0

High-throughput

0.426

High

391230

FRIL
Ferritin light chain

1

0

High-throughput

0.426

High

598728

ANFB
Natriuretic peptides B

1

0

High-throughput

0.426

High

1061269

P33MX
Putative monooxygenase p33MONOX

1

0

High-throughput

0.426

High

1061286

CCM2
Cerebral cavernous malformations 2 protein

1

0

High-throughput

0.426

High

1061301

ITM2C
Integral membrane protein 2C

1

0

High-throughput

0.426

High

330138

VENTX
Homeobox protein VENTX

1

5

High-throughput

0.407

High

976800

LCN6
Epididymal-specific lipocalin-6

1

2

High-throughput

0.407

High

1061259

TTC9C
Tetratricopeptide repeat protein 9C

1

2

High-throughput

0.407

High

1061273

KCD12
BTB/POZ domain-containing protein KCTD12

1

6

High-throughput

0.407

High

1061274

SYMM
Methionine--tRNA ligase, mitochondrial

1

2

High-throughput

0.407

High

1061277

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.282

High

1061257

NRSN1
Neurensin-1

1

0

High-throughput

0.279

Low

1061272

SARAF
Store-operated calcium entry-associated regulatory factor

1

0

High-throughput

0.279

Low

1061279

FA81B
Protein FAM81B

1

0

High-throughput

0.279

Low

139854

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

0

High-throughput

0.249

Low

353282

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

847510

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.249

Low

1026984

REEP5
Receptor expression-enhancing protein 5

1

0

High-throughput

0.249

Low

1061256

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

1061265

RHBL4
Rhomboid-related protein 4

1

0

High-throughput

0.249

Low

1061270

S2546
Mitochondrial outer membrane protein SLC25A46

1

0

High-throughput

0.249

Low

1061282

SEC62
Translocation protein SEC62

1

0

High-throughput

0.249

Low

1061288

DERL1
Derlin-1

1

0

High-throughput

0.249

Low

1061292

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

High-throughput

0.249

Low

1061295

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

0

High-throughput

0.249

Low

1061304

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.249

Low

1061309

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.249

Low

1061311

ELOV5
Very long chain fatty acid elongase 5

1

0

High-throughput

0.249

Low

1061236

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.232

Low

1061246

BRID5
BRICHOS domain-containing protein 5

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025