HitPredict

Interactor 1: SH21A (O60880)
SH2 domain-containing protein 1A (Duncan disease SH2-protein) (Signaling lymphocytic activation molecule-associated protein) (SLAM-associated protein) (T-cell signal transduction molecule SAP)
Gene: SH2D1A

Interactor 2: ACK1 (Q07912)
Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2)
Gene: TNK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.845

Property	Details
Experiments	25416956, 25910212
Identification Methods	two hybrid, validated two hybrid, two hybrid prey pooling approach, two hybrid array, two hybrid bait and prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 128 Hs			1 1038
+	Hs
		442817 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		ACK1_HUMAN (1-1038): 0: 805: 100.00
+	Hs
		337315 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		ABL1_HUMAN (1-955): 4.84e-144: 462: 19.03
+	Hs
		337384 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		ABL1_HUMAN (1-955): 4.84e-144: 462: 19.03
+	Hs
		442812 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		FAK1_HUMAN (6-692): 3.3e-131: 425: 21.01
+	Hs
		442833 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		ERBB4_HUMAN (84-754): 3.34e-128: 423: 24.17
+	Hs
		789067 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		ERBB4_HUMAN (84-754): 3.34e-128: 423: 24.17
+	Hs
		442789 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		ABL2_HUMAN (1-845): 1.9e-126: 415: 19.68
+	Hs
		789042 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		ABL2_HUMAN (1-845): 1.9e-126: 415: 19.68
+	Hs
		665558 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		EPHB2_HUMAN (10-539): 5.4e-127: 414: 21.60
+	Hs
		789049 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		EPHA4_HUMAN (84-486): 5.91e-125: 407: 23.98
+	Hs
		442772 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		SRC_HUMAN (1-400): 3.99e-127: 399: 31.42
+	Hs
		522840 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		SRC_HUMAN (1-400): 3.99e-127: 399: 31.42
+	Hs
		412070 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		FYN_HUMAN (1-400): 2.52e-126: 397: 30.18
+	Hs
		411559 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		LCK_HUMAN (1-398): 8.72e-125: 391: 30.08
+	Hs
		789068 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		EPHA7_HUMAN (109-395): 5.69e-109: 364: 32.77
+	Hs
		433530 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		LYN_HUMAN (92-388): 4.52e-112: 358: 36.79
+	Hs
		442759 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		HCK_HUMAN (76-388): 8.7e-112: 358: 34.40
+	Hs
		337804 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		EGFR_HUMAN (105-387): 2.98e-55: 211: 39.58
+	Hs
		338083 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		EGFR_HUMAN (105-387): 2.98e-55: 211: 39.58