Protein: THOC2
THO complex subunit 2 (Tho2) (hTREX120)

Gene: THOC2
Organism: Homo sapiens
Interactions: 221
UniProt ID: Q8NI27

Gene Ontology (top 5):
GO:0000346 - transcription export complex
GO:0000347 - THO complex
GO:0000445 - THO complex part of transcription export complex
GO:0000902 - cell morphogenesis
GO:0001824 - blastocyst development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1340995

THOC1
THO complex subunit 1

11

3

Small-scale

0.975

High

1118101

DX39B
Spliceosome RNA helicase DDX39B

8

15

Small-scale

0.970

High

1292042

THOC6
THO complex subunit 6

4

20

Small-scale

0.881

High

1233200

THOC7
THO complex subunit 7

4

0

Small-scale

0.840

High

1340997

THOC3
THO complex subunit 3

7

18

Small-scale

0.746

High

1117195

THOC5
THO complex subunit 5

9

2

Small-scale

0.745

High

1290083

THOC4
THO complex subunit 4

6

8

Small-scale

0.735

High

123147

DX39A
ATP-dependent RNA helicase DDX39A

1

14

High-throughput

0.691

High

807505

IF4A3
Eukaryotic initiation factor 4A-III

1

11

High-throughput

0.691

High

1062557

DHX9
ATP-dependent RNA helicase A

1

4

High-throughput

0.691

High

1340998

WDR90
WD repeat-containing protein 90

1

12

High-throughput

0.691

High

1198605

NCBP3
Nuclear cap-binding protein subunit 3

4

2

High-throughput

0.678

High

461730

HS90A
Heat shock protein HSP 90-alpha

3

9

High-throughput

0.640

High

468617

HS90B
Heat shock protein HSP 90-beta

3

9

High-throughput

0.640

High

914675

RM12
Large ribosomal subunit protein bL12m

3

0

High-throughput

0.634

High

1066718

NCBP1
Nuclear cap-binding protein subunit 1

3

3

Small-scale

0.633

High

285375

EED
Polycomb protein EED

1

20

High-throughput

0.618

High

903423

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

20

High-throughput

0.618

High

1341013

DDX23
Probable ATP-dependent RNA helicase DDX23

1

10

High-throughput

0.618

High

352497

TOP3B
DNA topoisomerase 3-beta-1

2

1

High-throughput

0.611

High

447240

NPM
Nucleophosmin

2

4

High-throughput

0.601

High

242344

PRKN
E3 ubiquitin-protein ligase parkin

2

13

High-throughput

0.584

High

346092

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

15

High-throughput

0.584

High

372634

MYC
Myc proto-oncogene protein

2

20

High-throughput

0.584

High

589214

RFA2
Replication protein A 32 kDa subunit

2

12

High-throughput

0.584

High

613406

VINC
Vinculin

2

6

High-throughput

0.584

High

695997

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

11

High-throughput

0.584

High

768695

RFA3
Replication protein A 14 kDa subunit

2

12

High-throughput

0.584

High

1290603

ZCH18
Zinc finger CCCH domain-containing protein 18

2

20

High-throughput

0.584

High

1341053

CHTOP
Chromatin target of PRMT1 protein

2

0

Small-scale

0.576

High

1341045

DDX41
Probable ATP-dependent RNA helicase DDX41

1

4

High-throughput

0.575

High

230550

KIF1C
Kinesin-like protein KIF1C

1

12

High-throughput

0.536

High

246061

KIF1B
Kinesin-like protein KIF1B

1

12

High-throughput

0.536

High

272971

ZC11A
Zinc finger CCCH domain-containing protein 11A

1

1

High-throughput

0.536

High

634542

LMNB1
Lamin-B1

1

7

High-throughput

0.536

High

900047

FXR1
RNA-binding protein FXR1

1

10

High-throughput

0.536

High

928495

TERF1
Telomeric repeat-binding factor 1

1

4

High-throughput

0.536

High

937299

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

15

High-throughput

0.536

High

1013162

SARNP
SAP domain-containing ribonucleoprotein

1

2

High-throughput

0.536

High

1038333

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

12

High-throughput

0.536

High

1100692

STX3
Syntaxin-3

1

3

High-throughput

0.536

High

1110383

KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

1

2

High-throughput

0.536

High

1112441

MTMR3
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3

1

9

High-throughput

0.536

High

1115838

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

12

High-throughput

0.536

High

1134293

IMB1
Importin subunit beta-1

1

2

High-throughput

0.536

High

1215557

RNH2B
Ribonuclease H2 subunit B

1

1

High-throughput

0.536

High

1219306

ECM29
Proteasome adapter and scaffold protein ECM29

1

3

High-throughput

0.536

High

1229575

VIR
Protein virilizer homolog

1

4

High-throughput

0.536

High

1331930

CS047
Uncharacterized protein C19orf47

1

1

High-throughput

0.536

High

1341006

CTIP
DNA endonuclease RBBP8

1

1

High-throughput

0.536

High

1341011

CAB45
45 kDa calcium-binding protein

1

4

High-throughput

0.536

High

1341018

PDIP3
Polymerase delta-interacting protein 3

1

6

High-throughput

0.536

High

1341024

MOB1A
MOB kinase activator 1A

1

3

High-throughput

0.536

High

1341026

MED20
Mediator of RNA polymerase II transcription subunit 20

1

2

High-throughput

0.536

High

1341030

MED4
Mediator of RNA polymerase II transcription subunit 4

1

2

High-throughput

0.536

High

1341036

BCLF1
Bcl-2-associated transcription factor 1

1

15

High-throughput

0.536

High

1341046

ZN346
Zinc finger protein 346

1

1

High-throughput

0.536

High

1341048

KMT2B
Histone-lysine N-methyltransferase 2B

1

20

High-throughput

0.536

High

1150550

TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein

1

0

High-throughput

0.513

High

1340988

RT27
Small ribosomal subunit protein mS27

1

0

High-throughput

0.513

High

1341002

UIF
UAP56-interacting factor

1

0

High-throughput

0.513

High

1341007

ATP5S
ATP synthase subunit s, mitochondrial

1

0

High-throughput

0.513

High

1341012

RAMAC
RNA guanine-N7 methyltransferase activating subunit

1

0

High-throughput

0.513

High

1341037

CRIPT
Cysteine-rich PDZ-binding protein

1

0

High-throughput

0.513

High

951769

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

7

High-throughput

0.501

High

1340991

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

14

High-throughput

0.501

High

897546

BPL1
Biotin--protein ligase

1

0

High-throughput

0.493

High

1233237

NADE
Glutamine-dependent NAD(+) synthetase

1

0

High-throughput

0.493

High

344419

TBCD8
TBC1 domain family member 8

1

6

High-throughput

0.489

High

619862

VCAM1
Vascular cell adhesion protein 1

1

7

High-throughput

0.489

High

853117

ACDSB
Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial

1

2

High-throughput

0.489

High

870448

SC6A9
Sodium- and chloride-dependent glycine transporter 1

1

4

High-throughput

0.489

High

1142105

P2RY6
P2Y purinoceptor 6

1

3

High-throughput

0.489

High

1312857

GPAM1
GPALPP motifs-containing protein 1

1

1

High-throughput

0.489

High

1340986

TM131
Transmembrane protein 131

1

10

High-throughput

0.489

High

1341008

AKAP9
A-kinase anchor protein 9

1

20

High-throughput

0.489

High

1341025

PKHF2
Pleckstrin homology domain-containing family F member 2

1

15

High-throughput

0.489

High

129269

MEN1
Menin

1

9

High-throughput

0.479

High

134806

SAP18
Histone deacetylase complex subunit SAP18

1

3

High-throughput

0.479

High

157639

CTRO
Citron Rho-interacting kinase

1

20

High-throughput

0.479

High

164159

KIF3C
Kinesin-like protein KIF3C

1

8

High-throughput

0.479

High

177024

CE290
Centrosomal protein of 290 kDa

1

19

High-throughput

0.479

High

248009

NUPR1
Nuclear protein 1

1

5

High-throughput

0.479

High

260196

BRD4
Bromodomain-containing protein 4

1

20

High-throughput

0.479

High

272332

OBSL1
Obscurin-like protein 1

1

8

High-throughput

0.479

High

294057

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.479

High

319925

UFL1
E3 UFM1-protein ligase 1

1

4

High-throughput

0.479

High

331165

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.479

High

401172

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

16

High-throughput

0.479

High

406412

MYCN
N-myc proto-oncogene protein

1

20

High-throughput

0.479

High

412286

NTRK1
High affinity nerve growth factor receptor

1

8

High-throughput

0.479

High

414255

P53
Cellular tumor antigen p53

1

7

High-throughput

0.479

High

459317

CATL1
Procathepsin L

1

3

High-throughput

0.479

High

472907

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

14

High-throughput

0.479

High

474140

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

558280

XRCC6
X-ray repair cross-complementing protein 6

1

8

High-throughput

0.479

High

600526

ZNF43
Zinc finger protein 43

1

2

High-throughput

0.479

High

650863

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

9

High-throughput

0.479

High

697186

APEX1
DNA repair nuclease/redox regulator APEX1

1

6

High-throughput

0.479

High

714284

PML
Protein PML

1

15

High-throughput

0.479

High

731480

STIP1
Stress-induced-phosphoprotein 1

1

3

High-throughput

0.479

High

775214

FUS
RNA-binding protein FUS

1

7

High-throughput

0.479

High

821463

TCPZ
T-complex protein 1 subunit zeta

1

1

High-throughput

0.479

High

831094

CCNF
Cyclin-F

1

8

High-throughput

0.479

High

855692

CRK
Adapter molecule crk

1

15

High-throughput

0.479

High

862312

YAP1
Transcriptional coactivator YAP1

1

19

High-throughput

0.479

High

879284

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

18

High-throughput

0.479

High

889157

RBM25
RNA-binding protein 25

1

17

High-throughput

0.479

High

904948

MECP2
Methyl-CpG-binding protein 2

1

18

High-throughput

0.479

High

970808

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

8

High-throughput

0.479

High

980020

H4
Histone H4

1

13

High-throughput

0.479

High

985252

RL10A
Large ribosomal subunit protein uL1

1

1

High-throughput

0.479

High

989761

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

1

5

High-throughput

0.479

High

992505

RS21
Small ribosomal subunit protein eS21

1

1

High-throughput

0.479

High

1004861

RNF4
E3 ubiquitin-protein ligase RNF4

1

3

High-throughput

0.479

High

1008807

RED1
Double-stranded RNA-specific editase 1

1

14

High-throughput

0.479

High

1024712

VIGLN
Vigilin

1

11

High-throughput

0.479

High

1029341

SET
Protein SET

1

3

High-throughput

0.479

High

1035795

KIF23
Kinesin-like protein KIF23

1

18

High-throughput

0.479

High

1040855

MECOM
Histone-lysine N-methyltransferase MECOM

1

6

High-throughput

0.479

High

1088921

TP53B
TP53-binding protein 1

1

9

High-throughput

0.479

High

1096357

ROA0
Heterogeneous nuclear ribonucleoprotein A0

1

12

High-throughput

0.479

High

1107037

BIRC3
Baculoviral IAP repeat-containing protein 3

1

7

High-throughput

0.479

High

1113761

CUL3
Cullin-3

1

20

High-throughput

0.479

High

1130791

RRP5
Protein RRP5 homolog

1

4

High-throughput

0.479

High

1134998

CUL7
Cullin-7

1

4

High-throughput

0.479

High

1137405

SUZ12
Polycomb protein SUZ12

1

4

High-throughput

0.479

High

1137870

TNIP1
TNFAIP3-interacting protein 1

1

19

High-throughput

0.479

High

1141227

BRD3
Bromodomain-containing protein 3

1

20

High-throughput

0.479

High

1245393

ZC3HE
Zinc finger CCCH domain-containing protein 14

1

3

High-throughput

0.479

High

1254736

TRI67
Tripartite motif-containing protein 67

1

18

High-throughput

0.479

High

1276511

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

9

High-throughput

0.479

High

1287954

PB1
Protein polybromo-1

1

14

High-throughput

0.479

High

1289469

NAA40
N-alpha-acetyltransferase 40

1

8

High-throughput

0.479

High

1313279

SMC5
Structural maintenance of chromosomes protein 5

1

20

High-throughput

0.479

High

1338692

BD1L1
Biorientation of chromosomes in cell division protein 1-like 1

1

17

High-throughput

0.479

High

1340982

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

7

High-throughput

0.479

High

1340985

KBTB7
Kelch repeat and BTB domain-containing protein 7

1

6

High-throughput

0.479

High

1340987

TOPB1
DNA topoisomerase 2-binding protein 1

1

12

High-throughput

0.479

High

1340989

RBP56
TATA-binding protein-associated factor 2N

1

5

High-throughput

0.479

High

1340993

FUBP1
Far upstream element-binding protein 1

1

12

High-throughput

0.479

High

1340994

DCPS
m7GpppX diphosphatase

1

2

High-throughput

0.479

High

1340996

DDRGK
DDRGK domain-containing protein 1

1

3

High-throughput

0.479

High

1341003

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

1341004

RING2
E3 ubiquitin-protein ligase RING2

1

15

High-throughput

0.479

High

1341005

PMYT1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

1

13

High-throughput

0.479

High

1341015

RNF17
RING finger protein 17

1

3

High-throughput

0.479

High

1341016

FACD2
Fanconi anemia group D2 protein

1

11

High-throughput

0.479

High

1341019

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

4

High-throughput

0.479

High

1341020

KI13A
Kinesin-like protein KIF13A

1

10

High-throughput

0.479

High

1341021

MYLK2
Myosin light chain kinase 2, skeletal/cardiac muscle

1

11

High-throughput

0.479

High

1341022

UN45A
Protein unc-45 homolog A

1

16

High-throughput

0.479

High

1341023

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.479

High

1341028

PRD16
Histone-lysine N-methyltransferase PRDM16

1

6

High-throughput

0.479

High

1341029

BRD7
Bromodomain-containing protein 7

1

17

High-throughput

0.479

High

1341031

ANLN
Anillin

1

12

High-throughput

0.479

High

1341032

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

13

High-throughput

0.479

High

1341034

AATF
Protein AATF

1

3

High-throughput

0.479

High

1341035

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

6

High-throughput

0.479

High

1341041

STK26
Serine/threonine-protein kinase 26

1

11

High-throughput

0.479

High

1341043

ZRAN1
Ubiquitin thioesterase ZRANB1

1

18

High-throughput

0.479

High

1341049

PPIE
Peptidyl-prolyl cis-trans isomerase E

1

4

High-throughput

0.479

High

1341050

ASF1A
Histone chaperone ASF1A

1

3

High-throughput

0.479

High

1341051

ZBTB1
Zinc finger and BTB domain-containing protein 1

1

4

High-throughput

0.479

High

1341054

YTHD2
YTH domain-containing family protein 2

1

8

High-throughput

0.479

High

709143

TPP2
Tripeptidyl-peptidase 2

1

0

High-throughput

0.458

High

938067

TPD52
Tumor protein D52

1

0

High-throughput

0.458

High

1193448

CCD14
Coiled-coil domain-containing protein 14

1

0

High-throughput

0.458

High

1332870

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.458

High

1340999

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

1341009

CND3
Condensin complex subunit 3

1

0

High-throughput

0.458

High

1341027

CNO10
CCR4-NOT transcription complex subunit 10

1

0

High-throughput

0.458

High

1341033

BEX4
Protein BEX4

1

0

High-throughput

0.458

High

1341040

LUZP4
Leucine zipper protein 4

1

0

Small-scale

0.458

High

1341044

LCAP
Leucyl-cystinyl aminopeptidase

1

0

High-throughput

0.458

High

1341001

CEP63
Centrosomal protein of 63 kDa

1

17

High-throughput

0.457

High

96820

E9PB61
Aly/REF export factor

1

9

High-throughput

0.445

High

344254

PTBP3
Polypyrimidine tract-binding protein 3

1

1

High-throughput

0.445

High

430152

JUN
Transcription factor Jun

1

11

High-throughput

0.445

High

618154

K2C4
Keratin, type II cytoskeletal 4

1

2

High-throughput

0.445

High

1111123

SNW1
SNW domain-containing protein 1

1

3

High-throughput

0.445

High

1119215

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

11

High-throughput

0.445

High

1130351

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

10

High-throughput

0.445

High

1150767

SF01
Splicing factor 1

1

7

High-throughput

0.445

High

1203198

ODFP2
Outer dense fiber protein 2

1

14

High-throughput

0.445

High

1207501

GNAS1
Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas

1

5

High-throughput

0.445

High

1209416

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

11

High-throughput

0.445

High

1287807

PABP2
Polyadenylate-binding protein 2

1

8

High-throughput

0.445

High

1341038

KCMF1
E3 ubiquitin-protein ligase KCMF1

1

1

High-throughput

0.445

High

1341042

NXF1
Nuclear RNA export factor 1

1

2

Small-scale

0.445

High

158531

NCAN
Neurocan core protein

1

11

High-throughput

0.437

High

654991

ITA6
Integrin alpha-6

1

4

High-throughput

0.437

High

1124864

FLOT2
Flotillin-2

1

5

High-throughput

0.437

High

1141803

EEA1
Early endosome antigen 1

1

17

High-throughput

0.437

High

1257022

SYDE1
Rho GTPase-activating protein SYDE1

1

5

High-throughput

0.437

High

1340981

SH3R3
E3 ubiquitin-protein ligase SH3RF3

1

13

High-throughput

0.437

High

1340983

COG1
Conserved oligomeric Golgi complex subunit 1

1

1

High-throughput

0.437

High

1340990

B2CL2
Bcl-2-like protein 2

1

1

High-throughput

0.437

High

1341014

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

6

High-throughput

0.437

High

1341039

RM27
Large ribosomal subunit protein bL27m

1

1

High-throughput

0.437

High

1341047

HECD1
E3 ubiquitin-protein ligase HECTD1

1

14

High-throughput

0.437

High

887042

CEBPA
CCAAT/enhancer-binding protein alpha

1

11

High-throughput

0.408

High

62565

S35F4
Solute carrier family 35 member F4

1

3

High-throughput

0.407

High

65848

A6NHV6
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

1

17

High-throughput

0.407

High

87510

OSCRI
SCRIB overlapping open reading frame protein

1

3

High-throughput

0.407

High

94389

D6RAN8
Large ribosomal subunit protein bL27m

1

1

High-throughput

0.407

High

96831

E9PBL8
Conserved oligomeric Golgi complex subunit 1

1

1

High-throughput

0.407

High

213203

CP110
Centriolar coiled-coil protein of 110 kDa

1

2

High-throughput

0.407

High

1340984

Q8WVC2
40S ribosomal protein S21

1

1

High-throughput

0.407

High

1341017

S46A2
Solute carrier family 46 member 2

1

3

High-throughput

0.407

High

298754

ATP5H
ATP synthase peripheral stalk subunit d, mitochondrial

2

0

High-throughput

0.305

High

184482

SURF4
Surfeit locus protein 4

1

0

High-throughput

0.279

Low

420026

B3A2
Anion exchange protein 2

1

0

High-throughput

0.279

Low

961553

VA0D1
V-type proton ATPase subunit d 1

1

0

High-throughput

0.279

Low

1188005

GNPTA
N-acetylglucosamine-1-phosphotransferase subunits alpha/beta

1

0

High-throughput

0.279

Low

1214618

EEIG2
EEIG family member 2

1

0

High-throughput

0.279

Low

1341052

CCDC9
Coiled-coil domain-containing protein 9

1

0

High-throughput

0.279

Low

1180652

AP5B1
AP-5 complex subunit beta-1

1

0

High-throughput

0.249

Low

1340992

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.249

Low

1341000

TBATA
Protein TBATA

1

0

High-throughput

0.249

Low

1341010

CMS1
Protein CMSS1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025