HitPredict

Interactor 1: SH21A (O60880)
SH2 domain-containing protein 1A (Duncan disease SH2-protein) (Signaling lymphocytic activation molecule-associated protein) (SLAM-associated protein) (T-cell signal transduction molecule SAP)
Gene: SH2D1A

Interactor 2: LRRF2 (Q9Y608)
Leucine-rich repeat flightless-interacting protein 2 (LRR FLII-interacting protein 2)
Gene: LRRFIP2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.50	0.489

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 128 Hs			1 721
+	Hs
		411797 LCK_HUMAN (1-125): 4.76e-41: 143: 19.08		GOGA5_HUMAN (141-721): 3.86e-32: 135: 13.97
+	Hs
		411758 LCK_HUMAN (1-125): 4.76e-41: 143: 19.08		MRCKA_HUMAN (231-721): 3.54e-31: 133: 11.66
+	Hs
		433818 LYN_HUMAN (1-125): 1.04e-39: 140: 19.85		MRCKA_HUMAN (231-721): 3.54e-31: 133: 11.66
+	Hs
		411908 LCK_HUMAN (1-125): 4.76e-41: 143: 19.08		MRCKB_HUMAN (402-721): 6.25e-17: 87.6: 15.27
+	Hs
		433781 LYN_HUMAN (1-125): 1.04e-39: 140: 19.85		ITSN1_HUMAN (382-721): 3.96e-17: 88.4: 15.71
+	Hs
		434101 LYN_HUMAN (1-125): 1.04e-39: 140: 19.85		MRCKB_HUMAN (402-721): 6.25e-17: 87.6: 15.27
+	Hs
		411800 LCK_HUMAN (1-125): 4.76e-41: 143: 19.08		DLG5_HUMAN (219-569): 1.09e-12: 74.1: 10.72
+	Hs
		176448 SHIP2_HUMAN (3-122): 1.12e-34: 128: 37.50		ITSN1_HUMAN (382-721): 3.96e-17: 88.4: 15.71
+	Hs
		433909 LYN_HUMAN (1-125): 1.04e-39: 140: 19.85		DLG5_HUMAN (219-569): 1.09e-12: 74.1: 10.72
+	Mm
		1159873 SHIP2_MOUSE (3-123): 2.34e-35: 130: 38.84		ITSN1_MOUSE (249-571): 5.15e-14: 78.4: 13.17
+	Hs
		523231 SRC_HUMAN (1-127): 8.71e-39: 138: 20.90		MYH4_HUMAN (219-656): 1.68e-11: 70.3: 11.38
+	Hs
		412287 FYN_HUMAN (1-125): 4.91e-37: 133: 18.52		MY18A_HUMAN (332-715): 3.36e-12: 72.4: 11.16
+	Hs
		111443 J3QRU1_HUMAN (1-127): 2.83e-40: 142: 19.40		MYH9_HUMAN (417-721): 2.86e-09: 62.9: 13.12
+	Hs
		433272 YES_HUMAN (1-127): 2.68e-40: 142: 19.40		MYH9_HUMAN (417-721): 2.86e-09: 62.9: 13.12
+	Hs
		433620 LYN_HUMAN (1-125): 1.04e-39: 140: 19.85		MYH9_HUMAN (417-721): 2.86e-09: 62.9: 13.12
+	Hs
		728465 GRB2_HUMAN (1-123): 1.97e-35: 122: 19.69		MYH11_HUMAN (421-721): 1.67e-13: 76.8: 16.56
+	Hs
		724720 BLK_HUMAN (1-125): 7.14e-38: 135: 18.46		MYH9_HUMAN (417-721): 2.86e-09: 62.9: 13.12
+	Hs
		412058 FYN_HUMAN (1-125): 4.91e-37: 133: 18.52		MYH9_HUMAN (417-721): 2.86e-09: 62.9: 13.12
+	Hs
		725134 GRB2_HUMAN (1-123): 1.97e-35: 122: 19.69		MYH10_HUMAN (466-719): 8.82e-11: 67.9: 16.93
+	Hs
		724756 GRB2_HUMAN (1-123): 1.97e-35: 122: 19.69		MYH9_HUMAN (417-721): 2.86e-09: 62.9: 13.12