HitPredict

Interactor 1: BRD4 (O60885)
Bromodomain-containing protein 4 (Protein HUNK1)
Gene: BRD4

Interactor 2: TOP1 (P11387)
DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)
Gene: TOP1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	31239290, 32416067, 30554943
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005694 - chromosome GO:0006338 - chromatin remodeling
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1362 Hs			1 765
+	Hs
		508346 BRD2_HUMAN (3-737): 2.87e-55: 209: 46.43		TOP1_HUMAN (1-765): 0: 932: 100.00
+	Hs
		508537 BRD3_HUMAN (37-738): 5.99e-55: 207: 47.53		TOP1_HUMAN (1-765): 0: 932: 100.00
+	Hs
		508596 PB1_HUMAN (26-956): 2.35e-19: 97.1: 10.81		TOP1_HUMAN (1-765): 0: 932: 100.00
+	Rn
		1149818 Q6AYL3_RAT (336-590): 5.88e-18: 88.6: 22.75		TOP1_RAT (1-765): 0: 922: 96.48
+	Hs
		244681 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		THOC2_HUMAN (7-198): 3.62e-09: 62.4: 16.42
+	Hs
		244571 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		NIPBL_HUMAN (5-216): 7.71e-09: 61.7: 10.92
+	Hs
		1067060 BRD3_HUMAN (37-738): 5.99e-55: 207: 47.53		THOC2_HUMAN (7-198): 3.62e-09: 62.4: 16.42
+	Hs
		1067006 BRD3_HUMAN (37-738): 5.99e-55: 207: 47.53		NIPBL_HUMAN (5-216): 7.71e-09: 61.7: 10.92