Protein: FOXK2
Forkhead box protein K2 (G/T-mismatch specific binding protein) (nGTBP) (Interleukin enhancer-binding factor 1)

Gene: FOXK2
Organism: Homo sapiens
Interactions: 239
UniProt ID: Q01167

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1029718

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

12

5

Small-scale

0.761

High

159609

DVL2
Segment polarity protein dishevelled homolog DVL-2

6

3

Small-scale

0.729

High

1029709

ASXL1
Polycomb group protein ASXL1

5

6

Small-scale

0.721

High

1029686

RBBP7
Histone-binding protein RBBP7

5

7

Small-scale

0.714

High

1029703

ASXL2
Putative Polycomb group protein ASXL2

5

16

Small-scale

0.714

High

571589

IRF2
Interferon regulatory factor 2

4

5

High-throughput

0.711

High

282236

SAP30
Histone deacetylase complex subunit SAP30

4

2

Small-scale

0.704

High

279343

TULP3
Tubby-related protein 3

4

1

High-throughput

0.697

High

1029660

TFAP4
Transcription factor AP-4

4

3

High-throughput

0.697

High

133105

FOXE1
Forkhead box protein E1

1

19

High-throughput

0.691

High

285882

SF3B1
Splicing factor 3B subunit 1

1

12

High-throughput

0.691

High

354952

CHK2
Serine/threonine-protein kinase Chk2

1

11

High-throughput

0.691

High

625318

CSK22
Casein kinase II subunit alpha'

1

7

High-throughput

0.691

High

1006342

SRPK2
SRSF protein kinase 2

1

6

High-throughput

0.691

High

1017401

FOXK1
Forkhead box protein K1

1

18

High-throughput

0.691

High

1029726

MCRS1
Microspherule protein 1

1

1

High-throughput

0.691

High

1029773

E2AK3
Eukaryotic translation initiation factor 2-alpha kinase 3

1

17

High-throughput

0.691

High

1029676

HDAC1
Histone deacetylase 1

4

14

Small-scale

0.691

High

1029735

SIN3A
Paired amphipathic helix protein Sin3a

3

7

Small-scale

0.690

High

905381

HCFC1
Host cell factor 1

3

7

Small-scale

0.674

High

1029670

GPS2
G protein pathway suppressor 2

3

2

High-throughput

0.667

High

395931

ESR1
Estrogen receptor

3

20

Small-scale

0.665

High

484106

PGFRB
Platelet-derived growth factor receptor beta

3

5

High-throughput

0.662

High

1029674

IKZF1
DNA-binding protein Ikaros

3

3

High-throughput

0.662

High

1029765

SHCAF
SIN3-HDAC complex-associated factor

3

1

High-throughput

0.662

High

261396

TBL1X
F-box-like/WD repeat-containing protein TBL1X

2

11

Small-scale

0.649

High

1029705

KANL1
KAT8 regulatory NSL complex subunit 1

3

0

High-throughput

0.646

High

259810

BRD4
Bromodomain-containing protein 4

3

9

High-throughput

0.640

High

176295

ZBT39
Zinc finger and BTB domain-containing protein 39

2

1

High-throughput

0.628

High

278307

NCOR1
Nuclear receptor corepressor 1

2

20

Small-scale

0.628

High

622588

TNR1A
Tumor necrosis factor receptor superfamily member 1A

2

2

High-throughput

0.628

High

711760

ARI4A
AT-rich interactive domain-containing protein 4A

2

20

High-throughput

0.628

High

1029719

HDAC2
Histone deacetylase 2

2

14

Small-scale

0.628

High

1029721

DVL3
Segment polarity protein dishevelled homolog DVL-3

2

3

High-throughput

0.628

High

1029751

SP130
Histone deacetylase complex subunit SAP130

2

13

Small-scale

0.628

High

1029752

ING2
Inhibitor of growth protein 2

2

10

High-throughput

0.628

High

1029755

P63
Tumor protein 63

2

11

High-throughput

0.628

High

1029781

ING1
Inhibitor of growth protein 1

2

12

High-throughput

0.628

High

1029797

NCOR2
Nuclear receptor corepressor 2

2

15

Small-scale

0.628

High

1029745

TBL1R
F-box-like/WD repeat-containing protein TBL1XR1

2

11

Small-scale

0.619

High

340868

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

1

16

High-throughput

0.618

High

400669

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.618

High

738967

ELF1
ETS-related transcription factor Elf-1

1

14

High-throughput

0.618

High

1029663

TF65
Transcription factor p65

1

12

High-throughput

0.618

High

1029788

CD11A
Cyclin-dependent kinase 11A

1

6

High-throughput

0.618

High

872208

SOX2
Transcription factor SOX-2

2

20

High-throughput

0.611

High

1029733

CIC
Protein capicua homolog

2

20

High-throughput

0.611

High

1029723

ZN428
Zinc finger protein 428

3

1

High-throughput

0.604

High

1029774

KANL3
KAT8 regulatory NSL complex subunit 3

2

0

High-throughput

0.602

High

1029682

RNPS1
RNA-binding protein with serine-rich domain 1

2

3

High-throughput

0.601

High

1029742

MTA3
Metastasis-associated protein MTA3

1

17

Small-scale

0.586

High

1029782

RCOR1
REST corepressor 1

1

17

Small-scale

0.586

High

371790

MYC
Myc proto-oncogene protein

2

10

High-throughput

0.584

High

1029681

NFIX
Nuclear factor 1 X-type

2

20

High-throughput

0.584

High

1029659

FOXK2
Forkhead box protein K2

1

18

High-throughput

0.575

High

1029728

SAHH3
Adenosylhomocysteinase 3

2

9

High-throughput

0.574

High

959565

MAX
Protein max

1

9

High-throughput

0.554

High

211914

SPIT1
Kunitz-type protease inhibitor 1

2

2

High-throughput

0.549

High

74467

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

16

High-throughput

0.536

High

158430

RFXK
DNA-binding protein RFXANK

1

7

High-throughput

0.536

High

163633

GNB5
Guanine nucleotide-binding protein subunit beta-5

1

5

High-throughput

0.536

High

177202

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

1

6

High-throughput

0.536

High

187063

PPM1G
Protein phosphatase 1G

1

1

High-throughput

0.536

High

188241

HDAC3
Histone deacetylase 3

1

12

Small-scale

0.536

High

193773

PER1
Period circadian protein homolog 1

1

6

High-throughput

0.536

High

243603

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

20

High-throughput

0.536

High

274309

SIN3B
Paired amphipathic helix protein Sin3b

1

7

High-throughput

0.536

High

277649

H2AY
Core histone macro-H2A.1

1

8

High-throughput

0.536

High

283072

PSIP1
PC4 and SFRS1-interacting protein

1

6

High-throughput

0.536

High

289505

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

9

High-throughput

0.536

High

316813

MTA2
Metastasis-associated protein MTA2

1

10

Small-scale

0.536

High

413642

P53
Cellular tumor antigen p53

1

11

High-throughput

0.536

High

442676

RB
Retinoblastoma-associated protein

1

8

High-throughput

0.536

High

552789

TPR
Nucleoprotein TPR

1

10

High-throughput

0.536

High

604806

HXB9
Homeobox protein Hox-B9

1

20

High-throughput

0.536

High

628753

TBP
TATA-box-binding protein

1

2

High-throughput

0.536

High

636840

GSTM3
Glutathione S-transferase Mu 3

1

4

High-throughput

0.536

High

703294

SMCA1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1

1

20

High-throughput

0.536

High

1029679

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

20

High-throughput

0.536

High

1029680

NC2A
Dr1-associated corepressor

1

9

High-throughput

0.536

High

1029683

RBBP5
Retinoblastoma-binding protein 5

1

4

High-throughput

0.536

High

1029684

TEAD2
Transcriptional enhancer factor TEF-4

1

2

High-throughput

0.536

High

711811

KDM5A
Lysine-specific demethylase 5A

1

7

High-throughput

0.536

High

814786

CUX1
Homeobox protein cut-like 1

1

20

High-throughput

0.536

High

892546

DNLI3
DNA ligase 3

1

5

High-throughput

0.536

High

926644

HIRA
Protein HIRA

1

10

High-throughput

0.536

High

943465

DSCR6
Protein ripply3

1

1

High-throughput

0.536

High

1010847

TMF1
TATA element modulatory factor

1

3

High-throughput

0.536

High

1029662

PPARD
Peroxisome proliferator-activated receptor delta

1

20

High-throughput

0.536

High

1029666

BPTF
Nucleosome-remodeling factor subunit BPTF

1

20

High-throughput

0.536

High

1029668

TP53B
TP53-binding protein 1

1

6

High-throughput

0.536

High

1029672

MTA1
Metastasis-associated protein MTA1

1

10

Small-scale

0.536

High

1029677

NFYC
Nuclear transcription factor Y subunit gamma

1

9

High-throughput

0.536

High

1029678

FHL2
Four and a half LIM domains protein 2

1

4

High-throughput

0.536

High

1029690

ARI4B
AT-rich interactive domain-containing protein 4B

1

20

High-throughput

0.536

High

1029692

BRM1L
Breast cancer metastasis-suppressor 1-like protein

1

8

High-throughput

0.536

High

1029693

UBR4
E3 ubiquitin-protein ligase UBR4

1

4

High-throughput

0.536

High

1029694

RBM26
RNA-binding protein 26

1

8

High-throughput

0.536

High

1029696

KANK2
KN motif and ankyrin repeat domain-containing protein 2

1

12

High-throughput

0.536

High

1029700

CTR9
RNA polymerase-associated protein CTR9 homolog

1

8

High-throughput

0.536

High

1029707

EMSY
BRCA2-interacting transcriptional repressor EMSY

1

16

High-throughput

0.536

High

1029708

TF2LX
Homeobox protein TGIF2LX

1

9

High-throughput

0.536

High

1029711

CLASR
CLK4-associating serine/arginine rich protein

1

2

High-throughput

0.536

High

1029712

SIR6
NAD-dependent protein deacylase sirtuin-6

1

12

High-throughput

0.536

High

1029722

EFMT3
EEF1A lysine methyltransferase 3

1

4

High-throughput

0.536

High

1029725

ZBT10
Zinc finger and BTB domain-containing protein 10

1

12

High-throughput

0.536

High

1029729

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

1

11

High-throughput

0.536

High

1029731

YTDC1
YTH domain-containing protein 1

1

2

High-throughput

0.536

High

1029737

MNT
Max-binding protein MNT

1

16

High-throughput

0.536

High

1029739

NPAS1
Neuronal PAS domain-containing protein 1

1

9

High-throughput

0.536

High

1029740

TBL1Y
F-box-like/WD repeat-containing protein TBL1Y

1

11

High-throughput

0.536

High

1029746

UBXN6
UBX domain-containing protein 6

1

1

High-throughput

0.536

High

1029747

DPY30
Protein dpy-30 homolog

1

1

High-throughput

0.536

High

1029753

ADNP
Activity-dependent neuroprotector homeobox protein

1

3

High-throughput

0.536

High

1029754

IKZF4
Zinc finger protein Eos

1

3

High-throughput

0.536

High

1029757

ZBTB3
Zinc finger and BTB domain-containing protein 3

1

13

High-throughput

0.536

High

1029758

RABE2
Rab GTPase-binding effector protein 2

1

5

High-throughput

0.536

High

1029760

SDS3
Sin3 histone deacetylase corepressor complex component SDS3

1

8

High-throughput

0.536

High

1029762

SP30L
Histone deacetylase complex subunit SAP30L

1

2

High-throughput

0.536

High

1029764

BRMS1
Breast cancer metastasis-suppressor 1

1

8

High-throughput

0.536

High

1029767

PRD10
PR domain zinc finger protein 10

1

1

High-throughput

0.536

High

1029768

ABHDA
Palmitoyl-protein thioesterase ABHD10, mitochondrial

1

1

High-throughput

0.536

High

1029769

NHP2
H/ACA ribonucleoprotein complex subunit 2

1

2

High-throughput

0.536

High

1029778

PUF60
Poly(U)-binding-splicing factor PUF60

1

5

High-throughput

0.536

High

1029780

HSPB8
Heat shock protein beta-8

1

3

High-throughput

0.536

High

1029784

TRI35
E3 ubiquitin-protein ligase TRIM35

1

3

High-throughput

0.536

High

1029785

SET1B
Histone-lysine N-methyltransferase SETD1B

1

8

Small-scale

0.536

High

1029786

SATB2
DNA-binding protein SATB2

1

20

High-throughput

0.536

High

1029790

TR150
Thyroid hormone receptor-associated protein 3

1

7

High-throughput

0.536

High

1029794

TF3C3
General transcription factor 3C polypeptide 3

1

11

High-throughput

0.536

High

231558

PRKY
Putative serine/threonine-protein kinase PRKY

1

11

High-throughput

0.514

High

134686

SAP18
Histone deacetylase complex subunit SAP18

1

0

High-throughput

0.513

High

1029669

REST
RE1-silencing transcription factor

1

0

Small-scale

0.513

High

1029687

NRF1
Nuclear respiratory factor 1

1

0

High-throughput

0.513

High

1029710

BAP18
BPTF-associated chromatin complex component 1

1

0

High-throughput

0.513

High

1029743

PHF23
PHD finger protein 23

1

0

High-throughput

0.513

High

1029759

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

0

High-throughput

0.513

High

1029761

KANL2
KAT8 regulatory NSL complex subunit 2

1

0

High-throughput

0.513

High

1029766

DMAP1
DNA methyltransferase 1-associated protein 1

1

0

High-throughput

0.513

High

1029772

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

1

0

High-throughput

0.513

High

1029664

RBBP4
Histone-binding protein RBBP4

1

6

Small-scale

0.501

High

952404

IL2
Interleukin-2

1

0

Small-scale

0.493

High

230007

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

9

High-throughput

0.489

High

243848

K0513
Uncharacterized protein KIAA0513

1

1

High-throughput

0.489

High

249928

NPHN
Nephrin

1

2

High-throughput

0.489

High

258108

IF2P
Eukaryotic translation initiation factor 5B

1

1

High-throughput

0.489

High

299971

CBPD
Carboxypeptidase D

1

4

High-throughput

0.489

High

420495

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

1

High-throughput

0.489

High

718386

CD6
T-cell differentiation antigen CD6

1

3

High-throughput

0.489

High

861123

MAP1B
Microtubule-associated protein 1B

1

12

High-throughput

0.489

High

945216

NU107
Nuclear pore complex protein Nup107

1

3

High-throughput

0.489

High

1029689

INF2
Inverted formin-2

1

2

High-throughput

0.489

High

1029691

AMOT
Angiomotin

1

12

High-throughput

0.489

High

1029695

FAXC
Failed axon connections homolog

1

1

High-throughput

0.489

High

1029697

BLT3A
Bridge-like lipid transfer protein family member 3A

1

1

High-throughput

0.489

High

1029699

PLBL1
Phospholipase B-like 1

1

1

High-throughput

0.489

High

1029713

ANR52
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C

1

5

High-throughput

0.489

High

1029716

RIN3
Ras and Rab interactor 3

1

9

High-throughput

0.489

High

1029717

NPRL2
GATOR1 complex protein NPRL2

1

1

High-throughput

0.489

High

1029727

ZB10P
Putative protein ZBED10P

1

1

High-throughput

0.489

High

1029732

CC85A
Coiled-coil domain-containing protein 85A

1

1

High-throughput

0.489

High

1029734

TCPQM
T-complex protein 1 subunit theta-like 2

1

3

High-throughput

0.489

High

1029750

DNAI2
Dynein axonemal intermediate chain 2

1

13

High-throughput

0.489

High

1029763

TANC2
Protein TANC2

1

7

High-throughput

0.489

High

1029777

HMGX4
HMG domain-containing protein 4

1

20

High-throughput

0.489

High

1029787

PSG11
Pregnancy-specific beta-1-glycoprotein 11

1

3

High-throughput

0.489

High

1029791

DOP1B
Protein DOP1B

1

1

High-throughput

0.489

High

1029796

SNX9
Sorting nexin-9

1

2

High-throughput

0.489

High

71441

P20L1
PHD finger protein 20-like protein 1

1

1

High-throughput

0.479

High

128979

MEN1
Menin

1

4

High-throughput

0.479

High

135175

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

19

High-throughput

0.479

High

142942

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.479

High

161447

KMT2D
Histone-lysine N-methyltransferase 2D

1

12

High-throughput

0.479

High

172710

XPO1
Exportin-1

1

13

High-throughput

0.479

High

194546

KDM6A
Lysine-specific demethylase 6A

1

9

Small-scale

0.479

High

209982

CRX
Cone-rod homeobox protein

1

20

High-throughput

0.479

High

338818

CBX6
Chromobox protein homolog 6

1

5

High-throughput

0.479

High

339722

KLF8
Krueppel-like factor 8

1

15

High-throughput

0.479

High

406079

MYCN
N-myc proto-oncogene protein

1

10

High-throughput

0.479

High

473919

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

685159

PAX6
Paired box protein Pax-6

1

14

High-throughput

0.479

High

703120

TEAD1
Transcriptional enhancer factor TEF-1

1

2

High-throughput

0.479

High

771582

HXD13
Homeobox protein Hox-D13

1

20

High-throughput

0.479

High

775822

HNF1B
Hepatocyte nuclear factor 1-beta

1

18

High-throughput

0.479

High

833919

HNF4A
Hepatocyte nuclear factor 4-alpha

1

20

High-throughput

0.479

High

883505

CENPA
Histone H3-like centromeric protein A

1

10

High-throughput

0.479

High

886763

CEBPA
CCAAT/enhancer-binding protein alpha

1

11

High-throughput

0.479

High

944629

KLF3
Krueppel-like factor 3

1

13

High-throughput

0.479

High

979513

H4
Histone H4

1

6

High-throughput

0.479

High

986347

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

5

High-throughput

0.479

High

998220

H31
Histone H3.1

1

10

High-throughput

0.479

High

1016780

H33
Histone H3.3

1

10

High-throughput

0.479

High

1024512

VIGLN
Vigilin

1

13

High-throughput

0.479

High

1029661

HEN1
Helix-loop-helix protein 1

1

2

High-throughput

0.479

High

1029665

EP300
Histone acetyltransferase p300

1

20

High-throughput

0.479

High

1029667

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

1029673

CTBP1
C-terminal-binding protein 1

1

7

High-throughput

0.479

High

1029685

ZYX
Zyxin

1

7

High-throughput

0.479

High

1029706

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.479

High

1029714

KDM1B
Lysine-specific histone demethylase 2

1

2

High-throughput

0.479

High

1029715

NUP35
Nucleoporin NUP35

1

2

High-throughput

0.479

High

1029720

KAT6A
Histone acetyltransferase KAT6A

1

18

High-throughput

0.479

High

1029724

MBD6
Methyl-CpG-binding domain protein 6

1

8

High-throughput

0.479

High

1029738

BARD1
BRCA1-associated RING domain protein 1

1

9

Small-scale

0.479

High

1029744

KLF16
Krueppel-like factor 16

1

10

High-throughput

0.479

High

1029748

ASXL3
Putative Polycomb group protein ASXL3

1

11

Small-scale

0.479

High

1029771

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

1

High-throughput

0.479

High

1029776

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

11

High-throughput

0.479

High

1029779

XPO7
Exportin-7

1

11

High-throughput

0.479

High

1029792

ZN330
Zinc finger protein 330

1

1

High-throughput

0.479

High

378486

IL1A
Interleukin-1 alpha

1

0

Small-scale

0.458

High

1029789

ASF1A
Histone chaperone ASF1A

1

0

High-throughput

0.458

High

1029688

DDR2
Discoidin domain-containing receptor 2

1

6

High-throughput

0.457

High

107428

F8W9L8
PHD finger protein 20-like protein 1

1

1

High-throughput

0.445

High

109548

G5E9I4
BRMS1 transcriptional repressor and anoikis regulator

1

8

High-throughput

0.445

High

166517

BACH1
Transcription regulator protein BACH1

1

11

High-throughput

0.445

High

725176

HXC13
Homeobox protein Hox-C13

1

20

High-throughput

0.445

High

848772

MAGAA
Melanoma-associated antigen 10

1

4

High-throughput

0.445

High

1029671

SRSF5
Serine/arginine-rich splicing factor 5

1

6

High-throughput

0.445

High

1029749

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

4

High-throughput

0.445

High

1029783

KMT2B
Histone-lysine N-methyltransferase 2B

1

9

High-throughput

0.445

High

105769

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

942560

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

7

High-throughput

0.437

High

1029702

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.437

High

1029770

MTMR4
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4

1

2

High-throughput

0.437

High

1029775

HECW2
E3 ubiquitin-protein ligase HECW2

1

5

High-throughput

0.437

High

1029793

PRC2C
Protein PRRC2C

1

16

High-throughput

0.437

High

1029675

XRCC4
DNA repair protein XRCC4

1

0

High-throughput

0.426

High

1029795

TSSC4
U5 small nuclear ribonucleoprotein TSSC4

1

0

High-throughput

0.426

High

64176

ARG35
Rho guanine nucleotide exchange factor 35

1

1

High-throughput

0.407

High

1029698

ARMC6
Armadillo repeat-containing protein 6

1

1

High-throughput

0.407

High

1029701

PKHG7
Pleckstrin homology domain-containing family G member 7

1

1

High-throughput

0.407

High

1029741

GORS1
Golgi reassembly-stacking protein 1

1

1

High-throughput

0.407

High

1029756

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

4

High-throughput

0.407

High

298160

DCTN3
Dynactin subunit 3

1

0

High-throughput

0.279

Low

1029704

RSRC2
Arginine/serine-rich coiled-coil protein 2

1

0

High-throughput

0.279

Low

1029730

CXD4
Gap junction delta-4 protein

1

0

High-throughput

0.279

Low

1029736

SEC62
Translocation protein SEC62

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025