HitPredict

Interactor 1: BRD4 (O60885)
Bromodomain-containing protein 4 (Protein HUNK1)
Gene: BRD4

Interactor 2: TIF1B (Q13263)
Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28)
Gene: TRIM28

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	31239290, 32416067, 30554943
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Bromodomain~PHD
Common GO terms	GO:0003682 - chromatin binding GO:0003713 - transcription coactivator activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 1362 Hs			1 835
+	Hs
		243985 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		PML_HUMAN (29-609): 1.21e-57: 214: 14.00
+	Hs
		244755 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		TRI63_HUMAN (53-406): 8.26e-61: 211: 15.56
+	Hs
		245097 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		TRI33_HUMAN (406-826): 1.6e-54: 206: 19.32
+	Hs
		244865 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		TRI56_HUMAN (47-532): 1.21e-51: 195: 17.68
+	Hs
		244895 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		TRI55_HUMAN (41-610): 9.71e-50: 186: 14.21
+	Hs
		243914 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		RO52_HUMAN (104-502): 1.58e-48: 180: 12.94
+	Hs
		170259 BRD2_HUMAN (3-737): 2.87e-55: 209: 46.43		TIF1A_HUMAN (404-808): 1.31e-52: 200: 21.55
+	Hs
		319130 BRD1_HUMAN (197-781): 8.89e-33: 140: 13.99		PML_HUMAN (29-609): 1.21e-57: 214: 14.00
+	Hs
		319383 BRD1_HUMAN (197-781): 8.89e-33: 140: 13.99		TRI33_HUMAN (406-826): 1.6e-54: 206: 19.32
+	Hs
		668856 PHIP_HUMAN (26-669): 5.56e-18: 92.9: 13.30		PML_HUMAN (29-609): 1.21e-57: 214: 14.00
+	Hs
		1199218 PB1_HUMAN (26-956): 2.35e-19: 97.1: 10.81		TRI33_HUMAN (406-826): 1.6e-54: 206: 19.32
+	Hs
		1282053 BRWD1_HUMAN (295-501): 2.62e-13: 77.5: 16.91		TRI63_HUMAN (53-406): 8.26e-61: 211: 15.56
+	Hs
		1017367 BPTF_HUMAN (67-161): 9.86e-11: 68.9: 41.05		TRI33_HUMAN (406-826): 1.6e-54: 206: 19.32
+	Hs
		164439 PHIP_HUMAN (26-669): 5.56e-18: 92.9: 13.30		TRI66_HUMAN (335-810): 2.93e-45: 178: 19.00
+	Hs
		1317522 BRWD1_HUMAN (295-501): 2.62e-13: 77.5: 16.91		TRI55_HUMAN (41-610): 9.71e-50: 186: 14.21