Protein: NPA1P
Nucleolar pre-ribosomal-associated protein 1 (Nucleolar protein 254 kDa) (URB1 ribosome biogenesis 1 homolog)

Gene: NPA1P, URB1
Organism: Homo sapiens
Interactions: 143
UniProt ID: O60287

Gene Ontology (top 5):
GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0001650 - fibrillar center
GO:0003723 - RNA binding
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

244303

NPM
Nucleophosmin

5

1

High-throughput

0.712

High

208145

RRP8
Ribosomal RNA-processing protein 8

3

0

High-throughput

0.634

High

244332

RBM34
RNA-binding protein 34

2

1

High-throughput

0.628

High

244401

RBM4
RNA-binding protein 4

2

1

High-throughput

0.628

High

140675

NOP56
Nucleolar protein 56

2

2

High-throughput

0.611

High

244339

MECP2
Methyl-CpG-binding protein 2

2

0

High-throughput

0.602

High

244351

RL18A
Large ribosomal subunit protein eL20

2

0

High-throughput

0.602

High

244352

RL18
Large ribosomal subunit protein eL18

2

0

High-throughput

0.602

High

244371

NOL8
Nucleolar protein 8

2

0

High-throughput

0.602

High

244415

TAP26
Thyroid transcription factor 1-associated protein 26

2

0

High-throughput

0.602

High

244296

NPM3
Nucleoplasmin-3

2

1

High-throughput

0.601

High

244302

RLA0
Large ribosomal subunit protein uL10

2

2

High-throughput

0.601

High

244299

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

4

High-throughput

0.584

High

244316

FBRL
rRNA 2'-O-methyltransferase fibrillarin

2

1

High-throughput

0.584

High

244297

SURF6
Surfeit locus protein 6

2

0

High-throughput

0.576

High

244307

FGF3
Fibroblast growth factor 3

2

2

High-throughput

0.574

High

244341

FGF8
Fibroblast growth factor 8

2

2

High-throughput

0.574

High

244416

H2AW
Core histone macro-H2A.2

2

1

High-throughput

0.574

High

244300

MYC
Myc proto-oncogene protein

2

0

High-throughput

0.559

High

244345

RS6
Small ribosomal subunit protein eS6

2

0

High-throughput

0.559

High

244315

FPR1
fMet-Leu-Phe receptor

2

1

High-throughput

0.549

High

74403

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

1

High-throughput

0.536

High

244295

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

1

4

High-throughput

0.536

High

244330

RL13A
Large ribosomal subunit protein uL13

1

1

High-throughput

0.536

High

244331

MNDA
Myeloid cell nuclear differentiation antigen

1

1

High-throughput

0.536

High

244333

NOP2
28S rRNA

1

1

High-throughput

0.536

High

244350

RED1
Double-stranded RNA-specific editase 1

1

2

High-throughput

0.536

High

244353

ILF3
Interleukin enhancer-binding factor 3

1

2

High-throughput

0.536

High

244354

SRSF6
Serine/arginine-rich splicing factor 6

1

2

High-throughput

0.536

High

244380

DDX55
ATP-dependent RNA helicase DDX55

1

3

High-throughput

0.536

High

244301

ESR1
Estrogen receptor

2

1

High-throughput

0.521

High

244310

H12
Histone H1.2

1

0

High-throughput

0.513

High

244313

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

0

High-throughput

0.513

High

244320

RL13
Large ribosomal subunit protein eL13

1

0

High-throughput

0.513

High

244326

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.513

High

244335

RL28
Large ribosomal subunit protein eL28

1

0

High-throughput

0.513

High

244343

RL15
Large ribosomal subunit protein eL15

1

0

High-throughput

0.513

High

244344

RS14
Small ribosomal subunit protein uS11

1

0

High-throughput

0.513

High

244399

LLPH
Protein LLP homolog

1

0

High-throughput

0.513

High

244410

DDX21
Nucleolar RNA helicase 2

1

0

High-throughput

0.513

High

244412

ABC3C
DNA dC->dU-editing enzyme APOBEC-3C

1

0

High-throughput

0.513

High

244420

ABT1
Activator of basal transcription 1

1

0

High-throughput

0.513

High

244424

RL36
Large ribosomal subunit protein eL36

1

0

High-throughput

0.513

High

182426

GP182
G-protein coupled receptor 182

1

2

High-throughput

0.489

High

244378

DDX60
Probable ATP-dependent RNA helicase DDX60

1

1

High-throughput

0.489

High

244385

FGF13
Fibroblast growth factor 13

1

2

High-throughput

0.489

High

244329

RL3
Large ribosomal subunit protein uL3

1

1

High-throughput

0.479

High

244349

RL10A
Large ribosomal subunit protein uL1

1

2

High-throughput

0.479

High

244366

IF16
Gamma-interferon-inducible protein 16

1

1

High-throughput

0.479

High

244377

DHX40
Probable ATP-dependent RNA helicase DHX40

1

3

High-throughput

0.479

High

244403

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

1

High-throughput

0.479

High

244411

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

1

High-throughput

0.479

High

190750

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.458

High

244305

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.458

High

244322

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

High-throughput

0.458

High

244325

RL22
Large ribosomal subunit protein eL22

1

0

High-throughput

0.458

High

244328

COIL
Coilin

1

0

High-throughput

0.458

High

244338

RL14
Large ribosomal subunit protein eL14

1

0

High-throughput

0.458

High

244342

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.458

High

244346

H4
Histone H4

1

0

High-throughput

0.458

High

244347

RS24
Small ribosomal subunit protein eS24

1

0

High-throughput

0.458

High

244348

RL31
Large ribosomal subunit protein eL31

1

0

High-throughput

0.458

High

244373

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

High-throughput

0.458

High

244382

H1X
Histone H1.10

1

0

High-throughput

0.458

High

244388

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

0

High-throughput

0.458

High

244398

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

0

High-throughput

0.458

High

244400

DDX23
Probable ATP-dependent RNA helicase DDX23

1

0

High-throughput

0.458

High

244404

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

0

High-throughput

0.458

High

244417

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

0

High-throughput

0.458

High

244421

RL26L
Ribosomal protein uL24-like

1

0

High-throughput

0.458

High

244423

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

244359

DHX8
ATP-dependent RNA helicase DHX8

1

3

High-throughput

0.445

High

244360

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

1

High-throughput

0.445

High

244298

KI20A
Kinesin-like protein KIF20A

1

1

High-throughput

0.437

High

244312

VGFR1
Vascular endothelial growth factor receptor 1

1

1

High-throughput

0.437

High

244327

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

1

High-throughput

0.437

High

244336

CENPA
Histone H3-like centromeric protein A

1

1

High-throughput

0.437

High

244383

ESR2
Estrogen receptor beta

1

1

High-throughput

0.437

High

244311

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

High-throughput

0.426

High

244362

MO4L2
Mortality factor 4-like protein 2

1

0

High-throughput

0.426

High

244337

CXCR3
C-X-C chemokine receptor type 3

1

1

High-throughput

0.407

High

244375

LRRT3
Leucine-rich repeat transmembrane neuronal protein 3

1

1

High-throughput

0.407

High

244367

PKHO1
Pleckstrin homology domain-containing family O member 1

2

0

High-throughput

0.328

High

244392

ZN512
Zinc finger protein 512

2

0

High-throughput

0.328

High

244363

KIF14
Kinesin-like protein KIF14

2

0

High-throughput

0.318

High

191489

MAGB2
Melanoma-associated antigen B2

2

0

High-throughput

0.313

High

244355

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

2

0

High-throughput

0.313

High

244304

TACD2
Tumor-associated calcium signal transducer 2

1

0

High-throughput

0.279

Low

244318

KALM
Anosmin-1

1

0

High-throughput

0.279

Low

244334

BAG6
Large proline-rich protein BAG6

1

0

High-throughput

0.279

Low

244340

EFNA4
Ephrin-A4

1

0

High-throughput

0.279

Low

244357

DGKZ
Diacylglycerol kinase zeta

1

0

High-throughput

0.279

Low

244358

FGFP1
Fibroblast growth factor-binding protein 1

1

0

High-throughput

0.279

Low

244374

ZN467
Zinc finger protein 467

1

0

High-throughput

0.279

Low

244384

TFG
Protein TFG

1

0

High-throughput

0.279

Low

244387

ZN653
Zinc finger protein 653

1

0

High-throughput

0.279

Low

244389

NEIL1
Endonuclease 8-like 1

1

0

High-throughput

0.279

Low

244390

ZN668
Zinc finger protein 668

1

0

High-throughput

0.279

Low

244393

ZNF48
Zinc finger protein 48

1

0

High-throughput

0.279

Low

244394

NLRP3
NACHT, LRR and PYD domains-containing protein 3

1

0

High-throughput

0.279

Low

244397

SORT
Sortilin

1

0

High-throughput

0.279

Low

244408

TF7L2
Transcription factor 7-like 2

1

0

High-throughput

0.279

Low

244414

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.279

Low

244418

CDC23
Cell division cycle protein 23 homolog

1

0

High-throughput

0.279

Low

244422

SRPK3
SRSF protein kinase 3

1

0

High-throughput

0.279

Low

244364

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

0

High-throughput

0.265

Low

244365

MK06
Mitogen-activated protein kinase 6

1

0

High-throughput

0.265

Low

125095

LEG9
Galectin-9

1

0

High-throughput

0.249

Low

128648

MEN1
Menin

1

0

High-throughput

0.249

Low

156741

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.249

Low

222561

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.249

Low

244293

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.249

Low

244294

DNJB6
DnaJ homolog subfamily B member 6

1

0

High-throughput

0.249

Low

244306

H2AB2
Histone H2A-Bbd type 2/3

1

0

High-throughput

0.249

Low

244308

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

244309

NCK1
SH2/SH3 adapter protein NCK1

1

0

High-throughput

0.249

Low

244321

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

244324

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

244356

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.249

Low

244361

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.249

Low

244368

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.249

Low

244369

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

244370

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

244381

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.249

Low

244386

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.249

Low

244391

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.249

Low

244395

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

0

High-throughput

0.249

Low

244402

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

0

High-throughput

0.249

Low

244405

ATG5
Autophagy protein 5

1

0

High-throughput

0.249

Low

244406

CHM4B
Charged multivesicular body protein 4b

1

0

High-throughput

0.249

Low

244409

ANLN
Anillin

1

0

High-throughput

0.249

Low

244413

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.249

Low

244419

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

High-throughput

0.249

Low

50452

HACL2
2-hydroxyacyl-CoA lyase 2

1

0

High-throughput

0.232

Low

244314

CAP7
Azurocidin

1

0

High-throughput

0.232

Low

244317

GNLY
Granulysin

1

0

High-throughput

0.232

Low

244319

TNR5
Tumor necrosis factor receptor superfamily member 5

1

0

High-throughput

0.232

Low

244323

5HT1E
5-hydroxytryptamine receptor 1E

1

0

High-throughput

0.232

Low

244372

RIC3
Protein RIC-3

1

0

High-throughput

0.232

Low

244376

VSIG1
V-set and immunoglobulin domain-containing protein 1

1

0

High-throughput

0.232

Low

244379

UXS1
UDP-glucuronic acid decarboxylase 1

1

0

High-throughput

0.232

Low

244396

S1PR3
Sphingosine 1-phosphate receptor 3

1

0

High-throughput

0.232

Low

244407

TMM9B
Transmembrane protein 9B

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025