HitPredict

Interactor 1: BRD4 (O60885)
Bromodomain-containing protein 4 (Protein HUNK1)
Gene: BRD4

Interactor 2: SIR5 (Q9NXA8)
NAD-dependent protein deacylase sirtuin-5, mitochondrial (EC 2.3.1.-) (Regulatory protein SIR2 homolog 5) (SIR2-like protein 5)
Gene: SIRT5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	21555454
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 1362 Hs			1 310
+	Hs
		244768 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		SIR1_HUMAN (35-305): 3.57e-88: 280: 27.14
+	Hs
		244666 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		SIR6_HUMAN (18-301): 2.1e-90: 275: 19.66
+	Hs
		244985 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		SIR7_HUMAN (4-302): 3.63e-81: 253: 21.29
+	Hs
		319299 BRD1_HUMAN (197-781): 8.89e-33: 140: 13.99		SIR1_HUMAN (35-305): 3.57e-88: 280: 27.14
+	Hs
		1271483 KAT2B_HUMAN (327-456): 5.61e-22: 105: 26.92		SIR1_HUMAN (35-305): 3.57e-88: 280: 27.14
+	Hs
		1271439 KAT2A_HUMAN (327-456): 1.76e-20: 100: 26.15		SIR1_HUMAN (35-305): 3.57e-88: 280: 27.14
+	Hs
		1199159 PB1_HUMAN (26-956): 2.35e-19: 97.1: 10.81		SIR6_HUMAN (18-301): 2.1e-90: 275: 19.66
+	Hs
		1220752 KAT2B_HUMAN (327-456): 5.61e-22: 105: 26.92		SIR2_HUMAN (35-285): 2.48e-85: 263: 24.34
+	Hs
		1220751 KAT2A_HUMAN (327-456): 1.76e-20: 100: 26.15		SIR2_HUMAN (35-285): 2.48e-85: 263: 24.34
+	Hs
		1271503 KAT2B_HUMAN (327-456): 5.61e-22: 105: 26.92		SIR7_HUMAN (4-302): 3.63e-81: 253: 21.29
+	Hs
		1199203 PB1_HUMAN (26-956): 2.35e-19: 97.1: 10.81		SIR7_HUMAN (4-302): 3.63e-81: 253: 21.29
+	Hs
		1262825 PHIP_HUMAN (26-669): 5.56e-18: 92.9: 13.30		SIR7_HUMAN (4-302): 3.63e-81: 253: 21.29
+	Hs
		1017354 BPTF_HUMAN (67-161): 9.86e-11: 68.9: 41.05		SIR7_HUMAN (4-302): 3.63e-81: 253: 21.29