Protein: KMT2D
Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2)

Gene: KMT2D
Organism: Homo sapiens
Interactions: 165
UniProt ID: O14686

Gene Ontology (top 5):
GO:0000976 - transcription cis-regulatory region binding
GO:0001555 - oocyte growth
GO:0003677 - DNA binding
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

161520

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

17

20

Small-scale

0.986

High

161472

RBBP5
Retinoblastoma-binding protein 5

17

20

Small-scale

0.983

High

161374

KDM6A
Lysine-specific demethylase 6A

6

20

Small-scale

0.935

High

161444

H4
Histone H4

4

13

Small-scale

0.888

High

161502

FBXW7
F-box/WD repeat-containing protein 7

3

20

Small-scale

0.853

High

161443

WDR5
WD repeat-containing protein 5

26

20

Small-scale

0.767

High

161371

SET1A
Histone-lysine N-methyltransferase SETD1A

2

20

High-throughput

0.754

High

161451

KMT2A
Histone-lysine N-methyltransferase 2A

2

20

Small-scale

0.754

High

161518

CXXC1
CXXC-type zinc finger protein 1

2

20

Small-scale

0.754

High

161499

CBP
CREB-binding protein

1

20

Small-scale

0.724

High

161399

ANDR
Androgen receptor

5

20

Small-scale

0.709

High

161509

PAGR1
PAXIP1-associated glutamate-rich protein 1

5

2

Small-scale

0.703

High

158679

UTY
Histone demethylase UTY

1

20

High-throughput

0.691

High

161487

RBM45
RNA-binding protein 45

1

9

High-throughput

0.691

High

161507

PYGO2
Pygopus homolog 2

1

0

Small-scale

0.687

High

161483

PAXI1
PAX-interacting protein 1

4

20

Small-scale

0.678

High

161393

GCR
Glucocorticoid receptor

4

20

Small-scale

0.676

High

161467

NCOA6
Nuclear receptor coactivator 6

4

20

Small-scale

0.666

High

161394

H2A1B
Histone H2A type 1-B/E

1

19

Small-scale

0.647

High

161411

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

15

Small-scale

0.647

High

161419

H2B1B
Histone H2B type 1-B

1

20

Small-scale

0.647

High

161446

H31
Histone H3.1

1

20

Small-scale

0.647

High

161484

H32
Histone H3.2

1

20

Small-scale

0.647

High

128612

MEN1
Menin

3

9

Small-scale

0.640

High

161392

ESR1
Estrogen receptor

2

20

Small-scale

0.629

High

161377

BUB3
Mitotic checkpoint protein BUB3

1

20

High-throughput

0.618

High

161385

KDM4B
Lysine-specific demethylase 4B

1

11

Small-scale

0.618

High

161416

KDM5A
Lysine-specific demethylase 5A

1

20

Small-scale

0.618

High

161453

TLE3
Transducin-like enhancer protein 3

1

20

High-throughput

0.618

High

161457

EP300
Histone acetyltransferase p300

1

20

Small-scale

0.618

High

161461

HDAC1
Histone deacetylase 1

1

20

High-throughput

0.618

High

161471

SUZ12
Polycomb protein SUZ12

1

9

High-throughput

0.618

High

161476

EZH2
Histone-lysine N-methyltransferase EZH2

1

18

High-throughput

0.618

High

161481

WDR82
WD repeat-containing protein 82

1

20

Small-scale

0.618

High

161491

KMT2C
Histone-lysine N-methyltransferase 2C

1

20

High-throughput

0.618

High

161493

NUP43
Nucleoporin Nup43

1

20

High-throughput

0.618

High

161503

PF21A
PHD finger protein 21A

1

20

High-throughput

0.618

High

161506

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

20

Small-scale

0.618

High

161525

KMT2B
Histone-lysine N-methyltransferase 2B

1

19

High-throughput

0.618

High

161526

SET1B
Histone-lysine N-methyltransferase SETD1B

1

20

High-throughput

0.618

High

161464

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

2

11

High-throughput

0.611

High

161420

CTNB1
Catenin beta-1

2

15

Small-scale

0.602

High

161458

NFIA
Nuclear factor 1 A-type

2

20

High-throughput

0.601

High

161470

NFIX
Nuclear factor 1 X-type

2

20

High-throughput

0.601

High

142711

NFIB
Nuclear factor 1 B-type

2

20

High-throughput

0.584

High

161396

NFIC
Nuclear factor 1 C-type

2

20

High-throughput

0.584

High

161430

YAP1
Transcriptional coactivator YAP1

2

20

Small-scale

0.584

High

161431

SOX2
Transcription factor SOX-2

2

20

Small-scale

0.584

High

161442

KLF3
Krueppel-like factor 3

2

20

High-throughput

0.584

High

161480

WDR74
WD repeat-containing protein 74

1

20

High-throughput

0.575

High

161511

DPY30
Protein dpy-30 homolog

2

7

Small-scale

0.571

High

161418

AKT1
RAC-alpha serine/threonine-protein kinase

1

3

Small-scale

0.561

High

161452

TF65
Transcription factor p65

1

14

Small-scale

0.561

High

161445

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

9

High-throughput

0.536

High

161429

KI67
Proliferation marker protein Ki-67

1

16

High-throughput

0.536

High

161456

GOGA2
Golgin subfamily A member 2

2

10

High-throughput

0.533

High

161477

SEPT7
Septin-7

1

6

High-throughput

0.515

High

161490

POC1A
POC1 centriolar protein homolog A

1

20

High-throughput

0.514

High

161373

SMAD9
Mothers against decapentaplegic homolog 9

1

14

High-throughput

0.508

High

161475

SMAD1
Mothers against decapentaplegic homolog 1

1

14

High-throughput

0.508

High

161389

ABL1
Tyrosine-protein kinase ABL1

1

18

High-throughput

0.501

High

161397

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

10

High-throughput

0.501

High

161500

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

13

High-throughput

0.501

High

161438

MANF
Mesencephalic astrocyte-derived neurotrophic factor

1

0

High-throughput

0.493

High

161415

S10A2
Protein S100-A2

1

8

High-throughput

0.489

High

124553

EYA2
Protein phosphatase EYA2

1

17

High-throughput

0.479

High

130304

SPT5H
Transcription elongation factor SPT5

1

20

High-throughput

0.479

High

143366

E2F3
Transcription factor E2F3

1

12

Small-scale

0.479

High

161372

TBXT
T-box transcription factor T

1

7

High-throughput

0.479

High

161375

CRX
Cone-rod homeobox protein

1

20

High-throughput

0.479

High

161376

KLF4
Krueppel-like factor 4

1

20

High-throughput

0.479

High

161378

TLX3
T-cell leukemia homeobox protein 3

1

20

High-throughput

0.479

High

161379

TLX2
T-cell leukemia homeobox protein 2

1

20

High-throughput

0.479

High

161380

SOX15
Transcription factor SOX-15

1

20

High-throughput

0.479

High

161382

KDM1A
Lysine-specific histone demethylase 1A

1

18

High-throughput

0.479

High

161383

E2F6
Transcription factor E2F6

1

12

Small-scale

0.479

High

161386

TRI37
E3 ubiquitin-protein ligase TRIM37

1

17

High-throughput

0.479

High

161387

KLF8
Krueppel-like factor 8

1

20

High-throughput

0.479

High

161388

HERC2
E3 ubiquitin-protein ligase HERC2

1

10

High-throughput

0.479

High

161390

FOS
Protein c-Fos

1

9

High-throughput

0.479

High

161391

IL1A
Interleukin-1 alpha

1

2

Small-scale

0.479

High

161395

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.479

High

161398

MYB
Transcriptional activator Myb

1

10

High-throughput

0.479

High

161400

EGR2
E3 SUMO-protein ligase EGR2

1

9

High-throughput

0.479

High

161401

ERG
Transcriptional regulator ERG

1

20

High-throughput

0.479

High

161402

HXB2
Homeobox protein Hox-B2

1

20

High-throughput

0.479

High

161403

ETS1
Protein C-ets-1

1

20

High-throughput

0.479

High

161404

MYOD1
Myoblast determination protein 1

1

15

High-throughput

0.479

High

161405

RFA2
Replication protein A 32 kDa subunit

1

7

High-throughput

0.479

High

161406

GATA1
Erythroid transcription factor

1

16

High-throughput

0.479

High

161407

HNF1A
Hepatocyte nuclear factor 1-alpha

1

4

High-throughput

0.479

High

161408

PAX7
Paired box protein Pax-7

1

20

High-throughput

0.479

High

161409

GATA2
Endothelial transcription factor GATA-2

1

16

High-throughput

0.479

High

161410

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

16

High-throughput

0.479

High

161412

PAX6
Paired box protein Pax-6

1

20

High-throughput

0.479

High

161413

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

9

High-throughput

0.479

High

161414

TEAD1
Transcriptional enhancer factor TEF-1

1

4

High-throughput

0.479

High

161417

TLX1
T-cell leukemia homeobox protein 1

1

20

High-throughput

0.479

High

161421

RFA3
Replication protein A 14 kDa subunit

1

6

High-throughput

0.479

High

161422

HNF1B
Hepatocyte nuclear factor 1-beta

1

20

High-throughput

0.479

High

161423

SOX5
Transcription factor SOX-5

1

20

High-throughput

0.479

High

161424

PPARG
Peroxisome proliferator-activated receptor gamma

1

20

High-throughput

0.479

High

161425

ETV5
ETS translocation variant 5

1

20

High-throughput

0.479

High

161426

HNF4A
Hepatocyte nuclear factor 4-alpha

1

20

High-throughput

0.479

High

161428

ETV4
ETS translocation variant 4

1

20

High-throughput

0.479

High

161432

SOX9
Transcription factor SOX-9

1

20

High-throughput

0.479

High

161433

LHX1
LIM/homeobox protein Lhx1

1

20

High-throughput

0.479

High

161434

CEBPA
CCAAT/enhancer-binding protein alpha

1

14

High-throughput

0.479

High

161436

LHX2
LIM/homeobox protein Lhx2

1

20

High-throughput

0.479

High

161437

HCFC1
Host cell factor 1

1

20

High-throughput

0.479

High

161439

PAX9
Paired box protein Pax-9

1

20

High-throughput

0.479

High

161440

SOX10
Transcription factor SOX-10

1

20

High-throughput

0.479

High

161441

GSC
Homeobox protein goosecoid

1

18

High-throughput

0.479

High

161447

FOXK2
Forkhead box protein K2

1

12

High-throughput

0.479

High

161448

IRF8
Interferon regulatory factor 8

1

7

High-throughput

0.479

High

161449

HEN1
Helix-loop-helix protein 1

1

11

High-throughput

0.479

High

161450

PAX2
Paired box protein Pax-2

1

20

High-throughput

0.479

High

161454

HME1
Homeobox protein engrailed-1

1

18

High-throughput

0.479

High

161455

PAX8
Paired box protein Pax-8

1

20

High-throughput

0.479

High

161459

FOXI1
Forkhead box protein I1

1

10

High-throughput

0.479

High

161460

FOXL1
Forkhead box protein L1

1

10

High-throughput

0.479

High

161463

CUL3
Cullin-3

1

15

High-throughput

0.479

High

161465

KLF5
Krueppel-like factor 5

1

20

High-throughput

0.479

High

161466

E2F2
Transcription factor E2F2

1

12

Small-scale

0.479

High

161468

STAT4
Signal transducer and activator of transcription 4

1

2

High-throughput

0.479

High

161469

MEF2D
Myocyte-specific enhancer factor 2D

1

2

Small-scale

0.479

High

161473

IRF4
Interferon regulatory factor 4

1

7

High-throughput

0.479

High

161474

E2F5
Transcription factor E2F5

1

12

Small-scale

0.479

High

161478

TBR1
T-box brain protein 1

1

7

High-throughput

0.479

High

161479

LHX8
LIM/homeobox protein Lhx8

1

20

High-throughput

0.479

High

161485

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

13

High-throughput

0.479

High

161488

SRRM1
Serine/arginine repetitive matrix protein 1

1

20

High-throughput

0.479

High

161492

BD1L1
Biorientation of chromosomes in cell division protein 1-like 1

1

20

High-throughput

0.479

High

161494

NUP35
Nucleoporin NUP35

1

2

High-throughput

0.479

High

161495

SP7
Transcription factor Sp7

1

20

High-throughput

0.479

High

161498

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

161501

LHX4
LIM/homeobox protein Lhx4

1

20

High-throughput

0.479

High

161504

FEV
Protein FEV

1

20

High-throughput

0.479

High

161505

ELF4
ETS-related transcription factor Elf-4

1

20

High-throughput

0.479

High

161508

SOX7
Transcription factor SOX-7

1

20

High-throughput

0.479

High

161510

KLF16
Krueppel-like factor 16

1

20

High-throughput

0.479

High

161512

WWTR1
WW domain-containing transcription regulator protein 1

1

19

High-throughput

0.479

High

161513

SENP3
Sentrin-specific protease 3

1

4

Small-scale

0.479

High

161514

SOX17
Transcription factor SOX-17

1

20

High-throughput

0.479

High

161515

GCM1
Chorion-specific transcription factor GCMa

1

2

High-throughput

0.479

High

161521

LHX3
LIM/homeobox protein Lhx3

1

20

High-throughput

0.479

High

161522

KLF15
Krueppel-like factor 15

1

20

High-throughput

0.479

High

161523

RCOR1
REST corepressor 1

1

20

High-throughput

0.479

High

161524

ELF5
ETS-related transcription factor Elf-5

1

20

High-throughput

0.479

High

161528

ASF1A
Histone chaperone ASF1A

1

6

High-throughput

0.479

High

161529

HCFC2
Host cell factor 2

1

20

High-throughput

0.479

High

161496

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

0

High-throughput

0.458

High

161497

TOPB1
DNA topoisomerase 2-binding protein 1

1

15

Small-scale

0.457

High

161427

MATR3
Matrin-3

1

6

Small-scale

0.445

High

161462

SNW1
SNW domain-containing protein 1

1

3

High-throughput

0.445

High

161517

GRHL1
Grainyhead-like protein 1 homolog

1

4

High-throughput

0.445

High

161384

NU155
Nuclear pore complex protein Nup155

1

1

High-throughput

0.437

High

161516

ALG13
UDP-N-acetylglucosamine transferase subunit ALG13

1

12

High-throughput

0.437

High

161519

SYLC
Leucine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.437

High

161381

KATIP
Katanin-interacting protein

1

0

High-throughput

0.426

High

161486

WDR5B
WD repeat-containing protein 5B

1

20

Small-scale

0.407

High

161527

ITM2B
Integral membrane protein 2B

1

3

High-throughput

0.407

High

161482

PPR21
Protein phosphatase 1 regulatory subunit 21

1

0

High-throughput

0.279

Low

161489

UBAC2
Ubiquitin-associated domain-containing protein 2

1

0

High-throughput

0.279

Low

161435

NDUV1
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025