HitPredict

Interactor 1: BRD4 (O60885)
Bromodomain-containing protein 4 (Protein HUNK1)
Gene: BRD4

Interactor 2: BICRA (Q9NZM4)
BRD4-interacting chromatin-remodeling complex-associated protein (Glioma tumor suppressor candidate region gene 1 protein)
Gene: BICRA

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.676

Property	Details
Experiments	29374058, 30554943, 35987950, 21555454
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0006338 - chromatin remodeling GO:0006357 - regulation of transcription by RNA polymerase II GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1362 Hs			1 1560
+	Hs
		631612 BRD2_HUMAN (3-737): 2.87e-55: 209: 46.43		BICRA_HUMAN (1-1560): 1.85e-111: 390: 100.00
+	Hs
		1067168 BRD3_HUMAN (37-738): 5.99e-55: 207: 47.53		BICRA_HUMAN (1-1560): 1.85e-111: 390: 100.00
+	Hs
		243903 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		SON_HUMAN (60-1516): 8.3e-31: 135: 10.57
+	Hs
		244438 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		MDC1_HUMAN (880-1548): 4.59e-20: 99.8: 10.03
+	Hs
		245142 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		NCOR2_HUMAN (339-1556): 7.75e-13: 76: 9.55
+	Hs
		1199206 PB1_HUMAN (26-956): 2.35e-19: 97.1: 10.81		BICRA_HUMAN (1-1560): 1.85e-111: 390: 100.00
+	Hs
		244321 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		IF4G1_HUMAN (440-918): 2.81e-10: 67.6: 17.13
+	Hs
		244918 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		SP130_HUMAN (782-1548): 3.26e-10: 67.4: 9.09
+	Hs
		245076 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		MYO15_HUMAN (648-1038): 3.87e-10: 67.2: 17.02
+	Hs
		631465 BRD2_HUMAN (3-737): 2.87e-55: 209: 46.43		BICRL_HUMAN (624-1248): 4.85e-35: 148: 24.32
+	Hs
		577643 BRD3_HUMAN (37-738): 5.99e-55: 207: 47.53		SON_HUMAN (60-1516): 8.3e-31: 135: 10.57
+	Hs
		631425 BRD2_HUMAN (3-737): 2.87e-55: 209: 46.43		MDC1_HUMAN (880-1548): 4.59e-20: 99.8: 10.03
+	Hs
		1056838 BRD3_HUMAN (37-738): 5.99e-55: 207: 47.53		MDC1_HUMAN (880-1548): 4.59e-20: 99.8: 10.03
+	Hs
		1067200 BRD3_HUMAN (37-738): 5.99e-55: 207: 47.53		SRRM2_HUMAN (28-1524): 1.56e-19: 98.3: 8.01
+	Hs
		319398 BRD1_HUMAN (197-781): 8.89e-33: 140: 13.99		NCOR2_HUMAN (339-1556): 7.75e-13: 76: 9.55
+	Dm
		532749 FSH_DROME (320-483): 8.28e-29: 128: 33.13		Q9VLS7_DROME (612-1030): 2.92e-09: 64.5: 18.87
+	Dm
		1370354 NU301_DROME (330-457): 2.51e-24: 113: 30.47		Q9VLS7_DROME (612-1030): 2.92e-09: 64.5: 18.87
+	Mm
		1207212 KMT2C_MOUSE (495-1183): 4.41e-22: 106: 13.55		NCOA6_MOUSE (714-1392): 4.94e-11: 70.2: 10.10
+	Hs
		311827 KAT2B_HUMAN (327-456): 5.61e-22: 105: 26.92		TACC2_HUMAN (839-1558): 4.86e-09: 63.7: 9.42
+	Hs
		311826 KAT2A_HUMAN (327-456): 1.76e-20: 100: 26.15		TACC2_HUMAN (839-1558): 4.86e-09: 63.7: 9.42