HitPredict

Interactor 1: GRK6 (O70293)
G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6)
Gene: GRK6

Interactor 2: OPSD (P15409)
Rhodopsin
Gene: Rho

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	10446210
Identification Methods	protein kinase assay
Interaction Type	phosphorylation reaction

Property	Details
Interacting Pfam domains	7tm_1~Pkinase
Common GO terms	GO:0016020 - membrane
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 576 Mm			1 348
+	Hs
		428959 GRK6_HUMAN (1-576): 0: 580: 96.70		ADRB2_HUMAN (1-338): 8.47e-71: 228: 17.58
+	Hs
		435865 GRK5_HUMAN (1-560): 1.43e-177: 516: 72.50		OPSD_HUMAN (1-348): 6.43e-79: 246: 94.83
+	Hs
		428938 GRK5_HUMAN (1-560): 1.43e-177: 516: 72.50		ADRB2_HUMAN (1-338): 8.47e-71: 228: 17.58
+	Hs
		626733 GRK5_HUMAN (1-560): 1.43e-177: 516: 72.50		NK1R_HUMAN (13-340): 9.8e-71: 227: 22.69
+	Hs
		428935 GRK4_HUMAN (1-575): 1.83e-176: 513: 64.99		ADRB2_HUMAN (1-338): 8.47e-71: 228: 17.58
+	Bt
		362127 GRK1_BOVIN (3-551): 5.37e-159: 467: 46.03		OPSD_BOVIN (1-348): 1.31e-85: 264: 93.39
+	Hs
		674828 GRK5_HUMAN (1-560): 1.43e-177: 516: 72.50		AGTR1_HUMAN (32-348): 6.67e-65: 211: 19.94
+	Hs
		435867 GRK1_HUMAN (3-537): 4.18e-156: 460: 47.59		OPSD_HUMAN (1-348): 6.43e-79: 246: 94.83
+	Hs
		429053 GRK1_HUMAN (3-537): 4.18e-156: 460: 47.59		ADRB2_HUMAN (1-338): 8.47e-71: 228: 17.58
+	Hs
		435861 ARBK1_HUMAN (2-518): 3.64e-144: 434: 37.69		OPSD_HUMAN (1-348): 6.43e-79: 246: 94.83
+	Hs
		428943 ARBK2_HUMAN (2-518): 4.3e-146: 439: 38.07		ADRB2_HUMAN (1-338): 8.47e-71: 228: 17.58
+	Hs
		428923 ARBK1_HUMAN (2-518): 3.64e-144: 434: 37.69		ADRB2_HUMAN (1-338): 8.47e-71: 228: 17.58
+	Hs
		626625 ARBK1_HUMAN (2-518): 3.64e-144: 434: 37.69		AGTR1_HUMAN (32-348): 6.67e-65: 211: 19.94
+	Hs
		626645 ARBK1_HUMAN (2-518): 3.64e-144: 434: 37.69		GPR17_HUMAN (34-325): 4.09e-18: 86.3: 23.26