HitPredict

Interactor 1: CSKP (O70589)
Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase)
Gene: Cask

Interactor 2: LIN7C (O88952)
Protein lin-7 homolog C (Lin-7C) (mLin7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3)
Gene: LIN7C

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.853

Property	Details
Experiments	9822620, 16186258, 19022416
Identification Methods	pull down, affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Guanylate_kin~PDZ, L27~L27, PDZ~PDZ, PDZ~SH3_2
Common GO terms	GO:0005911 - cell-cell junction GO:0016323 - basolateral plasma membrane GO:0030165 - PDZ domain binding GO:0045202 - synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 926 Mm			1 197
+	Hs
		159277 CSKP_HUMAN (1-926): 0: 967: 99.89		LIN7C_HUMAN (1-197): 1.38e-57: 181: 100.00
+	Hs
		159269 CSKP_HUMAN (1-926): 0: 967: 99.89		LIN7B_HUMAN (1-196): 4.81e-55: 175: 84.69
+	Mm
		251089 CSKP_MOUSE (1-926): 0: 967: 100.00		LIN7B_MOUSE (1-196): 4.08e-55: 175: 85.71
+	Hs
		158254 CSKP_HUMAN (1-926): 0: 967: 99.89		LIN7A_HUMAN (6-194): 4.87e-51: 166: 80.42
+	Hs
		159203 CSKP_HUMAN (1-926): 0: 967: 99.89		SNTB2_HUMAN (61-179): 3e-32: 123: 35.25
+	Hs
		159110 CSKP_HUMAN (1-926): 0: 967: 99.89		CSKP_HUMAN (13-194): 1.3e-30: 119: 20.53
+	Hs
		159207 CSKP_HUMAN (1-926): 0: 967: 99.89		SNTB1_HUMAN (65-179): 5.68e-31: 119: 35.90
+	Hs
		159190 CSKP_HUMAN (1-926): 0: 967: 99.89		DLG4_HUMAN (59-195): 2.19e-23: 98.7: 26.76
+	Hs
		159200 CSKP_HUMAN (1-926): 0: 967: 99.89		DLG1_HUMAN (50-178): 8.31e-23: 97.1: 30.60
+	Mm
		251104 CSKP_MOUSE (1-926): 0: 967: 100.00		DLG1_MOUSE (50-178): 1.33e-22: 96.3: 30.60
+	Hs
		159249 CSKP_HUMAN (1-926): 0: 967: 99.89		DLG3_HUMAN (74-164): 2.8e-20: 89.8: 35.42
+	Rn
		1144009 CSKP_RAT (1-926): 0: 940: 97.84		DLG1_RAT (94-178): 2.77e-21: 92.5: 37.78
+	Dm
		1096800 CSKP_DROME (1-926): 0: 831: 60.38		Q9VBY7_DROME (1-195): 1.45e-52: 168: 80.00
+	Ce
		873636 LIN2_CAEEL (2-926): 0: 738: 45.31		Q9U245_CAEEL (3-195): 2.33e-42: 142: 67.88
+	Dm
		116476 M9PJD0_DROME (287-926): 3.02e-154: 500: 24.89		Q9VBY7_DROME (1-195): 1.45e-52: 168: 80.00
+	Mm
		936188 DLG3_MOUSE (401-922): 6.89e-153: 473: 22.97		DLG2_MOUSE (23-196): 1.12e-25: 105: 23.63
+	Mm
		936180 DLG3_MOUSE (401-922): 6.89e-153: 473: 22.97		DLG4_MOUSE (59-195): 8.13e-24: 99.8: 26.76
+	Rn
		677790 DLG3_RAT (401-922): 6.6e-153: 473: 22.97		DLG4_RAT (59-195): 2.17e-23: 98.7: 26.76
+	Rn
		1144010 DLG3_RAT (401-922): 6.6e-153: 473: 22.97		DLG1_RAT (94-178): 2.77e-21: 92.5: 37.78
+	Dm
		53136 A1Z8G0_DROME (364-925): 1.66e-150: 459: 28.95		DLG1_DROME (57-176): 1.06e-14: 73.6: 28.00