Protein: MED27
Mediator of RNA polymerase II transcription subunit 27 (Cofactor required for Sp1 transcriptional activation subunit 8) (CRSP complex subunit 8) (Mediator complex subunit 27) (P37 TRAP/SMCC/PC2 subunit) (Transcriptional coactivator CRSP34)

Gene: MED27
Organism: Homo sapiens
Interactions: 105
UniProt ID: Q6P2C8

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005667 - transcription regulator complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1158924

MED20
Mediator of RNA polymerase II transcription subunit 20

5

1

Small-scale

0.930

High

826297

CDK8
Cyclin-dependent kinase 8

9

3

High-throughput

0.754

High

1158908

MED12
Mediator of RNA polymerase II transcription subunit 12

6

1

High-throughput

0.733

High

1158921

CDK19
Cyclin-dependent kinase 19

6

3

High-throughput

0.733

High

1158919

MED10
Mediator of RNA polymerase II transcription subunit 10

6

1

Small-scale

0.732

High

48686

MED19
Mediator of RNA polymerase II transcription subunit 19

9

0

Small-scale

0.722

High

206627

MED7
Mediator of RNA polymerase II transcription subunit 7

5

1

High-throughput

0.722

High

1158920

MED18
Mediator of RNA polymerase II transcription subunit 18

5

1

High-throughput

0.722

High

624448

CCNC
Cyclin-C

5

1

High-throughput

0.714

High

1076166

MED1
Mediator of RNA polymerase II transcription subunit 1

6

0

Small-scale

0.702

High

1158925

MED4
Mediator of RNA polymerase II transcription subunit 4

4

2

High-throughput

0.702

High

1158926

MED17
Mediator of RNA polymerase II transcription subunit 17

4

1

Small-scale

0.702

High

1158922

MED28
Mediator of RNA polymerase II transcription subunit 28

6

0

Small-scale

0.701

High

1158929

MED29
Mediator of RNA polymerase II transcription subunit 29

4

1

High-throughput

0.699

High

1158911

MED30
Mediator of RNA polymerase II transcription subunit 30

4

1

Small-scale

0.696

High

1074707

MED22
Mediator of RNA polymerase II transcription subunit 22

5

0

Small-scale

0.691

High

1037061

MED21
Mediator of RNA polymerase II transcription subunit 21

4

0

High-throughput

0.674

High

313440

MED26
Mediator of RNA polymerase II transcription subunit 26

4

0

High-throughput

0.670

High

270510

MED6
Mediator of RNA polymerase II transcription subunit 6

3

1

Small-scale

0.662

High

1158932

MED13
Mediator of RNA polymerase II transcription subunit 13

3

1

High-throughput

0.662

High

1158927

MED9
Mediator of RNA polymerase II transcription subunit 9

4

0

Small-scale

0.661

High

225389

MED14
Mediator of RNA polymerase II transcription subunit 14

3

2

Small-scale

0.656

High

1158910

MED8
Mediator of RNA polymerase II transcription subunit 8

3

1

Small-scale

0.656

High

1158933

MED23
Mediator of RNA polymerase II transcription subunit 23

3

2

High-throughput

0.656

High

1158897

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

3

1

High-throughput

0.650

High

369831

ESR1
Estrogen receptor

3

3

Small-scale

0.641

High

265335

MED24
Mediator of RNA polymerase II transcription subunit 24

3

0

High-throughput

0.638

High

583504

RPB3
DNA-directed RNA polymerase II subunit RPB3

3

0

Small-scale

0.638

High

1158914

MED15
Mediator of RNA polymerase II transcription subunit 15

2

1

High-throughput

0.611

High

1158930

MED11
Mediator of RNA polymerase II transcription subunit 11

2

1

High-throughput

0.611

High

181426

RPB4
DNA-directed RNA polymerase II subunit RPB4

2

0

High-throughput

0.602

High

583729

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

2

0

High-throughput

0.602

High

1158935

MED31
Mediator of RNA polymerase II transcription subunit 31

2

0

High-throughput

0.602

High

624933

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

0

High-throughput

0.585

High

676913

RPB2
DNA-directed RNA polymerase II subunit RPB2

2

0

High-throughput

0.585

High

897543

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

2

0

High-throughput

0.585

High

1158934

MED16
Mediator of RNA polymerase II transcription subunit 16

2

0

High-throughput

0.585

High

244578

BRD4
Bromodomain-containing protein 4

2

0

High-throughput

0.559

High

260912

H2AY
Core histone macro-H2A.1

1

4

High-throughput

0.536

High

470054

H2AZ
Histone H2A.Z

1

3

High-throughput

0.536

High

509030

TOP2A
DNA topoisomerase 2-alpha

1

1

High-throughput

0.536

High

973352

TOP2B
DNA topoisomerase 2-beta

1

1

High-throughput

0.536

High

1087200

H2B2E
Histone H2B type 2-E

1

1

High-throughput

0.536

High

1158900

H2A2B
Histone H2A type 2-B

1

2

High-throughput

0.536

High

1158902

H2B3B
Histone H2B type 3-B

1

1

High-throughput

0.536

High

1158917

H2A1J
Histone H2A type 1-J

1

2

High-throughput

0.536

High

1158918

H2AJ
Histone H2A.J

1

2

High-throughput

0.536

High

1158931

H2AW
Core histone macro-H2A.2

1

4

High-throughput

0.536

High

727761

SOX5
Transcription factor SOX-5

1

0

High-throughput

0.518

High

986926

SUH
Recombining binding protein suppressor of hairless

1

0

High-throughput

0.518

High

1158903

ARFG1
ADP-ribosylation factor GTPase-activating protein 1

1

0

High-throughput

0.518

High

426670

H10
Histone H1.0

1

0

High-throughput

0.513

High

868553

ATX1
Ataxin-1

1

0

High-throughput

0.513

High

1158895

FXL19
F-box/LRR-repeat protein 19

1

0

High-throughput

0.513

High

1158898

MED25
Mediator of RNA polymerase II transcription subunit 25

1

0

High-throughput

0.513

High

1158912

ZN512
Zinc finger protein 512

1

0

High-throughput

0.513

High

1158936

FBX7
F-box only protein 7

1

0

High-throughput

0.480

High

266371

TAD2A
Transcriptional adapter 2-alpha

1

2

High-throughput

0.479

High

318646

EYA4
Eyes absent homolog 4

1

1

High-throughput

0.479

High

487527

ANDR
Androgen receptor

1

3

High-throughput

0.479

High

1146515

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.479

High

1158899

MD12L
Mediator of RNA polymerase II transcription subunit 12-like protein

1

1

High-throughput

0.479

High

295535

RECQ5
ATP-dependent DNA helicase Q5

1

0

High-throughput

0.458

High

304631

SCAF4
SR-related and CTD-associated factor 4

1

0

High-throughput

0.458

High

347079

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

361580

APOA2
Apolipoprotein A-II

1

0

High-throughput

0.458

High

374400

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

386935

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

552974

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

651477

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

720720

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

738851

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

0

High-throughput

0.458

High

779607

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

808701

YAP1
Transcriptional coactivator YAP1

1

0

High-throughput

0.458

High

854316

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

High-throughput

0.458

High

854433

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

1

0

High-throughput

0.458

High

864953

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

High-throughput

0.458

High

913909

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

0

High-throughput

0.458

High

921128

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

0

High-throughput

0.458

High

961161

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

1014150

CPSF1
Cleavage and polyadenylation specificity factor subunit 1

1

0

High-throughput

0.458

High

1018992

TP53B
TP53-binding protein 1

1

0

High-throughput

0.458

High

1076246

TRIP4
Activating signal cointegrator 1

1

0

High-throughput

0.458

High

1132702

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

0

High-throughput

0.458

High

1137923

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

0

High-throughput

0.458

High

1158896

ACD11
Acyl-CoA dehydrogenase family member 11

1

0

High-throughput

0.458

High

1158901

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

1

0

High-throughput

0.458

High

1158904

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

High-throughput

0.458

High

1158905

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

0

Small-scale

0.458

High

1158909

FBXW7
F-box/WD repeat-containing protein 7

1

0

Small-scale

0.458

High

1158913

QKI
KH domain-containing RNA-binding protein QKI

1

0

High-throughput

0.458

High

1158916

EPAS1
Endothelial PAS domain-containing protein 1

1

0

Small-scale

0.458

High

1158923

STN1
CST complex subunit STN1

1

0

High-throughput

0.458

High

1158928

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

0

Small-scale

0.458

High

73030

B4DUB1
cDNA FLJ50029, highly similar to Cell division cycle 2-like protein kinase 6

1

3

High-throughput

0.445

High

91300

E5RFK5
Cyclin-C

1

1

High-throughput

0.445

High

1128608

Q5JWT2
Mediator of RNA polymerase II transcription subunit 23

1

2

High-throughput

0.445

High

1135250

Q5T911
Mediator of RNA polymerase II transcription subunit 4

1

2

High-throughput

0.445

High

1158907

ESR2
Estrogen receptor beta

1

3

High-throughput

0.445

High

1158915

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

831429

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.391

High

363976

FETA
Alpha-fetoprotein

1

0

High-throughput

0.282

High

1158906

ZCH10
Zinc finger CCHC domain-containing protein 10

1

0

High-throughput

0.279

Low

1150665

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

1

0

High-throughput

0.249

Low

473909

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024