HitPredict

Interactor 1: PRS6B (O74894)
26S proteasome regulatory subunit 6B homolog
Gene: rpt3

Interactor 2: RPN11 (P41878)
26S proteasome regulatory subunit rpn11 (Protein pad1)
Gene: RPN11

Species: Schizosaccharomyces pombe 972h-

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	24938783, 20838651, 22307589
Identification Methods	cross-linking study, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	JAB~Prot_ATP_ID_OB
Common GO terms	GO:0005737 - cytoplasm GO:0034399 - nuclear periphery GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 389 Sp			1 308
+	At
		1339598 PRS4A_ARATH (12-382): 7.08e-154: 442: 49.06		PSDE_ARATH (1-308): 1.67e-110: 324: 69.81
+	Dm
		820501 PRS4_DROME (12-382): 4.55e-152: 438: 46.38		PSDE_DROME (1-308): 7.51e-111: 325: 67.86
+	Hs
		130831 PRS4_HUMAN (12-382): 6.07e-134: 392: 47.45		PSDE_HUMAN (19-308): 2.23e-105: 311: 70.35
+	Dm
		1358669 Q9V405_DROME (1-389): 7.16e-126: 370: 74.29		PSDE_DROME (1-308): 7.51e-111: 325: 67.86
+	Dm
		186131 PRS8_DROME (11-389): 4.84e-123: 363: 39.58		PSDE_DROME (1-308): 7.51e-111: 325: 67.86
+	Dm
		1358678 Q9W414_DROME (9-389): 3.76e-121: 358: 40.68		PSDE_DROME (1-308): 7.51e-111: 325: 67.86
+	Hs
		130788 PRS6B_HUMAN (2-389): 5.31e-125: 368: 73.71		PSDE_HUMAN (19-308): 2.23e-105: 311: 70.35
+	Hs
		130835 PRS10_HUMAN (7-389): 1.07e-124: 366: 39.16		PSDE_HUMAN (19-308): 2.23e-105: 311: 70.35
+	Hs
		130832 PRS8_HUMAN (10-389): 2.1e-119: 354: 39.21		PSDE_HUMAN (19-308): 2.23e-105: 311: 70.35
+	Dm
		640769 PRS4_DROME (12-382): 4.55e-152: 438: 46.38		PSMD7_DROME (26-307): 6.44e-60: 196: 19.05
+	At
		1320084 PRS4A_ARATH (12-382): 7.08e-154: 442: 49.06		PSD7B_ARATH (15-307): 3.7e-57: 188: 18.09
+	At
		188943 PRS4A_ARATH (12-382): 7.08e-154: 442: 49.06		PSD7A_ARATH (15-307): 4.68e-57: 188: 17.76
+	Hs
		913330 PRS10_HUMAN (7-389): 1.07e-124: 366: 39.16		CSN5_HUMAN (28-304): 3.44e-73: 230: 30.10
+	Hs
		849176 PRS4_HUMAN (12-382): 6.07e-134: 392: 47.45		PSMD7_HUMAN (27-307): 4.23e-59: 193: 19.80
+	Dm
		640783 Q9V405_DROME (1-389): 7.16e-126: 370: 74.29		PSMD7_DROME (26-307): 6.44e-60: 196: 19.05
+	Hs
		798615 PRS6B_HUMAN (2-389): 5.31e-125: 368: 73.71		PSMD7_HUMAN (27-307): 4.23e-59: 193: 19.80
+	Dm
		186102 PRS8_DROME (11-389): 4.84e-123: 363: 39.58		PSMD7_DROME (26-307): 6.44e-60: 196: 19.05
+	Hs
		849179 PRS10_HUMAN (7-389): 1.07e-124: 366: 39.16		PSMD7_HUMAN (27-307): 4.23e-59: 193: 19.80
+	Dm
		640797 Q9W414_DROME (9-389): 3.76e-121: 358: 40.68		PSMD7_DROME (26-307): 6.44e-60: 196: 19.05
+	Hs
		849177 PRS8_HUMAN (10-389): 2.1e-119: 354: 39.21		PSMD7_HUMAN (27-307): 4.23e-59: 193: 19.80