HitPredict

Interactor 1: CAPON (O75052)
Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C-terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein)
Gene: NOS1AP

Interactor 2: LRP1 (Q07954)
Prolow-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD antigen CD91) [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit (LRP-85); Low-density lipoprotein receptor-related protein 1 515 kDa subunit (LRP-515); Low-density lipoprotein receptor-related protein 1 intracellular domain (LRPICD)]
Gene: LRP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.46	0.60	0.527

Property	Details
Experiments	10827173
Identification Methods	two hybrid, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 506 Hs			1 4544
+	Hs
		666087 SHC1_HUMAN (14-365): 2.59e-74: 247: 15.05		LRP1_HUMAN (24-4544): 0: 3520: 100.00
+	Hs
		992719 GULP1_HUMAN (8-306): 8.2e-67: 219: 19.14		LRP1_HUMAN (24-4544): 0: 3520: 100.00
+	Hs
		992682 ANS1B_HUMAN (3-223): 4.12e-50: 186: 23.11		LRP1_HUMAN (24-4544): 0: 3520: 100.00
+	Hs
		269141 DAB1_HUMAN (3-412): 9.18e-49: 179: 13.84		LRP1_HUMAN (24-4544): 0: 3520: 100.00
+	Hs
		253552 CAPON_HUMAN (1-506): 0: 552: 100.00		LRP2_HUMAN (4062-4370): 5.25e-10: 68.7: 11.50
+	Hs
		253558 CAPON_HUMAN (1-506): 0: 552: 100.00		LRP8_HUMAN (4104-4404): 8.77e-10: 67.6: 11.54
+	Mm
		966336 NUMB_MOUSE (3-415): 1.43e-76: 254: 17.13		NOTC1_MOUSE (3253-3657): 4.09e-10: 69.1: 11.79
+	Hs
		351135 SHC1_HUMAN (14-365): 2.59e-74: 247: 15.05		EGF_HUMAN (2718-2979): 3.56e-09: 65.6: 14.55
+	Dm
		422717 NUMB_DROME (3-401): 9.37e-64: 218: 19.16		NOTCH_DROME (2434-2789): 1.13e-10: 70.6: 11.72
+	Hs
		957612 ARH_HUMAN (2-284): 1.73e-66: 218: 24.09		LRP2_HUMAN (4062-4370): 5.25e-10: 68.7: 11.50
+	Hs
		351073 ARH_HUMAN (2-284): 1.73e-66: 218: 24.09		LDLR_HUMAN (4062-4338): 4.81e-10: 68.3: 11.95
+	Mm
		57558 ARH_MOUSE (2-282): 9.13e-65: 214: 24.00		LRP2_MOUSE (3242-3468): 6.42e-09: 64.9: 19.67
+	Rn
		88518 ARH_RAT (2-282): 1.88e-61: 205: 23.67		LRP2_RAT (4250-4538): 2.9e-10: 69.5: 14.33
+	Hs
		957621 ANS1B_HUMAN (3-223): 4.12e-50: 186: 23.11		LRP2_HUMAN (4062-4370): 5.25e-10: 68.7: 11.50
+	Hs
		269133 DAB1_HUMAN (3-412): 9.18e-49: 179: 13.84		VLDLR_HUMAN (27-282): 1.03e-11: 73.7: 18.49
+	Hs
		269134 DAB1_HUMAN (3-412): 9.18e-49: 179: 13.84		LRP2_HUMAN (4062-4370): 5.25e-10: 68.7: 11.50
+	Hs
		269114 DAB1_HUMAN (3-412): 9.18e-49: 179: 13.84		LDLR_HUMAN (4062-4338): 4.81e-10: 68.3: 11.95
+	Hs
		269145 DAB1_HUMAN (3-412): 9.18e-49: 179: 13.84		LRP8_HUMAN (4104-4404): 8.77e-10: 67.6: 11.54
+	Mm
		69879 DAB1_MOUSE (3-324): 5.24e-48: 176: 12.70		B1AXJ3_MOUSE (4296-4529): 1.43e-09: 66.8: 9.89
+	Mm
		57553 DAB1_MOUSE (3-324): 5.24e-48: 176: 12.70		LRP2_MOUSE (3242-3468): 6.42e-09: 64.9: 19.67