Protein: CLCN2
Chloride channel protein 2 (ClC-2)

Gene: CLCN2
Organism: Homo sapiens
Interactions: 52
UniProt ID: P51788

Gene Ontology (top 5):
GO:0005247 - voltage-gated chloride channel activity
GO:0005886 - plasma membrane
GO:0006821 - chloride transport
GO:0006911 - phagocytosis, engulfment
GO:0016323 - basolateral plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

378965

PIGR
Polymeric immunoglobulin receptor

1

0

High-throughput

0.656

High

907681

AQP3
Aquaporin-3

1

3

High-throughput

0.536

High

907698

UBQL1
Ubiquilin-1

1

0

High-throughput

0.518

High

474562

VIME
Vimentin

1

0

High-throughput

0.513

High

907694

MUC13
Mucin-13

1

0

High-throughput

0.513

High

907695

MUC5B
Mucin-5B

1

0

High-throughput

0.513

High

772689

MYH9
Myosin-9

1

0

High-throughput

0.493

High

907672

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

1

High-throughput

0.489

High

907687

SEC62
Translocation protein SEC62

1

1

High-throughput

0.489

High

907700

KLDC2
Kelch domain-containing protein 2

1

2

High-throughput

0.489

High

907666

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

0

Small-scale

0.486

High

373848

RASN
GTPase NRas

1

5

High-throughput

0.479

High

907671

FHL3
Four and a half LIM domains protein 3

1

1

High-throughput

0.439

High

226734

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

2

High-throughput

0.437

High

253555

PEX10
Peroxisome biogenesis factor 10

1

1

High-throughput

0.437

High

907669

CUL4A
Cullin-4A

1

5

Small-scale

0.437

High

907670

CUL4B
Cullin-4B

1

5

Small-scale

0.437

High

907673

DDB1
DNA damage-binding protein 1

1

2

Small-scale

0.437

High

907683

Q96BE0
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.437

High

907686

CRBN
Protein cereblon

1

3

Small-scale

0.437

High

907699

CHIP
E3 ubiquitin-protein ligase CHIP

1

1

High-throughput

0.437

High

379627

IGHA1
Immunoglobulin heavy constant alpha 1

1

0

High-throughput

0.426

High

94364

D6RA89
RING-type E3 ubiquitin transferase

1

1

High-throughput

0.407

High

907663

ATX1
Ataxin-1

1

0

High-throughput

0.282

High

188457

NVL
Nuclear valosin-containing protein-like

1

0

High-throughput

0.279

Low

378673

IGJ
Immunoglobulin J chain

1

0

High-throughput

0.279

Low

425716

PERM
Myeloperoxidase

1

0

High-throughput

0.279

Low

788606

SRP14
Signal recognition particle 14 kDa protein

1

0

High-throughput

0.279

Low

907665

LYSC
Lysozyme C

1

0

High-throughput

0.279

Low

907675

RFIP2
Rab11 family-interacting protein 2

1

0

High-throughput

0.279

Low

907677

CA052
UPF0690 protein C1orf52

1

0

High-throughput

0.279

Low

907678

SNIP1
Smad nuclear-interacting protein 1

1

0

High-throughput

0.279

Low

907679

ZCH10
Zinc finger CCHC domain-containing protein 10

1

0

High-throughput

0.279

Low

907680

BPIB1
BPI fold-containing family B member 1

1

0

High-throughput

0.279

Low

907682

GPKOW
G-patch domain and KOW motifs-containing protein

1

0

High-throughput

0.279

Low

907684

TOE1
Target of EGR1 protein 1

1

0

High-throughput

0.279

Low

907685

ZN668
Zinc finger protein 668

1

0

High-throughput

0.279

Low

907688

SRSF8
Serine/arginine-rich splicing factor 8

1

0

High-throughput

0.279

Low

907690

YJU2
Splicing factor YJU2

1

0

High-throughput

0.279

Low

907691

PIP30
PSME3-interacting protein

1

0

High-throughput

0.279

Low

907692

LACRT
Extracellular glycoprotein lacritin

1

0

High-throughput

0.279

Low

907693

TDIF1
Deoxynucleotidyltransferase terminal-interacting protein 1

1

0

High-throughput

0.279

Low

907696

SH22A
SH2 domain-containing protein 2A

1

0

High-throughput

0.279

Low

907697

DMBT1
Scavenger receptor cysteine-rich domain-containing protein DMBT1

1

0

High-throughput

0.279

Low

76512

B4DYC6
cDNA FLJ60958, highly similar to Homo sapiens SGT1, suppressor of G2 allele of SKP1

1

0

High-throughput

0.249

Low

346910

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.249

Low

907664

MLF1
Myeloid leukemia factor 1

1

0

High-throughput

0.249

Low

907667

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

1

0

High-throughput

0.249

Low

907668

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

0

High-throughput

0.249

Low

907674

Q53FC7
Heat shock 70 kDa protein 6

1

0

High-throughput

0.249

Low

907676

NUDC3
NudC domain-containing protein 3

1

0

High-throughput

0.249

Low

907689

AASD1
Alanyl-tRNA editing protein Aarsd1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025