HitPredict

Interactor 1: PHF2 (O75151)
Lysine-specific demethylase PHF2 (EC 1.14.11.-) (GRC5) (PHD finger protein 2)
Gene: PHF2

Interactor 2: HNF4A (P41235)
Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4)
Gene: HNF4A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	21532585
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0008270 - zinc ion binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1096 Hs			1 474
+	Hs
		782597 KDM2B_HUMAN (39-1055): 0: 735: 19.32		HNF4A_HUMAN (1-474): 0: 542: 100.00
+	Hs
		256376 PHF2_HUMAN (1-1096): 0: 919: 100.00		ESR1_HUMAN (10-432): 3.46e-112: 345: 21.37
+	Hs
		488036 PHF8_HUMAN (1-1096): 0: 903: 47.35		RARA_HUMAN (9-382): 7.34e-107: 327: 25.06
+	Hs
		256425 PHF2_HUMAN (1-1096): 0: 919: 100.00		ESR2_HUMAN (44-374): 2.23e-99: 310: 27.64
+	Hs
		1069094 PHF8_HUMAN (1-1096): 0: 903: 47.35		Q15156_HUMAN (30-382): 3.17e-98: 314: 26.50
+	Hs
		1269941 PHF8_HUMAN (1-1096): 0: 903: 47.35		ESR2_HUMAN (44-374): 2.23e-99: 310: 27.64
+	Hs
		370049 KDM2B_HUMAN (39-1055): 0: 735: 19.32		ESR1_HUMAN (10-432): 3.46e-112: 345: 21.37
+	Hs
		1245580 KDM2B_HUMAN (39-1055): 0: 735: 19.32		ESR2_HUMAN (44-374): 2.23e-99: 310: 27.64
+	Hs
		370756 KDM2A_HUMAN (54-926): 0: 651: 19.24		ESR1_HUMAN (10-432): 3.46e-112: 345: 21.37
+	Hs
		1269974 KDM2A_HUMAN (54-926): 0: 651: 19.24		ESR2_HUMAN (44-374): 2.23e-99: 310: 27.64
+	Hs
		510029 KDM2B_HUMAN (39-1055): 0: 735: 19.32		ERR1_HUMAN (59-374): 7.31e-38: 144: 28.90
+	Hs
		782675 CXXC1_HUMAN (5-126): 2.47e-26: 117: 31.15		HNF4A_HUMAN (1-474): 0: 542: 100.00
+	Hs
		782532 BPTF_HUMAN (6-61): 1.51e-18: 94.2: 48.21		HNF4A_HUMAN (1-474): 0: 542: 100.00
+	Hs
		369607 MDC1_HUMAN (425-1089): 6.63e-30: 131: 12.88		ESR1_HUMAN (10-432): 3.46e-112: 345: 21.37
+	Hs
		370329 DIDO1_HUMAN (5-92): 3.08e-20: 99.7: 30.44		ESR1_HUMAN (10-432): 3.46e-112: 345: 21.37
+	Hs
		1056909 MDC1_HUMAN (425-1089): 6.63e-30: 131: 12.88		ESR2_HUMAN (44-374): 2.23e-99: 310: 27.64
+	Hs
		1017331 BPTF_HUMAN (6-61): 1.51e-18: 94.2: 48.21		ESR2_HUMAN (44-374): 2.23e-99: 310: 27.64
+	Mm
		93662 E9Q6A7_MOUSE (6-61): 2.7e-18: 93.5: 48.21		ERR2_MOUSE (9-375): 1.5e-99: 307: 27.37
+	Ce
		136799 UNC89_CAEEL (390-1072): 2.94e-49: 194: 9.75		NHR1_CAEEL (35-375): 5.7e-40: 151: 29.11