HitPredict

Interactor 1: BRE1B (O75150)
E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B)
Gene: RNF40

Interactor 2: H2B2E (Q16778)
Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q)
Gene: H2BC21

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.651

Property	Details
Experiments	29507117, 16307923, 24837678
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1001 Hs			1 126
+	Hs
		256219 BRE1B_HUMAN (1-1001): 5.92e-75: 268: 100.00		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Hs
		1087184 BRE1A_HUMAN (1-1000): 8.12e-65: 238: 56.49		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		707654 BRE1A_HUMAN (1-1000): 8.12e-65: 238: 56.49		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Mm
		1125390 BRE1A_MOUSE (1-1000): 4.02e-64: 236: 56.59		H2B1B_MOUSE (1-126): 4.91e-52: 162: 96.03
+	Sc
		356028 BRE1_YEAST (506-1000): 2.2e-57: 212: 18.77		H2B2_YEAST (3-125): 4.73e-37: 124: 71.55
+	Sc
		355667 BRE1_YEAST (506-1000): 2.2e-57: 212: 18.77		H2B1_YEAST (3-125): 1.81e-36: 122: 71.55
+	Hs
		1274476 MYH2_HUMAN (291-983): 3.18e-32: 138: 9.47		H2B1H_HUMAN (1-126): 6.27e-54: 166: 98.41
+	Hs
		724751 MYH9_HUMAN (271-982): 5.38e-32: 137: 10.53		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		724951 MYH9_HUMAN (271-982): 5.38e-32: 137: 10.53		H2B1H_HUMAN (1-126): 6.27e-54: 166: 98.41
+	Hs
		241463 MYH9_HUMAN (271-982): 5.38e-32: 137: 10.53		H2B1K_HUMAN (1-126): 1.56e-53: 165: 98.41
+	Hs
		724734 MYH9_HUMAN (271-982): 5.38e-32: 137: 10.53		H2B1D_HUMAN (1-126): 3.5e-53: 164: 98.41
+	Hs
		725133 MYH10_HUMAN (1-443): 3.14e-19: 96.3: 12.58		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		725214 MYH10_HUMAN (1-443): 3.14e-19: 96.3: 12.58		H2B1H_HUMAN (1-126): 6.27e-54: 166: 98.41
+	Hs
		241464 MYH10_HUMAN (1-443): 3.14e-19: 96.3: 12.58		H2B1K_HUMAN (1-126): 1.56e-53: 165: 98.41
+	Hs
		433154 LAMB1_HUMAN (82-412): 8.06e-19: 94.7: 12.65		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		725122 MYH10_HUMAN (1-443): 3.14e-19: 96.3: 12.58		H2B1D_HUMAN (1-126): 3.5e-53: 164: 98.41
+	Hs
		728463 MYH11_HUMAN (563-983): 2.12e-18: 93.6: 10.66		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		241465 MYH11_HUMAN (563-983): 2.12e-18: 93.6: 10.66		H2B1K_HUMAN (1-126): 1.56e-53: 165: 98.41
+	Hs
		725231 MYH10_HUMAN (1-443): 3.14e-19: 96.3: 12.58		H2B1L_HUMAN (1-126): 2.49e-52: 162: 97.62
+	Hs
		148194 CTRO_HUMAN (248-944): 2.51e-10: 67.2: 14.91		H2B1K_HUMAN (1-126): 1.56e-53: 165: 98.41