HitPredict

Interactor 1: SIN3B (O75182)
Paired amphipathic helix protein Sin3b (Histone deacetylase complex subunit Sin3b) (Transcriptional corepressor Sin3b)
Gene: SIN3B

Interactor 2: ING1 (Q9UK53)
Inhibitor of growth protein 1
Gene: ING1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0030336 - negative regulation of cell migration
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 1162 Hs			1 422
+	Hs
		257831 SIN3B_HUMAN (1-1162): 0: 1453: 100.00		ING2_HUMAN (158-419): 3.18e-61: 201: 51.91
+	Hs
		257773 SIN3B_HUMAN (1-1162): 0: 1453: 100.00		BPTF_HUMAN (162-401): 2.27e-37: 147: 18.40
+	Hs
		257774 SIN3B_HUMAN (1-1162): 0: 1453: 100.00		CHD3_HUMAN (246-406): 1.87e-24: 108: 18.79
+	Hs
		257809 SIN3B_HUMAN (1-1162): 0: 1453: 100.00		CHD5_HUMAN (246-402): 3.06e-13: 74.1: 20.63
+	Hs
		1302472 SIN3A_HUMAN (78-366): 2.42e-15: 83.4: 15.60		ING1_HUMAN (1-422): 0: 572: 100.00
+	Hs
		1302441 SIN3A_HUMAN (78-366): 2.42e-15: 83.4: 15.60		ING2_HUMAN (158-419): 3.18e-61: 201: 51.91
+	Sc
		609114 SIN3_YEAST (38-241): 6.57e-30: 131: 28.08		PHO23_YEAST (212-402): 9.39e-33: 127: 24.75
+	Dm
		1137169 Q5U0Y0_DROME (113-262): 1.27e-22: 107: 36.31		Q9VEF5_DROME (272-422): 3.99e-32: 128: 39.07
+	Hs
		1017340 SIN3A_HUMAN (78-366): 2.42e-15: 83.4: 15.60		BPTF_HUMAN (162-401): 2.27e-37: 147: 18.40
+	Hs
		1018652 SIN3A_HUMAN (78-366): 2.42e-15: 83.4: 15.60		CHD3_HUMAN (246-406): 1.87e-24: 108: 18.79
+	Hs
		1059812 SIN3A_HUMAN (78-366): 2.42e-15: 83.4: 15.60		CHD4_HUMAN (246-417): 2.51e-21: 99.2: 19.89