HitPredict

Interactor 1: VATG1 (O75348)
V-type proton ATPase subunit G 1 (V-ATPase subunit G 1) (V-ATPase 13 kDa subunit 1) (Vacuolar proton pump subunit G 1) (Vacuolar proton pump subunit M16)
Gene: ATP6V1G1

Interactor 2: VATE2 (Q96A05)
V-type proton ATPase subunit E 2 (V-ATPase subunit E 2) (Vacuolar proton pump subunit E 2)
Gene: ATP6V1E2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.90	1.00	0.952

Property	Details
Experiments	21516116, 25416956, 32296183, 30021884, 33961781, unassigned1304
Identification Methods	two hybrid, proximity labelling technology, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid, cross-linking study
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	V-ATPase_G~vATP-synt_E
Common GO terms	GO:0005829 - cytosol GO:0016241 - regulation of macroautophagy GO:0046961 - proton-transporting ATPase activity, rotational mechanism
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 118 Hs			1 226
+	Hs
		260063 VATG1_HUMAN (1-118): 6.06e-32: 110: 100.00		VATE1_HUMAN (1-225): 3.66e-98: 286: 76.89
+	Hs
		318278 VATG2_HUMAN (1-118): 4.57e-27: 98.2: 63.56		VATE1_HUMAN (1-225): 3.66e-98: 286: 76.89
+	Dm
		870988 VATG_DROME (1-114): 1.86e-28: 101: 50.00		VATE_DROME (1-224): 4.6e-94: 276: 61.16
+	Ce
		954341 VATG_CAEEL (1-113): 3.5e-25: 93.6: 53.10		VATE_CAEEL (1-225): 1.25e-96: 282: 56.00
+	Hs
		318297 VATG2_HUMAN (1-118): 4.57e-27: 98.2: 63.56		VATE2_HUMAN (1-226): 5.41e-90: 266: 100.00
+	Zm
		76254 B4FMV3_MAIZE (4-107): 6.09e-20: 79.7: 40.39		B4FVD5_MAIZE (3-220): 2.64e-92: 272: 40.61
+	Sc
		605453 VATG_YEAST (3-113): 1.54e-21: 84: 37.84		VATE_YEAST (2-225): 2.38e-76: 231: 35.40