Protein: PHIP
PH-interacting protein (PHIP) (DDB1- and CUL4-associated factor 14) (IRS-1 PH domain-binding protein) (WD repeat-containing protein 11)

Gene: PHIP
Organism: Homo sapiens
Interactions: 196
UniProt ID: Q8WWQ0

Gene Ontology (top 5):
GO:0001932 - regulation of protein phosphorylation
GO:0005158 - insulin receptor binding
GO:0005634 - nucleus
GO:0006357 - regulation of transcription by RNA polymerase II
GO:0007010 - cytoskeleton organization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1157831

DDB1
DNA damage-binding protein 1

10

20

Small-scale

0.967

High

998599

H31
Histone H3.1

4

20

Small-scale

0.873

High

1017060

H33
Histone H3.3

3

20

Small-scale

0.827

High

1163092

H2B2E
Histone H2B type 2-E

2

17

Small-scale

0.789

High

1114960

CUL4A
Cullin-4A

11

20

Small-scale

0.755

High

1115322

CUL4B
Cullin-4B

8

20

Small-scale

0.750

High

883631

CENPA
Histone H3-like centromeric protein A

2

20

Small-scale

0.737

High

1104321

ORC1
Origin recognition complex subunit 1

1

2

High-throughput

0.691

High

224331

BUB3
Mitotic checkpoint protein BUB3

2

19

Small-scale

0.675

High

1141235

BRD3
Bromodomain-containing protein 3

1

20

High-throughput

0.665

High

822784

VHL
von Hippel-Lindau disease tumor suppressor

1

1

High-throughput

0.665

High

320739

UBXN7
UBX domain-containing protein 7

3

4

Small-scale

0.640

High

160116

CHD1
Chromodomain-helicase-DNA-binding protein 1

1

20

Small-scale

0.618

High

174572

TRI66
Tripartite motif-containing protein 66

1

20

High-throughput

0.618

High

243687

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

20

Small-scale

0.618

High

260219

BRD4
Bromodomain-containing protein 4

1

20

High-throughput

0.618

High

502073

H2AZ
Histone H2A.Z

1

17

Small-scale

0.618

High

639789

TAF1
Transcription initiation factor TFIID subunit 1

1

20

High-throughput

0.618

High

674266

BRD2
Bromodomain-containing protein 2

1

20

High-throughput

0.618

High

892055

TAF6
Transcription initiation factor TFIID subunit 6

1

5

High-throughput

0.618

High

903433

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

20

Small-scale

0.618

High

980051

H4
Histone H4

1

14

Small-scale

0.618

High

980959

H2B1C
Histone H2B type 1-C/E/F/G/I

1

17

High-throughput

0.618

High

1132858

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

20

Small-scale

0.618

High

1149783

TAF5
Transcription initiation factor TFIID subunit 5

1

17

High-throughput

0.618

High

1155592

EZH2
Histone-lysine N-methyltransferase EZH2

1

20

High-throughput

0.618

High

1162848

H2A2C
Histone H2A type 2-C

1

13

Small-scale

0.618

High

1202213

DCAF6
DDB1- and CUL4-associated factor 6

1

19

High-throughput

0.618

High

1218888

TAF3
Transcription initiation factor TFIID subunit 3

1

20

High-throughput

0.618

High

1247322

BRWD3
Bromodomain and WD repeat-containing protein 3

1

16

High-throughput

0.618

High

1258891

H32
Histone H3.2

1

20

Small-scale

0.618

High

1287961

PB1
Protein polybromo-1

1

20

Small-scale

0.618

High

1351274

CHD5
Chromodomain-helicase-DNA-binding protein 5

1

20

Small-scale

0.618

High

1359680

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

20

Small-scale

0.618

High

1359686

RSF1
Remodeling and spacing factor 1

1

20

Small-scale

0.618

High

1359693

MEP50
Methylosome protein WDR77

1

17

Small-scale

0.618

High

1359695

CECR2
Chromatin remodeling regulator CECR2

1

17

High-throughput

0.618

High

1359703

WDR76
WD repeat-containing protein 76

1

18

High-throughput

0.618

High

1065321

SSRP1
FACT complex subunit SSRP1

2

20

Small-scale

0.611

High

1134660

NUMA1
Nuclear mitotic apparatus protein 1

2

18

Small-scale

0.611

High

1161573

IF16
Gamma-interferon-inducible protein 16

2

8

High-throughput

0.611

High

559433

XRCC5
X-ray repair cross-complementing protein 5

2

2

Small-scale

0.584

High

1359733

SP16H
FACT complex subunit SPT16

2

8

Small-scale

0.584

High

157670

CTRO
Citron Rho-interacting kinase

1

12

High-throughput

0.553

High

1254828

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.553

High

1338866

NUP43
Nucleoporin Nup43

1

18

High-throughput

0.553

High

1359702

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.553

High

1359707

ANLN
Anillin

1

6

High-throughput

0.553

High

594059

NCK1
SH2/SH3 adapter protein NCK1

1

8

High-throughput

0.536

High

601781

HMGA1
High mobility group protein HMG-I/HMG-Y

1

2

High-throughput

0.536

High

613111

EGR1
Early growth response protein 1

1

1

High-throughput

0.536

High

693868

RL10
Large ribosomal subunit protein uL16

1

3

High-throughput

0.536

High

837750

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

3

High-throughput

0.536

High

1013087

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

4

High-throughput

0.536

High

1235479

IFIX
Pyrin and HIN domain-containing protein 1

1

8

High-throughput

0.536

High

1359684

HDA11
Histone deacetylase 11

1

20

High-throughput

0.536

High

1359685

DCNL1
DCN1-like protein 1

1

1

High-throughput

0.536

High

1359689

MPP8
M-phase phosphoprotein 8

1

15

High-throughput

0.536

High

1359692

VRK1
Serine/threonine-protein kinase VRK1

1

8

High-throughput

0.536

High

1359699

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

1

2

High-throughput

0.536

High

653467

HEMH
Ferrochelatase, mitochondrial

2

1

High-throughput

0.521

High

74560

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

16

High-throughput

0.515

High

386030

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

10

High-throughput

0.515

High

535343

BIP
Endoplasmic reticulum chaperone BiP

1

12

High-throughput

0.515

High

552849

TPR
Nucleoprotein TPR

1

20

High-throughput

0.515

High

1108635

TBB3
Tubulin beta-3 chain

1

20

High-throughput

0.481

High

130779

TAF4
Transcription initiation factor TFIID subunit 4

1

14

High-throughput

0.479

High

174376

ZN609
Zinc finger protein 609

1

12

High-throughput

0.479

High

177471

ZN536
Zinc finger protein 536

1

2

High-throughput

0.479

High

183041

NKRF
NF-kappa-B-repressing factor

1

3

High-throughput

0.479

High

190080

FOXP2
Forkhead box protein P2

1

20

High-throughput

0.479

High

223215

PRC1
Protein regulator of cytokinesis 1

1

15

High-throughput

0.479

High

245504

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

3

High-throughput

0.479

High

245727

GANP
Germinal-center associated nuclear protein

1

11

High-throughput

0.479

High

248327

HBP1
HMG box-containing protein 1

1

20

High-throughput

0.479

High

252470

DIAP1
Protein diaphanous homolog 1

1

2

High-throughput

0.479

High

272347

OBSL1
Obscurin-like protein 1

1

11

High-throughput

0.479

High

274205

ANR17
Ankyrin repeat domain-containing protein 17

1

6

High-throughput

0.479

High

318833

RHBT1
Rho-related BTB domain-containing protein 1

1

18

High-throughput

0.479

High

336228

ZIC2
Zinc finger protein ZIC 2

1

2

High-throughput

0.479

High

372693

MYC
Myc proto-oncogene protein

1

20

High-throughput

0.479

High

463681

LYN
Tyrosine-protein kinase Lyn

1

4

High-throughput

0.479

High

487576

PARP1
Poly [ADP-ribose] polymerase 1

1

12

High-throughput

0.479

High

517548

GLI3
Transcriptional activator GLI3

1

2

High-throughput

0.479

High

589266

RFA2
Replication protein A 32 kDa subunit

1

6

High-throughput

0.479

High

643956

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

7

High-throughput

0.479

High

652546

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

20

High-throughput

0.479

High

667947

CDK2
Cyclin-dependent kinase 2

1

7

Small-scale

0.479

High

696052

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.479

High

714299

PML
Protein PML

1

20

High-throughput

0.479

High

791580

SYUA
Alpha-synuclein

1

5

High-throughput

0.479

High

879305

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

16

High-throughput

0.479

High

905632

IRAK1
Interleukin-1 receptor-associated kinase 1

1

1

High-throughput

0.479

High

942778

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

14

High-throughput

0.479

High

958680

CSN2
COP9 signalosome complex subunit 2

1

5

Small-scale

0.479

High

965794

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

16

Small-scale

0.479

High

974430

SMD1
Small nuclear ribonucleoprotein Sm D1

1

16

Small-scale

0.479

High

979093

RS6
Small ribosomal subunit protein eS6

1

4

High-throughput

0.479

High

1035810

KIF23
Kinesin-like protein KIF23

1

13

High-throughput

0.479

High

1040341

DYST
Dystonin

1

18

High-throughput

0.479

High

1040862

MECOM
Histone-lysine N-methyltransferase MECOM

1

5

High-throughput

0.479

High

1094385

CSN1
COP9 signalosome complex subunit 1

1

5

Small-scale

0.479

High

1097450

CBX3
Chromobox protein homolog 3

1

11

High-throughput

0.479

High

1107057

BIRC3
Baculoviral IAP repeat-containing protein 3

1

10

High-throughput

0.479

High

1113841

CUL3
Cullin-3

1

20

Small-scale

0.479

High

1140619

KIF14
Kinesin-like protein KIF14

1

14

High-throughput

0.479

High

1154879

NEDD8
Ubiquitin-like protein NEDD8

1

6

Small-scale

0.479

High

1155980

ZFHX3
Zinc finger homeobox protein 3

1

7

High-throughput

0.479

High

1165479

CPEB4
Cytoplasmic polyadenylation element-binding protein 4

1

6

High-throughput

0.479

High

1241277

TAF2
Transcription initiation factor TFIID subunit 2

1

4

High-throughput

0.479

High

1246895

RICTR
Rapamycin-insensitive companion of mTOR

1

5

High-throughput

0.479

High

1250626

BCOR
BCL-6 corepressor

1

15

High-throughput

0.479

High

1257796

ACD11
Acyl-CoA dehydrogenase family member 11

1

1

High-throughput

0.479

High

1272498

CSN6
COP9 signalosome complex subunit 6

1

2

Small-scale

0.479

High

1281569

SLN11
Schlafen family member 11

1

2

High-throughput

0.479

High

1288838

ZFHX4
Zinc finger homeobox protein 4

1

4

High-throughput

0.479

High

1308707

FOXP4
Forkhead box protein P4

1

20

High-throughput

0.479

High

1310712

PHF6
PHD finger protein 6

1

20

Small-scale

0.479

High

1313292

SMC5
Structural maintenance of chromosomes protein 5

1

3

High-throughput

0.479

High

1316421

XRN1
5'-3' exoribonuclease 1

1

4

High-throughput

0.479

High

1359678

CSN5
COP9 signalosome complex subunit 5

1

7

Small-scale

0.479

High

1359682

DCPS
m7GpppX diphosphatase

1

1

High-throughput

0.479

High

1359687

HTF4
Transcription factor 12

1

1

High-throughput

0.479

High

1359688

RING2
E3 ubiquitin-protein ligase RING2

1

20

High-throughput

0.479

High

1359691

PKP2
Plakophilin-2

1

16

High-throughput

0.479

High

1359694

CSN4
COP9 signalosome complex subunit 4

1

1

Small-scale

0.479

High

1359696

RHBT2
Rho-related BTB domain-containing protein 2

1

18

High-throughput

0.479

High

1359697

BC11B
B-cell lymphoma/leukemia 11B

1

1

High-throughput

0.479

High

1359700

FOXP1
Forkhead box protein P1

1

16

High-throughput

0.479

High

1359704

AGO3
Protein argonaute-3

1

1

High-throughput

0.479

High

1359705

CSN7B
COP9 signalosome complex subunit 7b

1

2

Small-scale

0.479

High

1359706

PRD16
Histone-lysine N-methyltransferase PRDM16

1

5

High-throughput

0.479

High

1359708

4ET
Eukaryotic translation initiation factor 4E transporter

1

1

High-throughput

0.479

High

1359709

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

7

High-throughput

0.479

High

1359710

F120C
Constitutive coactivator of PPAR-gamma-like protein 2

1

3

High-throughput

0.479

High

1359711

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

1

3

High-throughput

0.479

High

1359712

RCOR3
REST corepressor 3

1

18

High-throughput

0.479

High

1359713

MYEF2
Myelin expression factor 2

1

5

High-throughput

0.479

High

1359714

RERE
Arginine-glutamic acid dipeptide repeats protein

1

14

High-throughput

0.479

High

1359715

HDAC6
Protein deacetylase HDAC6

1

20

High-throughput

0.479

High

1359716

CSN7A
COP9 signalosome complex subunit 7a

1

2

Small-scale

0.479

High

1359718

TBK1
Serine/threonine-protein kinase TBK1

1

9

High-throughput

0.479

High

1359719

TRPS1
Zinc finger transcription factor Trps1

1

17

High-throughput

0.479

High

1359720

RCOR1
REST corepressor 1

1

19

High-throughput

0.479

High

1359721

AGO2
Protein argonaute-2

1

1

High-throughput

0.479

High

1359723

INT6
Integrator complex subunit 6

1

2

High-throughput

0.479

High

1359724

ZN608
Zinc finger protein 608

1

8

High-throughput

0.479

High

1359725

CIZ1
Cip1-interacting zinc finger protein

1

7

High-throughput

0.479

High

1359726

AKP8L
A-kinase anchor protein 8-like

1

3

High-throughput

0.479

High

1359727

CSN3
COP9 signalosome complex subunit 3

1

5

Small-scale

0.479

High

1359730

SRRM2
Serine/arginine repetitive matrix protein 2

1

20

High-throughput

0.479

High

1359731

ZN281
Zinc finger protein 281

1

2

High-throughput

0.479

High

1359732

ZN330
Zinc finger protein 330

1

1

High-throughput

0.479

High

1359734

NCOR2
Nuclear receptor corepressor 2

1

20

High-throughput

0.479

High

1359735

IF2B2
Insulin-like growth factor 2 mRNA-binding protein 2

1

15

High-throughput

0.479

High

533724

CLUS
Clusterin

1

0

High-throughput

0.458

High

1359675

CSN9
COP9 signalosome complex subunit 9

1

0

Small-scale

0.458

High

1359676

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

0

High-throughput

0.458

High

1359690

CSN8
COP9 signalosome complex subunit 8

1

0

Small-scale

0.458

High

1359729

SATB2
DNA-binding protein SATB2

1

0

Small-scale

0.458

High

408116

TBB4A
Tubulin beta-4A chain

1

20

High-throughput

0.457

High

191019

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

5

High-throughput

0.437

High

220510

RNF13
E3 ubiquitin-protein ligase RNF13

1

3

High-throughput

0.437

High

346117

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

14

High-throughput

0.437

High

425936

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

16

High-throughput

0.437

High

539373

ODB2
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

1

5

High-throughput

0.437

High

613415

VINC
Vinculin

1

3

Small-scale

0.437

High

768752

RFA3
Replication protein A 14 kDa subunit

1

6

High-throughput

0.437

High

1028829

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

11

Small-scale

0.437

High

1130646

GSE1
Genetic suppressor element 1

1

1

High-throughput

0.437

High

1134496

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

12

Small-scale

0.437

High

1135007

CUL7
Cullin-7

1

7

High-throughput

0.437

High

1200204

SWAHC
Ankyrin repeat domain-containing protein SOWAHC

1

6

High-throughput

0.437

High

1210928

CE170
Centrosomal protein of 170 kDa

1

19

High-throughput

0.437

High

1215410

TUT4
Terminal uridylyltransferase 4

1

6

High-throughput

0.437

High

1311352

ANKH1
Ankyrin repeat and KH domain-containing protein 1

1

5

High-throughput

0.437

High

1322764

CNTRB
Centrobin

1

13

High-throughput

0.437

High

1328880

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

4

High-throughput

0.437

High

1336800

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

14

High-throughput

0.437

High

1359677

LAR4B
La-related protein 4B

1

7

High-throughput

0.437

High

1359679

GCDH
Glutaryl-CoA dehydrogenase, mitochondrial

1

1

High-throughput

0.437

High

1359681

CHCH1
Small ribosomal subunit protein mS37

1

1

High-throughput

0.437

High

1359683

CHM4C
Charged multivesicular body protein 4c

1

7

High-throughput

0.437

High

1359717

MKRN1
E3 ubiquitin-protein ligase makorin-1

1

3

High-throughput

0.437

High

1359722

NUP50
Nuclear pore complex protein Nup50

1

6

High-throughput

0.437

High

1359728

TNR6B
Trinucleotide repeat-containing gene 6B protein

1

8

High-throughput

0.437

High

391386

FRIL
Ferritin light chain

1

6

High-throughput

0.407

High

1119222

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

1

High-throughput

0.407

High

1359701

TXNIP
Thioredoxin-interacting protein

1

3

High-throughput

0.407

High

1359698

STMN4
Stathmin-4

1

0

High-throughput

0.282

High

1335265

NECP1
Adaptin ear-binding coat-associated protein 1

1

0

High-throughput

0.279

Low

176525

GRRE1
Granule associated Rac and RHOG effector protein 1

1

0

High-throughput

0.249

Low

369072

ASSY
Argininosuccinate synthase

1

0

High-throughput

0.249

Low

554819

ODBA
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

1

0

High-throughput

0.249

Low

1322412

SPICE
Spindle and centriole-associated protein 1

1

0

High-throughput

0.249

Low

1341279

COQ8A
Atypical kinase COQ8A, mitochondrial

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025