HitPredict

Interactor 1: TP4A3 (O75365)
Protein tyrosine phosphatase type IVA 3 (EC 3.1.3.48) (PRL-R) (Protein-tyrosine phosphatase 4a3) (Protein-tyrosine phosphatase of regenerating liver 3) (PRL-3)
Gene: PTP4A3

Interactor 2: UBR5 (O95071)
E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (HECT-type E3 ubiquitin transferase UBR5) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein)
Gene: UBR5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	28675297
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 173 Hs			1 2799
+	Hs
		304218 TPTE2_HUMAN (6-168): 1.11e-42: 150: 15.85		UBR5_HUMAN (1-2799): 0: 3949: 100.00
+	Hs
		304201 TENS3_HUMAN (4-168): 1.59e-40: 147: 14.84		UBR5_HUMAN (1-2799): 0: 3949: 100.00
+	Hs
		304135 DUS2_HUMAN (2-154): 7.14e-31: 115: 18.71		UBR5_HUMAN (1-2799): 0: 3949: 100.00
+	Hs
		260562 TP4A3_HUMAN (1-173): 7.13e-57: 177: 100.00		UBE3C_HUMAN (2301-2796): 5.2e-128: 435: 20.33
+	Hs
		890850 PTEN_HUMAN (5-163): 2.34e-41: 144: 18.86		SMUF1_HUMAN (2357-2796): 2.47e-141: 463: 21.18
+	Hs
		125292 PTEN_HUMAN (5-163): 2.34e-41: 144: 18.86		WWP2_HUMAN (2430-2797): 2.93e-130: 435: 20.94
+	Hs
		879803 TPTE_HUMAN (6-168): 3.19e-40: 144: 15.30		UBE3C_HUMAN (2301-2796): 5.2e-128: 435: 20.33
+	Mm
		139497 PTEN_MOUSE (5-163): 2.46e-41: 144: 18.86		WWP2_MOUSE (2430-2797): 2.32e-129: 432: 21.47
+	Rn
		73303 PTEN_RAT (5-163): 2.29e-41: 144: 18.86		B4F767_RAT (2430-2797): 6.59e-129: 431: 21.47
+	Hs
		890839 PTEN_HUMAN (5-163): 2.34e-41: 144: 18.86		WWP1_HUMAN (2180-2797): 2.84e-126: 425: 18.43
+	Rn
		222447 PTEN_RAT (5-163): 2.29e-41: 144: 18.86		NEDD4_RAT (2189-2796): 2.54e-126: 424: 18.84
+	Hs
		808067 PTEN_HUMAN (5-163): 2.34e-41: 144: 18.86		NEDD4_HUMAN (2446-2796): 8.62e-120: 416: 23.98
+	Sc
		765359 CDC14_YEAST (11-169): 1.4e-37: 137: 22.73		RSP5_YEAST (2187-2797): 2.89e-122: 409: 16.98
+	Hs
		260574 TP4A3_HUMAN (1-173): 7.13e-57: 177: 100.00		HUWE1_HUMAN (2499-2798): 1.29e-100: 366: 27.27
+	Sp
		1350779 FLP1_SCHPO (3-160): 6.58e-39: 140: 21.97		PUB2_SCHPO (2425-2797): 1.42e-119: 397: 23.44
+	Hs
		1167718 TPTE2_HUMAN (6-168): 1.11e-42: 150: 15.85		HUWE1_HUMAN (2499-2798): 1.29e-100: 366: 27.27
+	Hs
		1147694 TENS3_HUMAN (4-168): 1.59e-40: 147: 14.84		HUWE1_HUMAN (2499-2798): 1.29e-100: 366: 27.27
+	Dm
		1181099 Q7KMQ6_DROME (5-152): 5.14e-41: 145: 21.82		Q9VXR3_DROME (2499-2798): 5.82e-100: 364: 25.48
+	Hs
		1144558 TENS2_HUMAN (4-168): 8.07e-39: 142: 13.74		HUWE1_HUMAN (2499-2798): 1.29e-100: 366: 27.27