HitPredict

Interactor 1: TP4A3 (O75365)
Protein tyrosine phosphatase type IVA 3 (EC 3.1.3.48) (PRL-R) (Protein-tyrosine phosphatase 4a3) (Protein-tyrosine phosphatase of regenerating liver 3) (PRL-3)
Gene: PTP4A3

Interactor 2: HUWE1 (Q7Z6Z7)
E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1)
Gene: HUWE1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	27880917, 28675297
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 173 Hs			1 4374
+	Hs
		1167718 TPTE2_HUMAN (6-168): 1.11e-42: 150: 15.85		HUWE1_HUMAN (1-4374): 0: 3240: 100.00
+	Hs
		1147694 TENS3_HUMAN (4-168): 1.59e-40: 147: 14.84		HUWE1_HUMAN (1-4374): 0: 3240: 100.00
+	Hs
		1144558 TENS2_HUMAN (4-168): 8.07e-39: 142: 13.74		HUWE1_HUMAN (1-4374): 0: 3240: 100.00
+	Rn
		222447 PTEN_RAT (5-163): 2.29e-41: 144: 18.86		NEDD4_RAT (3603-4372): 0: 630: 26.96
+	Mm
		139497 PTEN_MOUSE (5-163): 2.46e-41: 144: 18.86		WWP2_MOUSE (3506-4372): 0: 625: 24.44
+	Hs
		125292 PTEN_HUMAN (5-163): 2.34e-41: 144: 18.86		WWP2_HUMAN (3506-4372): 0: 624: 24.57
+	Hs
		890850 PTEN_HUMAN (5-163): 2.34e-41: 144: 18.86		SMUF1_HUMAN (3772-4371): 0: 620: 32.84
+	Rn
		73303 PTEN_RAT (5-163): 2.29e-41: 144: 18.86		B4F767_RAT (3506-4372): 0: 618: 24.57
+	Hs
		890839 PTEN_HUMAN (5-163): 2.34e-41: 144: 18.86		WWP1_HUMAN (3507-4372): 0: 613: 22.55
+	Hs
		808067 PTEN_HUMAN (5-163): 2.34e-41: 144: 18.86		NEDD4_HUMAN (3104-4372): 2.46e-179: 594: 21.46
+	Sc
		765359 CDC14_YEAST (11-169): 1.4e-37: 137: 22.73		RSP5_YEAST (3659-4372): 0: 595: 27.62
+	Sp
		1350779 FLP1_SCHPO (3-160): 6.58e-39: 140: 21.97		PUB2_SCHPO (3745-4372): 4.11e-174: 555: 27.03
+	Dm
		1181099 Q7KMQ6_DROME (5-152): 5.14e-41: 145: 21.82		Q9VXR3_DROME (1-498): 4.03e-145: 515: 44.12