Protein: LRWD1
Leucine-rich repeat and WD repeat-containing protein 1 (Centromere protein 33) (CENP-33) (Origin recognition complex-associated protein) (ORC-associated protein) (ORCA)

Gene: LRWD1
Organism: Homo sapiens
Interactions: 114
UniProt ID: Q9UFC0

Gene Ontology (top 5):
GO:0000776 - kinetochore
GO:0000781 - chromosome, telomeric region
GO:0003682 - chromatin binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1104376

ORC2
Origin recognition complex subunit 2

5

0

Small-scale

0.678

High

1414942

RN126
E3 ubiquitin-protein ligase RNF126

3

0

High-throughput

0.638

High

1434840

STN1
CST complex subunit STN1

3

0

High-throughput

0.638

High

1459108

ORC6
Origin recognition complex subunit 6

3

0

High-throughput

0.638

High

230927

ORC5
Origin recognition complex subunit 5

2

3

Small-scale

0.611

High

231528

ORC4
Origin recognition complex subunit 4

2

2

Small-scale

0.611

High

1104335

ORC1
Origin recognition complex subunit 1

2

2

Small-scale

0.611

High

980486

H4
Histone H4

3

0

High-throughput

0.604

High

1369269

RPGR
X-linked retinitis pigmentosa GTPase regulator

2

0

High-throughput

0.602

High

1405898

DNJC7
DnaJ homolog subfamily C member 7

2

0

High-throughput

0.602

High

1458315

ORC3
Origin recognition complex subunit 3

2

0

Small-scale

0.585

High

1459107

T22D4
TSC22 domain family protein 4

2

0

High-throughput

0.585

High

998911

H31
Histone H3.1

2

2

High-throughput

0.584

High

1112764

CUL1
Cullin-1

2

1

Small-scale

0.584

High

397142

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

373403

MYC
Myc proto-oncogene protein

2

0

High-throughput

0.559

High

900207

FXR1
RNA-binding protein FXR1

2

0

Small-scale

0.559

High

1101921

SKP2
S-phase kinase-associated protein 2

2

0

Small-scale

0.559

High

133140

FOXE1
Forkhead box protein E1

1

3

High-throughput

0.536

High

221974

FOXS1
Forkhead box protein S1

1

3

High-throughput

0.536

High

937663

FOXG1
Forkhead box protein G1

1

3

High-throughput

0.536

High

1061622

FOXM1
Forkhead box protein M1

1

3

High-throughput

0.536

High

1163263

H2B2E
Histone H2B type 2-E

1

1

High-throughput

0.536

High

1386794

GCP3
Gamma-tubulin complex component 3

1

2

High-throughput

0.536

High

1401981

GCP6
Gamma-tubulin complex component 6

1

2

High-throughput

0.536

High

1405197

MPP8
M-phase phosphoprotein 8

1

1

High-throughput

0.536

High

1407768

FOXB1
Forkhead box protein B1

1

5

High-throughput

0.536

High

1412550

GCP2
Gamma-tubulin complex component 2

1

2

High-throughput

0.536

High

1420515

FOXQ1
Forkhead box protein Q1

1

3

High-throughput

0.536

High

259161

DNJA2
DnaJ homolog subfamily A member 2

1

0

High-throughput

0.513

High

655947

TBG1
Tubulin gamma-1 chain

1

0

High-throughput

0.513

High

774125

ADDA
Alpha-adducin

1

0

High-throughput

0.513

High

1111337

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.513

High

1129194

IRF3
Interferon regulatory factor 3

1

0

High-throughput

0.513

High

1150267

TEAD2
Transcriptional enhancer factor TEF-4

1

0

High-throughput

0.513

High

1242580

MZT2A
Mitotic-spindle organizing protein 2A

1

0

High-throughput

0.513

High

1395308

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.513

High

1404475

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.513

High

1412775

FEM1A
Protein fem-1 homolog A

1

0

High-throughput

0.513

High

1452174

ALKB4
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4

1

0

High-throughput

0.513

High

260574

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.479

High

345018

WIZ
Protein Wiz

1

1

Small-scale

0.479

High

443544

CDK1
Cyclin-dependent kinase 1

1

1

Small-scale

0.479

High

558467

XRCC6
X-ray repair cross-complementing protein 6

1

1

Small-scale

0.479

High

559533

XRCC5
X-ray repair cross-complementing protein 5

1

1

Small-scale

0.479

High

668061

CDK2
Cyclin-dependent kinase 2

1

1

Small-scale

0.479

High

981160

H2B1C
Histone H2B type 1-C/E/F/G/I

1

1

High-throughput

0.479

High

1017273

H33
Histone H3.3

1

2

High-throughput

0.479

High

1115116

CUL4A
Cullin-4A

1

1

Small-scale

0.479

High

1141343

BRD3
Bromodomain-containing protein 3

1

1

High-throughput

0.479

High

1155869

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.479

High

1243728

RFWD3
E3 ubiquitin-protein ligase RFWD3

1

1

Small-scale

0.479

High

1290999

TAXB1
Tax1-binding protein 1

1

1

High-throughput

0.479

High

1367503

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

1396318

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

1

Small-scale

0.479

High

1406956

CDC6
Cell division control protein 6 homolog

1

2

Small-scale

0.479

High

1434502

ZN644
Zinc finger protein 644

1

1

Small-scale

0.479

High

1436925

EHMT1
Histone-lysine N-methyltransferase EHMT1

1

1

Small-scale

0.479

High

162727

ANM5
Protein arginine N-methyltransferase 5

1

0

Small-scale

0.458

High

229094

AKAP8
A-kinase anchor protein 8

1

0

Small-scale

0.458

High

248127

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

284358

GEMI
Geminin

1

0

Small-scale

0.458

High

340946

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

1

0

High-throughput

0.458

High

346448

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

363972

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

386332

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

414781

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

419255

H2A1B
Histone H2A type 1-B/E

1

0

High-throughput

0.458

High

508775

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

Small-scale

0.458

High

589950

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

629169

CCNA2
Cyclin-A2

1

0

Small-scale

0.458

High

696773

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

769425

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

895135

EMD
Emerin

1

0

High-throughput

0.458

High

910719

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

0

Small-scale

0.458

High

995871

ACTC
Actin, alpha cardiac muscle 1

1

0

High-throughput

0.458

High

1029965

RUNX1
Runt-related transcription factor 1

1

0

High-throughput

0.458

High

1097612

CBX3
Chromobox protein homolog 3

1

0

High-throughput

0.458

High

1100493

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.458

High

1128137

DHX8
ATP-dependent RNA helicase DHX8

1

0

High-throughput

0.458

High

1134756

NUMA1
Nuclear mitotic apparatus protein 1

1

0

Small-scale

0.458

High

1135153

CUL7
Cullin-7

1

0

High-throughput

0.458

High

1157982

DDB1
DNA damage-binding protein 1

1

0

Small-scale

0.458

High

1217220

RIF1
Telomere-associated protein RIF1

1

0

Small-scale

0.458

High

1219903

OBI1
ORC ubiquitin ligase 1

1

0

Small-scale

0.458

High

1255955

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

1276913

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1294910

KMT5C
Histone-lysine N-methyltransferase KMT5C

1

0

Small-scale

0.458

High

1369080

GGH
Gamma-glutamyl hydrolase

1

0

High-throughput

0.458

High

1380681

FBX32
F-box only protein 32

1

0

High-throughput

0.458

High

1397526

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

1401428

CIC
Protein capicua homolog

1

0

High-throughput

0.458

High

1414609

DDX23
Probable ATP-dependent RNA helicase DDX23

1

0

High-throughput

0.458

High

1415897

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

1434147

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

1450944

NLE1
Notchless protein homolog 1

1

0

High-throughput

0.458

High

1459104

LRWD1
Leucine-rich repeat and WD repeat-containing protein 1

1

0

Small-scale

0.458

High

1459105

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1459106

NUDC
Nuclear migration protein nudC

1

0

High-throughput

0.458

High

1162070

H31T
Histone H3.1t

1

2

High-throughput

0.408

High

887299

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.391

High

1248592

LYPD4
Ly6/PLAUR domain-containing protein 4

2

0

High-throughput

0.328

High

1446014

SYSM
Serine--tRNA ligase, mitochondrial

2

0

High-throughput

0.313

High

347390

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.279

Low

608377

EGLN
Endoglin

1

0

High-throughput

0.279

Low

1009357

PRR3
Proline-rich protein 3

1

0

High-throughput

0.279

Low

1158833

CART

1

0

High-throughput

0.279

Low

1446811

CRAC1
Cartilage acidic protein 1

1

0

High-throughput

0.279

Low

76585

B4DYC6
cDNA FLJ60958, highly similar to Homo sapiens SGT1, suppressor of G2 allele of SKP1

1

0

High-throughput

0.249

Low

157952

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.249

Low

412754

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

888490

TSP3
Thrombospondin-3

1

0

High-throughput

0.249

Low

1120981

TRI29
Tripartite motif-containing protein 29

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025