HitPredict

Interactor 1: H2AY (O75367)
Core histone macro-H2A.1 (Histone macroH2A1) (mH2A1) (Histone H2A.y) (H2A/y) (Medulloblastoma antigen MU-MB-50.205)
Gene: MACROH2A1

Interactor 2: XRCC5 (P13010)
X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining))
Gene: XRCC5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	17158748
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000781 - chromosome, telomeric region GO:0000976 - transcription cis-regulatory region binding GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm and 2 others more... GO:0005730 - nucleolus GO:0090734 - site of DNA damage
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 369 Hs			1 732
+	Hs
		525040 MACD1_HUMAN (172-363): 9.08e-66: 213: 22.56		XRCC5_HUMAN (1-732): 0: 755: 100.00
+	Hs
		524783 H2AX_HUMAN (1-142): 1.07e-65: 206: 60.69		XRCC5_HUMAN (1-732): 0: 755: 100.00
+	Hs
		391527 H2A1B_HUMAN (1-126): 1.27e-64: 203: 62.02		XRCC5_HUMAN (1-732): 0: 755: 100.00
+	Hs
		470247 H2A1_HUMAN (1-126): 1.21e-64: 203: 62.02		XRCC5_HUMAN (1-732): 0: 755: 100.00
+	Hs
		260738 H2AY_HUMAN (1-369): 6.49e-165: 467: 100.00		XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49
+	Hs
		523971 MACD1_HUMAN (172-363): 9.08e-66: 213: 22.56		XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49
+	Hs
		523498 H2AX_HUMAN (1-142): 1.07e-65: 206: 60.69		XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49
+	Hs
		391526 H2A1B_HUMAN (1-126): 1.27e-64: 203: 62.02		XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49
+	Hs
		470246 H2A1_HUMAN (1-126): 1.21e-64: 203: 62.02		XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49
+	Sc
		392562 H2A2_YEAST (14-123): 1.54e-41: 144: 67.27		KU80_YEAST (8-622): 1.51e-99: 321: 14.03
+	Sc
		392196 H2A1_YEAST (14-123): 2.85e-41: 143: 67.27		KU80_YEAST (8-622): 1.51e-99: 321: 14.03
+	Sc
		392362 H2A2_YEAST (14-123): 1.54e-41: 144: 67.27		KU70_YEAST (8-541): 5.97e-92: 300: 16.73
+	Sc
		392088 H2A1_YEAST (14-123): 2.85e-41: 143: 67.27		KU70_YEAST (8-541): 5.97e-92: 300: 16.73