Protein: SNX18
Sorting nexin-18 (SH3 and PX domain-containing protein 3B)

Gene: SNX18
Organism: Homo sapiens
Interactions: 101
UniProt ID: Q96RF0

Gene Ontology (top 5):
GO:0000281 - mitotic cytokinesis
GO:0005546 - phosphatidylinositol-4,5-bisphosphate binding
GO:0005886 - plasma membrane
GO:0006897 - endocytosis
GO:0009898 - cytoplasmic side of plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

896862

DYN2
Dynamin-2

2

14

Small-scale

0.737

High

987876

GRB2
Growth factor receptor-bound protein 2

6

20

High-throughput

0.730

High

1357692

SNX33
Sorting nexin-33

1

18

High-throughput

0.691

High

292862

GRAP2
GRB2-related adapter protein 2

3

20

High-throughput

0.667

High

591352

CD44
CD44 antigen

3

1

High-throughput

0.662

High

760492

SDC2
Syndecan-2

3

3

High-throughput

0.662

High

177295

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

1

6

High-throughput

0.640

High

170296

AURKA
Aurora kinase A

4

8

High-throughput

0.638

High

1401296

SNX18
Sorting nexin-18

1

16

Small-scale

0.618

High

1401307

SNX9
Sorting nexin-9

1

17

Small-scale

0.618

High

1401308

SNX8
Sorting nexin-8

1

16

Small-scale

0.618

High

74364

ZBT42
Zinc finger and BTB domain-containing protein 42

2

6

High-throughput

0.606

High

1063550

GOGA2
Golgin subfamily A member 2

2

1

High-throughput

0.606

High

1308002

RELL1
RELT-like protein 1

2

0

High-throughput

0.602

High

869514

TNFL6
Tumor necrosis factor ligand superfamily member 6

2

2

Small-scale

0.601

High

70432

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.580

High

1093034

CDC16
Cell division cycle protein 16 homolog

2

3

High-throughput

0.574

High

193611

PDPK1
3-phosphoinositide-dependent protein kinase 1

2

4

High-throughput

0.571

High

1227304

A16L1
Autophagy-related protein 16-1

2

6

Small-scale

0.571

High

161075

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

19

Small-scale

0.561

High

1401300

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

4

Small-scale

0.561

High

284713

KHDR3
KH domain-containing, RNA-binding, signal transduction-associated protein 3

2

2

High-throughput

0.553

High

1059722

KRA11
Keratin-associated protein 1-1

2

1

High-throughput

0.553

High

1163755

PTN21
Tyrosine-protein phosphatase non-receptor type 21

2

2

High-throughput

0.553

High

1271205

DPPA4
Developmental pluripotency-associated protein 4

2

2

High-throughput

0.553

High

1401303

ABI2
Abl interactor 2

2

14

High-throughput

0.553

High

242654

PRKN
E3 ubiquitin-protein ligase parkin

1

10

High-throughput

0.553

High

1105762

ADAM9
Disintegrin and metalloproteinase domain-containing protein 9

1

19

Small-scale

0.536

High

260728

RAMP1
Receptor activity-modifying protein 1

1

1

High-throughput

0.536

High

554141

BMP2
Bone morphogenetic protein 2

1

3

High-throughput

0.536

High

718454

CD6
T-cell differentiation antigen CD6

1

1

High-throughput

0.536

High

1022941

EFNB1
Ephrin-B1

1

1

High-throughput

0.536

High

1112668

CUL1
Cullin-1

1

3

High-throughput

0.536

High

1347840

RIN3
Ras and Rab interactor 3

1

5

High-throughput

0.536

High

1401304

ATS1
A disintegrin and metalloproteinase with thrombospondin motifs 1

1

10

High-throughput

0.536

High

1394590

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

3

Small-scale

0.515

High

616086

LAG3
Lymphocyte activation gene 3 protein

1

0

High-throughput

0.513

High

777542

K22E
Keratin, type II cytoskeletal 2 epidermal

1

0

High-throughput

0.513

High

1401299

RFIP5
Rab11 family-interacting protein 5

1

0

Small-scale

0.505

High

328116

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

4

Small-scale

0.501

High

1005385

ADAM8
Disintegrin and metalloproteinase domain-containing protein 8

1

19

Small-scale

0.501

High

335497

SLU7
Pre-mRNA-splicing factor SLU7

1

1

High-throughput

0.489

High

543534

VDR
Vitamin D3 receptor

1

4

High-throughput

0.489

High

1335348

ZN784
Zinc finger protein 784

1

2

High-throughput

0.489

High

1335948

ZBT44
Zinc finger and BTB domain-containing protein 44

1

4

High-throughput

0.489

High

1401301

DISC1
Disrupted in schizophrenia 1 protein

1

4

High-throughput

0.489

High

321803

ABCA8
ABC-type organic anion transporter ABCA8

1

2

High-throughput

0.479

High

346215

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.479

High

651414

CBL
E3 ubiquitin-protein ligase CBL

1

2

Small-scale

0.479

High

1008447

ADA17
Disintegrin and metalloproteinase domain-containing protein 17

1

19

Small-scale

0.479

High

1033166

EWS
RNA-binding protein EWS

1

1

High-throughput

0.479

High

1060691

SOS1
Son of sevenless homolog 1

1

3

Small-scale

0.479

High

1060718

SOS2
Son of sevenless homolog 2

1

3

Small-scale

0.479

High

1391163

BICD1
Protein bicaudal D homolog 1

1

5

High-throughput

0.479

High

419150

H2A1B
Histone H2A type 1-B/E

1

0

High-throughput

0.458

High

616796

SDC1
Syndecan-1

1

3

High-throughput

0.445

High

1401298

LZTS2
Leucine zipper putative tumor suppressor 2

1

6

High-throughput

0.445

High

1401302

EXOC1
Exocyst complex component 1

1

0

High-throughput

0.438

High

106508

APRIO
Alternative prion protein

1

4

High-throughput

0.437

High

173252

XPO1
Exportin-1

1

10

High-throughput

0.437

High

260332

BRD4
Bromodomain-containing protein 4

1

4

High-throughput

0.437

High

262560

MCE1
mRNA-capping enzyme

1

4

High-throughput

0.437

High

674298

BRD2
Bromodomain-containing protein 2

1

6

High-throughput

0.437

High

696269

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.437

High

768946

RFA3
Replication protein A 14 kDa subunit

1

6

High-throughput

0.437

High

831275

CCNF
Cyclin-F

1

1

High-throughput

0.437

High

872652

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.437

High

1115935

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

1

High-throughput

0.437

High

1255154

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.437

High

1329821

SIR6
NAD-dependent protein deacylase sirtuin-6

1

4

High-throughput

0.437

High

1401305

XPO7
Exportin-7

1

8

High-throughput

0.437

High

1401306

ARI1
E3 ubiquitin-protein ligase ARIH1

1

10

High-throughput

0.437

High

1056918

FMR1
Fragile X messenger ribonucleoprotein 1

1

2

High-throughput

0.417

High

765816

BMI1
Polycomb complex protein BMI-1

1

6

High-throughput

0.407

High

829506

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

1

High-throughput

0.407

High

942833

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

8

High-throughput

0.407

High

1145334

RNPS1
RNA-binding protein with serine-rich domain 1

1

2

High-throughput

0.407

High

1278792

HDGR2
Hepatoma-derived growth factor-related protein 2

1

3

High-throughput

0.407

High

1392734

ZN764
Zinc finger protein 764

2

0

High-throughput

0.328

High

269354

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.316

High

1156319

HSPB2
Heat shock protein beta-2

2

0

High-throughput

0.316

High

1196930

MSS51
Putative protein MSS51 homolog, mitochondrial

2

0

High-throughput

0.316

High

1329087

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

2

0

High-throughput

0.316

High

1401297

MDFI
MyoD family inhibitor

2

0

High-throughput

0.316

High

992309

SKP1
S-phase kinase-associated protein 1

2

0

High-throughput

0.313

High

1293802

FBX11
F-box only protein 11

2

0

High-throughput

0.313

High

837377

ASIP
Agouti-signaling protein

1

0

High-throughput

0.279

Low

983945

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

High-throughput

0.279

Low

1059125

PIGF
GPI ethanolamine phosphate transferase, stabilizing subunit

1

0

High-throughput

0.279

Low

1159270

ZNF74
Zinc finger protein 74

1

0

High-throughput

0.279

Low

1280019

CE024
UPF0461 protein C5orf24

1

0

High-throughput

0.279

Low

1186793

KRA63
Keratin-associated protein 6-3

1

0

High-throughput

0.268

Low

1252369

MEX3B
RNA-binding protein MEX3B

1

0

High-throughput

0.249

Low

1311158

UBR2
E3 ubiquitin-protein ligase UBR2

1

0

Small-scale

0.249

Low

294746

PR15A
Protein phosphatase 1 regulatory subunit 15A

1

0

High-throughput

0.232

Low

911347

IMA5
Importin subunit alpha-5

1

0

High-throughput

0.232

Low

935955

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

0

High-throughput

0.232

Low

1243397

TM154
Transmembrane protein 154

1

0

High-throughput

0.232

Low

1326042

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.232

Low

1394879

EAF1
ELL-associated factor 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025