HitPredict

Interactor 1: TRIM3 (O75382)
Tripartite motif-containing protein 3 (EC 2.3.2.27) (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97)
Gene: TRIM3

Interactor 2: UBE2W (Q96B02)
Ubiquitin-conjugating enzyme E2 W (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme W) (N-terminal E2 ubiquitin-conjugating enzyme) (EC 2.3.2.25) (N-terminus-conjugating E2) (Ubiquitin carrier protein W) (Ubiquitin-conjugating enzyme 16) (UBC-16) (Ubiquitin-protein ligase W)
Gene: UBE2W

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	36481767
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4
Common GO terms	GO:0000209 - protein polyubiquitination GO:0005737 - cytoplasm GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 744 Hs			1 151
+	Hs
		262201 TRIM3_HUMAN (1-744): 0: 612: 100.00		UB2D4_HUMAN (4-150): 7.3e-70: 208: 35.37
+	Hs
		262161 TRIM3_HUMAN (1-744): 0: 612: 100.00		UB2D1_HUMAN (4-150): 2.02e-69: 207: 34.69
+	Hs
		262167 TRIM3_HUMAN (1-744): 0: 612: 100.00		UB2D2_HUMAN (4-150): 1.14e-68: 205: 33.33
+	Hs
		262166 TRIM3_HUMAN (1-744): 0: 612: 100.00		UB2D3_HUMAN (4-150): 3.12e-67: 202: 33.33
+	Hs
		262192 TRIM3_HUMAN (1-744): 0: 612: 100.00		UB2E2_HUMAN (1-150): 3.17e-66: 201: 34.67
+	Hs
		262163 TRIM3_HUMAN (1-744): 0: 612: 100.00		UB2E1_HUMAN (1-150): 3.64e-64: 196: 34.00
+	Hs
		1318738 TRIM2_HUMAN (1-744): 0: 565: 66.67		UB2D4_HUMAN (4-150): 7.3e-70: 208: 35.37
+	Hs
		849440 TRIM2_HUMAN (1-744): 0: 565: 66.67		UB2D1_HUMAN (4-150): 2.02e-69: 207: 34.69
+	Hs
		919854 TRIM2_HUMAN (1-744): 0: 565: 66.67		UB2D2_HUMAN (4-150): 1.14e-68: 205: 33.33
+	Hs
		895906 TRIM2_HUMAN (1-744): 0: 565: 66.67		UB2D3_HUMAN (4-150): 3.12e-67: 202: 33.33
+	Hs
		1297367 TRIM2_HUMAN (1-744): 0: 565: 66.67		UB2E2_HUMAN (1-150): 3.17e-66: 201: 34.67
+	Hs
		1282345 TRIM2_HUMAN (1-744): 0: 565: 66.67		UB2E3_HUMAN (1-150): 1.13e-65: 200: 35.33
+	Hs
		851883 TRIM2_HUMAN (1-744): 0: 565: 66.67		UB2E1_HUMAN (1-150): 3.64e-64: 196: 34.00
+	Hs
		1284885 TRIM2_HUMAN (1-744): 0: 565: 66.67		UBE2W_HUMAN (1-151): 1.05e-62: 190: 100.00
+	Hs
		849316 TRI32_HUMAN (1-742): 1.56e-84: 283: 16.38		UB2D1_HUMAN (4-150): 2.02e-69: 207: 34.69
+	Hs
		919715 TRI32_HUMAN (1-742): 1.56e-84: 283: 16.38		UB2D2_HUMAN (4-150): 1.14e-68: 205: 33.33
+	Hs
		895783 TRI32_HUMAN (1-742): 1.56e-84: 283: 16.38		UB2D3_HUMAN (4-150): 3.12e-67: 202: 33.33
+	Hs
		1023317 TRI32_HUMAN (1-742): 1.56e-84: 283: 16.38		UB2E2_HUMAN (1-150): 3.17e-66: 201: 34.67
+	Hs
		1023307 TRI32_HUMAN (1-742): 1.56e-84: 283: 16.38		UB2E3_HUMAN (1-150): 1.13e-65: 200: 35.33
+	Hs
		851808 TRI32_HUMAN (1-742): 1.56e-84: 283: 16.38		UB2E1_HUMAN (1-150): 3.64e-64: 196: 34.00