Protein: GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

Gene: GPC1
Organism: Homo sapiens
Interactions: 200
UniProt ID: P35052

Gene Ontology (top 5):
GO:0005507 - copper ion binding
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005654 - nucleoplasm
GO:0005768 - endosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

762354

CAMKV
CaM kinase-like vesicle-associated protein

4

3

High-throughput

0.697

High

762356

ERMAP
Erythroid membrane-associated protein

1

1

High-throughput

0.691

High

426943

FGF1
Fibroblast growth factor 1

3

8

High-throughput

0.667

High

733486

GP183
G-protein coupled receptor 183

3

7

High-throughput

0.667

High

762317

CEAM7
Cell adhesion molecule CEACAM7

1

1

High-throughput

0.665

High

762279

ECHB
Trifunctional enzyme subunit beta, mitochondrial

3

3

High-throughput

0.662

High

193517

PDPK1
3-phosphoinositide-dependent protein kinase 1

3

3

High-throughput

0.650

High

762363

XYLT2
Xylosyltransferase 2

2

1

High-throughput

0.628

High

762377

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

2

1

High-throughput

0.628

High

522604

PTPRF
Receptor-type tyrosine-protein phosphatase F

1

8

High-throughput

0.618

High

762357

HBEGF
Proheparin-binding EGF-like growth factor [Cleaved into: Heparin-binding EGF-like growth factor

2

1

High-throughput

0.611

High

661230

AT2B4
Plasma membrane calcium-transporting ATPase 4

2

0

High-throughput

0.602

High

762338

TM214
Transmembrane protein 214

2

0

High-throughput

0.602

High

762365

FANCE
Fanconi anemia group E protein

2

0

High-throughput

0.602

High

762339

CAVN1
Caveolae-associated protein 1

2

2

High-throughput

0.601

High

762348

LRRT4
Leucine-rich repeat transmembrane neuronal protein 4

2

13

High-throughput

0.601

High

762349

LRRT3
Leucine-rich repeat transmembrane neuronal protein 3

2

13

High-throughput

0.601

High

762371

DAXX
Death domain-associated protein 6

2

1

High-throughput

0.601

High

507595

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

1

High-throughput

0.595

High

762283

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

2

1

Small-scale

0.595

High

762263

BASI
Basigin

2

2

High-throughput

0.584

High

762325

SPCS2
Signal peptidase complex subunit 2

2

2

High-throughput

0.574

High

762319

DAG1
Dystroglycan 1

2

1

Small-scale

0.571

High

317553

SLIT2
Slit homolog 2 protein

1

2

Small-scale

0.561

High

385498

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

2

0

High-throughput

0.559

High

762268

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

2

7

High-throughput

0.549

High

472389

FGF4
Fibroblast growth factor 4

1

8

High-throughput

0.536

High

483671

WNT2
Protein Wnt-2

1

5

High-throughput

0.536

High

567806

PRG2
Bone marrow proteoglycan

1

3

High-throughput

0.536

High

762264

SRP14
Signal recognition particle 14 kDa protein

1

1

High-throughput

0.536

High

762274

SRP09
Signal recognition particle 9 kDa protein

1

2

High-throughput

0.536

High

762276

TUB
Tubby protein homolog

1

4

High-throughput

0.536

High

762334

ODAPH
Odontogenesis associated phosphoprotein

1

1

High-throughput

0.536

High

762361

RTN4R
Reticulon-4 receptor

1

14

High-throughput

0.536

High

762372

ALK
ALK tyrosine kinase receptor

1

1

High-throughput

0.536

High

762375

FLVC1
Choline/ethanolamine transporter FLVCR1

1

1

High-throughput

0.536

High

762358

CGRF1
Cell growth regulator with RING finger domain protein 1

1

0

High-throughput

0.513

High

421597

A4
Amyloid-beta precursor protein

1

4

Small-scale

0.501

High

585439

VEGFA
Vascular endothelial growth factor A, long form

1

1

Small-scale

0.501

High

762376

SPCS1
Signal peptidase complex subunit 1

1

1

High-throughput

0.489

High

131137

CLIC1
Chloride intracellular channel protein 1

1

1

High-throughput

0.479

High

161005

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

1

High-throughput

0.479

High

214719

HNRPR
Heterogeneous nuclear ribonucleoprotein R

1

1

High-throughput

0.479

High

250479

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

1

High-throughput

0.479

High

253056

PLIN3
Perilipin-3

1

1

High-throughput

0.479

High

278024

FLNB
Filamin-B

1

2

High-throughput

0.479

High

362862

EGFR
Epidermal growth factor receptor

1

3

High-throughput

0.479

High

365312

PGK1
Phosphoglycerate kinase 1

1

1

High-throughput

0.479

High

366470

UROK
Urokinase-type plasminogen activator

1

11

High-throughput

0.479

High

403066

PDGFA
Platelet-derived growth factor subunit A

1

1

High-throughput

0.479

High

409284

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

1

High-throughput

0.479

High

410662

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

3

High-throughput

0.479

High

431727

ITB1
Integrin beta-1

1

1

High-throughput

0.479

High

445136

S10A6
Protein S100-A6

1

5

High-throughput

0.479

High

446697

NPM
Nucleophosmin

1

1

High-throughput

0.479

High

555904

CADH1
Cadherin-1

1

2

High-throughput

0.479

High

583205

FOLR1
Folate receptor alpha

1

1

High-throughput

0.479

High

586539

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.479

High

592626

ITB4
Integrin beta-4

1

10

High-throughput

0.479

High

637367

FLNA
Filamin-A

1

2

High-throughput

0.479

High

646697

CADH3
Cadherin-3

1

2

High-throughput

0.479

High

656052

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

1

High-throughput

0.479

High

665386

EF1B
Elongation factor 1-beta

1

1

High-throughput

0.479

High

687903

EF1G
Elongation factor 1-gamma

1

1

High-throughput

0.479

High

690773

1433T
14-3-3 protein theta

1

3

High-throughput

0.479

High

698430

CALX
Calnexin

1

4

High-throughput

0.479

High

714767

EF1D
Elongation factor 1-delta

1

1

High-throughput

0.479

High

730414

1433S
14-3-3 protein sigma

1

3

High-throughput

0.479

High

731757

S10AB
Protein S100-A11

1

5

High-throughput

0.479

High

761553

HSP74
Heat shock 70 kDa protein 4

1

1

High-throughput

0.479

High

762265

HSPA9
Stress-70 protein, mitochondrial

1

2

High-throughput

0.479

High

762266

TCPZ
T-complex protein 1 subunit zeta

1

1

High-throughput

0.479

High

762271

RS5
Small ribosomal subunit protein uS7

1

1

High-throughput

0.479

High

762292

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

1

High-throughput

0.479

High

762293

FKB1A
Peptidyl-prolyl cis-trans isomerase FKBP1A

1

1

High-throughput

0.479

High

762297

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.479

High

762303

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

2

High-throughput

0.479

High

762305

REL
Proto-oncogene c-Rel

1

4

High-throughput

0.479

High

762306

1433F
14-3-3 protein eta

1

3

High-throughput

0.479

High

762310

ILF3
Interleukin enhancer-binding factor 3

1

2

High-throughput

0.479

High

762311

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

3

High-throughput

0.479

High

762312

ROA0
Heterogeneous nuclear ribonucleoprotein A0

1

1

High-throughput

0.479

High

762314

SQSTM
Sequestosome-1

1

1

High-throughput

0.479

High

762315

LAMB3
Laminin subunit beta-3

1

1

High-throughput

0.479

High

762316

LAMC2
Laminin subunit gamma-2

1

3

High-throughput

0.479

High

762320

DSG2
Desmoglein-2

1

3

High-throughput

0.479

High

762322

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

2

High-throughput

0.479

High

762326

TNIP1
TNFAIP3-interacting protein 1

1

3

High-throughput

0.479

High

762327

PLEC
Plectin

1

2

High-throughput

0.479

High

762332

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.479

High

762333

LAMA3
Laminin subunit alpha-3

1

3

High-throughput

0.479

High

762337

IFIX
Pyrin and HIN domain-containing protein 1

1

3

High-throughput

0.479

High

762350

TAXB1
Tax1-binding protein 1

1

3

High-throughput

0.479

High

762352

TXND5
Thioredoxin domain-containing protein 5

1

2

High-throughput

0.479

High

762359

MEP50
Methylosome protein WDR77

1

1

High-throughput

0.479

High

762362

RGAP1
Rac GTPase-activating protein 1

1

1

High-throughput

0.479

High

762366

S10AE
Protein S100-A14

1

5

High-throughput

0.479

High

762367

ANLN
Anillin

1

1

High-throughput

0.479

High

762370

HDAC6
Protein deacetylase HDAC6

1

1

High-throughput

0.479

High

162793

NHRF1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1

1

0

High-throughput

0.458

High

217889

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

247699

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

302248

STC2
Stanniocalcin-2

1

0

High-throughput

0.458

High

371310

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

402867

ANXA1
Annexin A1

1

0

High-throughput

0.458

High

447688

TPM3
Tropomyosin alpha-3 chain

1

0

High-throughput

0.458

High

458671

SAP
Prosaposin

1

0

High-throughput

0.458

High

476574

RSSA
Small ribosomal subunit protein uS2

1

0

High-throughput

0.458

High

486543

TACD2
Tumor-associated calcium signal transducer 2

1

0

High-throughput

0.458

High

533605

CLUS
Clusterin

1

0

High-throughput

0.458

High

561346

TDGF1
Protein Cripto

1

0

Small-scale

0.458

High

583824

UCHL3
Ubiquitin carboxyl-terminal hydrolase isozyme L3

1

0

High-throughput

0.458

High

591233

CD44
CD44 antigen

1

0

High-throughput

0.458

High

599549

STMN1
Stathmin

1

0

High-throughput

0.458

High

601577

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

High-throughput

0.458

High

620158

NUCL
Nucleolin

1

0

High-throughput

0.458

High

659739

SAHH
Adenosylhomocysteinase

1

0

High-throughput

0.458

High

660538

IF4B
Eukaryotic translation initiation factor 4B

1

0

High-throughput

0.458

High

683584

ITA3
Integrin alpha-3

1

0

High-throughput

0.458

High

685990

RL13
Large ribosomal subunit protein eL13

1

0

High-throughput

0.458

High

687641

SYTC
Threonine--tRNA ligase 1, cytoplasmic

1

0

High-throughput

0.458

High

705254

GRN
Progranulin

1

0

High-throughput

0.458

High

716403

PRDX5
Peroxiredoxin-5, mitochondrial

1

0

High-throughput

0.458

High

716763

RL12
Large ribosomal subunit protein uL11

1

0

High-throughput

0.458

High

717192

KCY
UMP-CMP kinase

1

0

High-throughput

0.458

High

731005

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.458

High

762262

CTNB1
Catenin beta-1

1

0

High-throughput

0.458

High

762267

MDHC
Malate dehydrogenase, cytoplasmic

1

0

High-throughput

0.458

High

762270

RL27A
Large ribosomal subunit protein uL15

1

0

High-throughput

0.458

High

762273

TCPG
T-complex protein 1 subunit gamma

1

0

High-throughput

0.458

High

762275

HINT1
Adenosine 5'-monophosphoramidase HINT1

1

0

High-throughput

0.458

High

762277

RL14
Large ribosomal subunit protein eL14

1

0

High-throughput

0.458

High

762278

RAB7A
Ras-related protein Rab-7a

1

0

High-throughput

0.458

High

762281

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

0

High-throughput

0.458

High

762282

TPIS
Triosephosphate isomerase

1

0

High-throughput

0.458

High

762284

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.458

High

762286

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

0

High-throughput

0.458

High

762287

1433E
14-3-3 protein epsilon

1

0

High-throughput

0.458

High

762288

RL7A
Large ribosomal subunit protein eL8

1

0

High-throughput

0.458

High

762289

RL23A
Large ribosomal subunit protein uL23

1

0

High-throughput

0.458

High

762290

RS25
Small ribosomal subunit protein eS25

1

0

High-throughput

0.458

High

762291

RL11
Large ribosomal subunit protein uL5

1

0

High-throughput

0.458

High

762294

RACK1
Small ribosomal subunit protein RACK1

1

0

High-throughput

0.458

High

762295

YBOX1
Y-box-binding protein 1

1

0

High-throughput

0.458

High

762299

DHSO
Sorbitol dehydrogenase

1

0

High-throughput

0.458

High

762300

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

0

High-throughput

0.458

High

762301

SRSF2
Serine/arginine-rich splicing factor 2

1

0

High-throughput

0.458

High

762302

CAP1
Adenylyl cyclase-associated protein 1

1

0

High-throughput

0.458

High

762304

RL6
Large ribosomal subunit protein eL6

1

0

High-throughput

0.458

High

762313

G3BP1
Ras GTPase-activating protein-binding protein 1

1

0

High-throughput

0.458

High

762318

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

0

High-throughput

0.458

High

762321

SRC8
Src substrate cortactin

1

0

High-throughput

0.458

High

762323

CAPR1
Caprin-1

1

0

High-throughput

0.458

High

762324

FGFP1
Fibroblast growth factor-binding protein 1

1

0

High-throughput

0.458

High

762328

IPYR
Inorganic pyrophosphatase

1

0

High-throughput

0.458

High

762329

SF3A1
Splicing factor 3A subunit 1

1

0

High-throughput

0.458

High

762330

MARE1
Microtubule-associated protein RP/EB family member 1

1

0

High-throughput

0.458

High

762331

VAS1
V-type proton ATPase subunit S1

1

0

High-throughput

0.458

High

762345

SLN11
Schlafen family member 11

1

0

High-throughput

0.458

High

762360

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

762373

NSF1C
NSFL1 cofactor p47

1

0

High-throughput

0.458

High

762374

STRAP
Serine-threonine kinase receptor-associated protein

1

0

High-throughput

0.458

High

215983

FIBP
Acidic fibroblast growth factor intracellular-binding protein

1

2

High-throughput

0.445

High

450171

GDN
Glia-derived nexin

1

3

High-throughput

0.445

High

639108

SYT1
Synaptotagmin-1

1

3

High-throughput

0.445

High

722863

SSR2
Somatostatin receptor type 2

1

4

High-throughput

0.445

High

762269

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

1

High-throughput

0.445

High

762272

P2RY1
P2Y purinoceptor 1

1

7

High-throughput

0.445

High

762308

ECHP
Peroxisomal bifunctional enzyme

1

7

High-throughput

0.445

High

762336

PKHA7
Pleckstrin homology domain-containing family A member 7

1

2

High-throughput

0.445

High

762347

LRRT1
Leucine-rich repeat transmembrane neuronal protein 1

1

14

High-throughput

0.445

High

762351

SYT2
Synaptotagmin-2

1

3

High-throughput

0.445

High

762309

FSTL1
Follistatin-related protein 1

1

0

Small-scale

0.438

High

571382

GLU2B
Glucosidase 2 subunit beta

1

1

High-throughput

0.437

High

595695

H13
Histone H1.3

1

1

High-throughput

0.437

High

706077

S10A2
Protein S100-A2

1

5

High-throughput

0.437

High

762280

NP1L1
Nucleosome assembly protein 1-like 1

1

1

High-throughput

0.437

High

762340

GP179
Probable G-protein coupled receptor 179

1

1

Small-scale

0.437

High

762342

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

220574

AKA10
A-kinase anchor protein 10, mitochondrial

1

0

High-throughput

0.426

High

253816

TPST2
Protein-tyrosine sulfotransferase 2

1

0

High-throughput

0.426

High

269997

XYLK
Glycosaminoglycan xylosylkinase

1

0

Small-scale

0.426

High

547975

PSPC
Surfactant protein C

1

0

High-throughput

0.426

High

762307

FMR1
Fragile X messenger ribonucleoprotein 1

1

0

High-throughput

0.426

High

762353

UXS1
UDP-glucuronic acid decarboxylase 1

1

0

High-throughput

0.426

High

762368

DDX28
Probable ATP-dependent RNA helicase DDX28

1

0

High-throughput

0.426

High

170680

CLGN
Calmegin

1

4

High-throughput

0.407

High

337693

SGPL1
Sphingosine-1-phosphate lyase 1

1

2

High-throughput

0.407

High

762355

TEAN2
Transcription elongation factor A N-terminal and central domain-containing protein 2

1

2

High-throughput

0.407

High

762296

SC11A
Signal peptidase complex catalytic subunit SEC11A

2

0

High-throughput

0.328

High

762364

TM245
Transmembrane protein 245

2

0

High-throughput

0.328

High

762285

SPCS3
Signal peptidase complex subunit 3

1

0

High-throughput

0.279

Low

762343

ERMP1
Endoplasmic reticulum metallopeptidase 1

1

0

High-throughput

0.279

Low

762369

RMND1
Required for meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.279

Low

215396

TPD54
Tumor protein D54

1

0

High-throughput

0.249

Low

762298

ERH
Enhancer of rudimentary homolog

1

0

High-throughput

0.249

Low

762346

OAF
Out at first protein homolog

1

0

High-throughput

0.249

Low

762341

DUX4C
Double homeobox protein 4C

1

0

High-throughput

0.238

Low

762335

NCBP3
Nuclear cap-binding protein subunit 3

1

0

High-throughput

0.232

Low

762344

HDGR2
Hepatoma-derived growth factor-related protein 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025