HitPredict

Interactor 1: PR40A (O75400)
Pre-mRNA-processing factor 40 homolog A (Fas ligand-associated factor 1) (Formin-binding protein 11) (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein 10) (HIP-10) (Huntingtin-interacting protein A) (Renal carcinoma antigen NY-REN-6)
Gene: PRPF40A

Interactor 2: RU17 (P08621)
U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70)
Gene: SNRNP70

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.600

Property	Details
Experiments	29802200, 15231748
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0005685 - U1 snRNP GO:0016607 - nuclear speck and 1 others more... GO:0071004 - U2-type prespliceosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 957 Hs			1 437
+	Hs
		263754 PR40A_HUMAN (1-957): 5.9e-97: 328: 100.00		PPIL4_HUMAN (63-356): 2.16e-35: 138: 17.17
+	Hs
		235624 PR40A_HUMAN (1-957): 5.9e-97: 328: 100.00		HNRPQ_HUMAN (4-313): 1.11e-16: 84.2: 13.55
+	Hs
		516402 YAP1_HUMAN (34-410): 2.24e-42: 164: 10.05		PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08
+	Hs
		808925 YAP1_HUMAN (34-410): 2.24e-42: 164: 10.05		PABP3_HUMAN (4-361): 3.46e-50: 181: 11.86
+	Hs
		441945 YAP1_HUMAN (34-410): 2.24e-42: 164: 10.05		RU17_HUMAN (1-437): 8.99e-46: 165: 100.00
+	Hs
		1219665 RHG12_HUMAN (87-632): 2.86e-43: 171: 13.97		PPIL4_HUMAN (63-356): 2.16e-35: 138: 17.17
+	Hs
		269201 WBP4_HUMAN (102-385): 6.66e-27: 115: 14.68		PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08
+	Hs
		1259877 ITSN2_HUMAN (41-720): 9.42e-36: 149: 9.78		PPIL4_HUMAN (63-356): 2.16e-35: 138: 17.17
+	Sp
		143342 PRP40_SCHPO (111-742): 1.97e-24: 111: 17.71		RU17_SCHPO (1-277): 2.14e-51: 175: 38.27
+	Hs
		516643 ITCH_HUMAN (4-297): 3.34e-18: 92.1: 13.95		PABP1_HUMAN (4-361): 2.68e-53: 190: 11.08
+	Hs
		269198 WBP4_HUMAN (102-385): 6.66e-27: 115: 14.68		RU17_HUMAN (1-437): 8.99e-46: 165: 100.00
+	Dm
		565324 Q9VQK5_DROME (93-715): 2.58e-15: 82.7: 17.57		RU17_DROME (1-212): 1.83e-50: 178: 68.40
+	Hs
		808914 YAP1_HUMAN (34-410): 2.24e-42: 164: 10.05		CSTFT_HUMAN (84-177): 2.89e-20: 95.3: 30.85
+	Sc
		703256 PRP40_YEAST (144-667): 4.38e-18: 91.1: 16.90		RU17_YEAST (3-297): 9.1e-46: 162: 26.58
+	Hs
		235750 YAP1_HUMAN (34-410): 2.24e-42: 164: 10.05		HNRPQ_HUMAN (4-313): 1.11e-16: 84.2: 13.55
+	Hs
		441911 MYH10_HUMAN (432-957): 1.68e-14: 80.8: 9.98		RU17_HUMAN (1-437): 8.99e-46: 165: 100.00
+	Hs
		125103 WWP2_HUMAN (4-227): 1.27e-13: 77.3: 12.86		RU17_HUMAN (1-437): 8.99e-46: 165: 100.00
+	Sc
		376704 PRP40_YEAST (144-667): 4.38e-18: 91.1: 16.90		PABP_YEAST (2-281): 3.47e-29: 121: 12.15
+	Hs
		269205 WBP4_HUMAN (102-385): 6.66e-27: 115: 14.68		TIA1_HUMAN (98-338): 2.21e-18: 88.4: 12.95
+	Hs
		125031 WWP2_HUMAN (4-227): 1.27e-13: 77.3: 12.86		HNRPQ_HUMAN (4-313): 1.11e-16: 84.2: 13.55