Protein: IF4G2
Eukaryotic translation initiation factor 4 gamma 2 (eIF-4-gamma 2) (eIF-4G 2) (eIF4G 2) (Death-associated protein 5) (DAP-5) (p97)

Gene: IF4G2, EIF4G2
Organism: Homo sapiens
Interactions: 143
UniProt ID: P78344

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0003729 - mRNA binding
GO:0003743 - translation initiation factor activity
GO:0005829 - cytosol
GO:0005912 - adherens junction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

953855

IF4A1
Eukaryotic initiation factor 4A-I

12

20

Small-scale

0.980

High

1005671

IF4A2
Eukaryotic initiation factor 4A-II

3

20

Small-scale

0.839

High

1005692

DDX60
Probable ATP-dependent RNA helicase DDX60

1

3

High-throughput

0.691

High

1005677

NADC
Nicotinate-nucleotide pyrophosphorylase [carboxylating]

3

1

High-throughput

0.667

High

141417

DDX3X
ATP-dependent RNA helicase DDX3X

1

4

High-throughput

0.618

High

315441

RECQ4
ATP-dependent DNA helicase Q4

1

8

High-throughput

0.618

High

1005662

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

5

High-throughput

0.618

High

1005673

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

5

High-throughput

0.618

High

1005698

SERB1
SERPINE1 mRNA-binding protein 1

2

1

High-throughput

0.611

High

848121

MAGA1
Melanoma-associated antigen 1

3

5

High-throughput

0.609

High

529606

TAU
Microtubule-associated protein tau

2

2

High-throughput

0.601

High

241369

PRKN
E3 ubiquitin-protein ligase parkin

2

9

High-throughput

0.584

High

363123

EGFR
Epidermal growth factor receptor

2

3

High-throughput

0.584

High

375391

RASK
GTPase KRas

2

5

High-throughput

0.584

High

445529

IF4E
Eukaryotic translation initiation factor 4E

2

18

Small-scale

0.584

High

536950

HSP7C
Heat shock cognate 71 kDa protein

2

4

High-throughput

0.584

High

714022

PML
Protein PML

2

3

High-throughput

0.584

High

830544

CCNF
Cyclin-F

2

4

High-throughput

0.584

High

1005731

YTHD2
YTH domain-containing family protein 2

2

5

High-throughput

0.584

High

415497

HSPB1
Heat shock protein beta-1

1

2

High-throughput

0.582

High

395880

ESR1
Estrogen receptor

2

8

High-throughput

0.571

High

1005682

A16L1
Autophagy-related protein 16-1

2

5

High-throughput

0.571

High

1005696

NGEF
Ephexin-1

2

3

High-throughput

0.571

High

1005727

PNMA2
Paraneoplastic antigen Ma2

2

1

High-throughput

0.549

High

923580

TTC3
E3 ubiquitin-protein ligase TTC3

1

9

High-throughput

0.541

High

346950

BAG2
BAG family molecular chaperone regulator 2

1

1

High-throughput

0.536

High

407072

HG2A
HLA class II histocompatibility antigen gamma chain

1

2

High-throughput

0.536

High

446894

NPM
Nucleophosmin

1

3

High-throughput

0.536

High

534926

BIP
Endoplasmic reticulum chaperone BiP

1

6

High-throughput

0.536

High

611829

RL35A
Large ribosomal subunit protein eL33

1

1

High-throughput

0.536

High

625307

CSK22
Casein kinase II subunit alpha'

1

5

High-throughput

0.536

High

652303

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

2

High-throughput

0.536

High

897005

MAP2
Methionine aminopeptidase 2

1

2

High-throughput

0.536

High

939303

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

12

High-throughput

0.536

High

1005663

TRAF2
TNF receptor-associated factor 2

1

2

High-throughput

0.536

High

1005707

EFMT3
EEF1A lysine methyltransferase 3

1

3

High-throughput

0.536

High

1005729

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

2

High-throughput

0.536

High

588448

RFA2
Replication protein A 32 kDa subunit

2

5

High-throughput

0.535

High

627635

IF2B
Eukaryotic translation initiation factor 2 subunit 2

1

5

Small-scale

0.534

High

105740

APRIO
Alternative prion protein

2

1

High-throughput

0.533

High

848366

MAGA6
Melanoma-associated antigen 6

1

5

High-throughput

0.515

High

1005715

MKNK1
MAP kinase-interacting serine/threonine-protein kinase 1

1

5

Small-scale

0.515

High

274531

DNJB6
DnaJ homolog subfamily B member 6

1

0

High-throughput

0.513

High

1005665

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

0

High-throughput

0.513

High

1005706

TANK
TRAF family member-associated NF-kappa-B activator

1

0

High-throughput

0.513

High

1005708

P5CR2
Pyrroline-5-carboxylate reductase 2

1

0

High-throughput

0.513

High

1005711

DCNL1
DCN1-like protein 1

1

0

High-throughput

0.513

High

185605

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

6

High-throughput

0.501

High

964213

SUMO2
Small ubiquitin-related modifier 2

1

7

High-throughput

0.501

High

1005659

HTRA4
Serine protease HTRA4

1

2

High-throughput

0.489

High

1005694

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

1

High-throughput

0.489

High

555466

SKIL
Ski-like protein

1

0

High-throughput

0.486

High

1005704

CBP
CREB-binding protein

1

4

Small-scale

0.481

High

131397

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

5

High-throughput

0.479

High

131939

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

5

High-throughput

0.479

High

157226

CTRO
Citron Rho-interacting kinase

1

4

High-throughput

0.479

High

172694

XPO1
Exportin-1

1

8

High-throughput

0.479

High

247286

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

6

High-throughput

0.479

High

295320

EIF3J
Eukaryotic translation initiation factor 3 subunit J

1

1

Small-scale

0.479

High

298350

DNJC8
DnaJ homolog subfamily C member 8

1

1

High-throughput

0.479

High

426249

IF2A
Eukaryotic translation initiation factor 2 subunit 1

1

3

Small-scale

0.479

High

445818

ENOA
Alpha-enolase

1

1

High-throughput

0.479

High

487186

PARP1
Poly [ADP-ribose] polymerase 1

1

3

High-throughput

0.479

High

556009

CADH1
Cadherin-1

1

3

High-throughput

0.479

High

565341

ITA4
Integrin alpha-4

1

1

High-throughput

0.479

High

642795

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

4

High-throughput

0.479

High

731193

STIP1
Stress-induced-phosphoprotein 1

1

6

High-throughput

0.479

High

887964

MCM2
DNA replication licensing factor MCM2

1

2

High-throughput

0.479

High

897734

CDK9
Cyclin-dependent kinase 9

1

4

High-throughput

0.479

High

934450

TERA
Transitional endoplasmic reticulum ATPase

1

5

High-throughput

0.479

High

954092

RS20
Small ribosomal subunit protein uS10

1

3

High-throughput

0.479

High

979483

H4
Histone H4

1

3

High-throughput

0.479

High

997628

CSK21
Casein kinase II subunit alpha

1

9

Small-scale

0.479

High

1005661

KIF23
Kinesin-like protein KIF23

1

2

High-throughput

0.479

High

1005664

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

2

High-throughput

0.479

High

1005666

G3BP1
Ras GTPase-activating protein-binding protein 1

1

6

High-throughput

0.479

High

1005667

BIRC3
Baculoviral IAP repeat-containing protein 3

1

4

High-throughput

0.479

High

1005668

SQSTM
Sequestosome-1

1

5

High-throughput

0.479

High

1005670

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

9

Small-scale

0.479

High

1005675

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

11

High-throughput

0.479

High

1005676

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

1005678

PCBP1
Poly(rC)-binding protein 1

1

5

Small-scale

0.479

High

1005679

MARE1
Microtubule-associated protein RP/EB family member 1

1

1

High-throughput

0.479

High

1005681

FBW10
F-box/WD repeat-containing protein 10

1

9

High-throughput

0.479

High

1005686

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

3

High-throughput

0.479

High

1005688

YTHD3
YTH domain-containing family protein 3

1

5

High-throughput

0.479

High

1005690

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

1005699

NUP43
Nucleoporin Nup43

1

9

High-throughput

0.479

High

1005701

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

1

High-throughput

0.479

High

1005703

HDAC2
Histone deacetylase 2

1

5

High-throughput

0.479

High

1005709

OPTN
Optineurin

1

4

High-throughput

0.479

High

1005716

RN126
E3 ubiquitin-protein ligase RNF126

1

1

High-throughput

0.479

High

1005717

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.479

High

1005718

YTHD1
YTH domain-containing family protein 1

1

5

High-throughput

0.479

High

1005721

RC3H2
Roquin-2

1

4

High-throughput

0.479

High

1005722

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

Small-scale

0.479

High

1005723

TLS1
Splicing factor C9orf78

1

3

High-throughput

0.479

High

1005725

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

1005726

UBQL2
Ubiquilin-2

1

3

High-throughput

0.479

High

1005728

FZR1
Fizzy-related protein homolog

1

8

High-throughput

0.479

High

1005660

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

0.458

High

1005674

HERP1
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

1

0

High-throughput

0.458

High

1005689

EST1A
Telomerase-binding protein EST1A

1

0

High-throughput

0.458

High

1005693

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.458

High

1005700

ASB11
Ankyrin repeat and SOCS box protein 11

1

0

High-throughput

0.458

High

1005724

ZO2
Tight junction protein 2

1

0

High-throughput

0.458

High

1005730

GSTK1
Glutathione S-transferase kappa 1

1

0

High-throughput

0.458

High

187942

EIF3H
Eukaryotic translation initiation factor 3 subunit H

1

6

High-throughput

0.445

High

230173

S28A2
Sodium/nucleoside cotransporter 2

1

1

High-throughput

0.445

High

344164

PTBP3
Polypyrimidine tract-binding protein 3

1

8

High-throughput

0.445

High

942549

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

3

High-throughput

0.445

High

1005669

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.445

High

1005672

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

1

High-throughput

0.445

High

1005713

S45A3
Solute carrier family 45 member 3

1

1

High-throughput

0.445

High

1005714

CDC5L
Cell division cycle 5-like protein

1

2

High-throughput

0.445

High

259779

BRD4
Bromodomain-containing protein 4

1

4

High-throughput

0.437

High

277344

TP4A3
Protein tyrosine phosphatase type IVA 3

1

1

High-throughput

0.437

High

302807

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

3

High-throughput

0.437

High

318722

RHBT1
Rho-related BTB domain-containing protein 1

1

6

High-throughput

0.437

High

334541

ZBT7A
Zinc finger and BTB domain-containing protein 7A

1

1

Small-scale

0.437

High

371731

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.437

High

389275

FINC
Fibronectin

1

3

High-throughput

0.437

High

411725

NTRK1
High affinity nerve growth factor receptor

1

6

High-throughput

0.437

High

695190

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.437

High

767942

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.437

High

1005683

LMBRL
Protein LMBR1L

1

4

High-throughput

0.437

High

1005684

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.437

High

1005685

MOB3C
MOB kinase activator 3C

1

1

High-throughput

0.437

High

1005687

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.437

High

1005691

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.437

High

1005702

ESR2
Estrogen receptor beta

1

8

High-throughput

0.437

High

1005720

PKHA4
Pleckstrin homology domain-containing family A member 4

1

6

High-throughput

0.437

High

1005680

UT2
Urea transporter 2

1

0

High-throughput

0.426

High

886738

CEBPA
CCAAT/enhancer-binding protein alpha

1

5

High-throughput

0.408

High

619732

VCAM1
Vascular cell adhesion protein 1

1

2

High-throughput

0.407

High

1005719

S6A16
Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5

1

2

High-throughput

0.407

High

416005

CP1A1
Cytochrome P450 1A1

3

0

High-throughput

0.347

High

505817

C1T9A
Complement C1q and tumor necrosis factor-related protein 9A

1

0

High-throughput

0.282

High

1005712

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.282

High

1005697

FA24B
Protein FAM24B

1

0

High-throughput

0.279

Low

1005705

GGH
Gamma-glutamyl hydrolase

1

0

High-throughput

0.279

Low

1005710

RMC1
Regulator of MON1-CCZ1 complex

1

0

High-throughput

0.279

Low

1005695

NIN
Ninein

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025