Interactor 1: CDC45 (O75419)
Cell division control protein 45 homolog (PORC-PI-1)
Gene: CDC45

Interactor 2: MCM7 (P33993)
DNA replication licensing factor MCM7 (EC 3.6.4.12) (CDC47 homolog) (P1.1-MCM3)
Gene: MCM7

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.77 1.00 0.878

The method score is based on:

Property Details
Experiments 12614612, 23364835, 10518787, 16912045
Identification Methods two hybrid, affinity chromatography technology, pull down
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains CDC45~MCM_lid, CDC45~MCM_N, CDC45~MCM_OB
Common GO terms GO:0000727 - double-strand break repair via break-induced replication
GO:0003697 - single-stranded DNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006268 - DNA unwinding involved in DNA replication
and 2 others

more...

Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 566
Hs

1 719
+ Hs
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+ Dm
+ Dm
+ Dm
+ Dm
+ Dm
+ Sp
+ Sp
+ Sp
+ Sc
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+ Sp

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Last updated: 15 Jul 2024