HitPredict

Interactor 1: MED24 (O75448)
Mediator of RNA polymerase II transcription subunit 24 (Activator-recruited cofactor 100 kDa component) (ARC100) (Cofactor required for Sp1 transcriptional activation subunit 4) (CRSP complex subunit 4) (Mediator complex subunit 24) (Thyroid hormone receptor-associated protein 4) (Thyroid hormone receptor-associated protein complex 100 kDa component) (Trap100) (hTRAP100) (Vitamin D3 receptor-interacting protein complex 100 kDa component) (DRIP100)
Gene: MED24

Interactor 2: SMAD2 (Q15796)
Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2)
Gene: SMAD2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	12167862
Identification Methods	affinity chromatography technology, coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 989 Hs			1 467
+	Hs
		265317 MED24_HUMAN (1-989): 0: 1590: 100.00		SMAD3_HUMAN (1-467): 0: 617: 83.94
+	Hs
		265356 MED24_HUMAN (1-989): 0: 1590: 100.00		SMAD5_HUMAN (1-467): 0: 570: 55.45
+	Hs
		265331 MED24_HUMAN (1-989): 0: 1590: 100.00		SMAD1_HUMAN (1-467): 0: 565: 55.53
+	Hs
		171350 MED24_HUMAN (1-989): 0: 1590: 100.00		SMAD9_HUMAN (1-467): 0: 564: 54.56
+	Hs
		167313 MED24_HUMAN (1-989): 0: 1590: 100.00		SMAD7_HUMAN (13-443): 2.55e-109: 331: 25.23