HitPredict

Interactor 1: PSIP1 (O75475)
PC4 and SFRS1-interacting protein (CLL-associated antigen KW-7) (Dense fine speckles 70 kDa protein) (DFS 70) (Lens epithelium-derived growth factor) (Transcriptional coactivator p75/p52)
Gene: PSIP1

Interactor 2: XRCC6 (P12956)
X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6)
Gene: XRCC6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	30585729, 34349018
Identification Methods	proximity labelling technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 530 Hs			1 609
+	Hs
		523618 MSH6_HUMAN (4-317): 4.4e-58: 211: 15.64		XRCC6_HUMAN (1-609): 0: 666: 100.00
+	Hs
		523798 GLYR1_HUMAN (4-215): 5.73e-35: 139: 20.27		XRCC6_HUMAN (1-609): 0: 666: 100.00
+	Hs
		523614 HDGF_HUMAN (3-225): 5.03e-24: 102: 38.94		XRCC6_HUMAN (1-609): 0: 666: 100.00
+	Hs
		523845 HDGR2_HUMAN (1-521): 2.98e-21: 99.5: 20.73		XRCC6_HUMAN (1-609): 0: 666: 100.00
+	Hs
		524079 ZMYD8_HUMAN (10-490): 5.97e-17: 86.4: 13.32		XRCC6_HUMAN (1-609): 0: 666: 100.00
+	Hs
		523889 THOC2_HUMAN (106-366): 2.25e-09: 62.4: 14.59		XRCC6_HUMAN (1-609): 0: 666: 100.00
+	Hs
		524847 MSH6_HUMAN (4-317): 4.4e-58: 211: 15.64		XRCC5_HUMAN (31-609): 5.27e-125: 387: 16.77
+	Hs
		524845 HDGF_HUMAN (3-225): 5.03e-24: 102: 38.94		XRCC5_HUMAN (31-609): 5.27e-125: 387: 16.77