Protein: KSR1
Kinase suppressor of Ras 1 (EC 2.7.11.1)

Gene: KSR1
Organism: Homo sapiens
Interactions: 128
UniProt ID: Q8IVT5

Gene Ontology (top 5):
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005078 - MAP-kinase scaffold activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

972220

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

8

20

Small-scale

0.969

High

683523

1433B
14-3-3 protein beta/alpha

5

20

High-throughput

0.932

High

734972

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

5

20

Small-scale

0.918

High

904822

1433G
14-3-3 protein gamma

4

20

High-throughput

0.903

High

982244

1433F
14-3-3 protein eta

4

20

High-throughput

0.891

High

647923

MARK3
MAP/microtubule affinity-regulating kinase 3

3

9

Small-scale

0.861

High

878086

ANM2
Protein arginine N-methyltransferase 2

3

4

High-throughput

0.861

High

909779

1433E
14-3-3 protein epsilon

3

11

High-throughput

0.855

High

927270

1433Z
14-3-3 protein zeta/delta

3

20

High-throughput

0.855

High

647085

1433T
14-3-3 protein theta

3

20

High-throughput

0.839

High

374502

RAF1
RAF proto-oncogene serine/threonine-protein kinase

3

18

Small-scale

0.827

High

1203487

SKAP1
Src kinase-associated phosphoprotein 1

2

20

High-throughput

0.789

High

542896

BRAF
Serine/threonine-protein kinase B-raf

2

17

Small-scale

0.776

High

684187

1433S
14-3-3 protein sigma

1

20

High-throughput

0.665

High

1205018

VRK2
Serine/threonine-protein kinase VRK2

1

18

Small-scale

0.665

High

1190810

BRAP
BRCA1-associated protein

3

6

Small-scale

0.662

High

154211

CHK1
Serine/threonine-protein kinase Chk1

1

2

High-throughput

0.618

High

166583

DCLK1
Serine/threonine-protein kinase DCLK1

1

12

High-throughput

0.618

High

230891

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

10

High-throughput

0.618

High

231605

KIF1B
Kinesin-like protein KIF1B

1

9

High-throughput

0.618

High

253378

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

15

High-throughput

0.618

High

719535

MERL
Merlin

1

18

High-throughput

0.618

High

822083

KC1A
Casein kinase I isoform alpha

1

8

High-throughput

0.618

High

960387

CDK16
Cyclin-dependent kinase 16

1

10

High-throughput

0.618

High

1020191

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

20

High-throughput

0.618

High

1022420

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

14

High-throughput

0.618

High

1057178

MELK
Maternal embryonic leucine zipper kinase

1

11

High-throughput

0.618

High

1076893

PTN14
Tyrosine-protein phosphatase non-receptor type 14

1

20

High-throughput

0.618

High

1136462

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

20

High-throughput

0.618

High

1136523

SPD2A
SH3 and PX domain-containing protein 2A

1

10

High-throughput

0.618

High

1153279

PKHA7
Pleckstrin homology domain-containing family A member 7

1

20

High-throughput

0.618

High

1172940

FGD6
FYVE, RhoGEF and PH domain-containing protein 6

1

20

High-throughput

0.618

High

1197808

PHLB2
Pleckstrin homology-like domain family B member 2

1

15

High-throughput

0.618

High

1203937

RGPS2
Ras-specific guanine nucleotide-releasing factor RalGPS2

1

3

High-throughput

0.618

High

1217960

KSR1
Kinase suppressor of Ras 1

1

20

Small-scale

0.618

High

1217962

MILK1
MICAL-like protein 1

1

10

High-throughput

0.618

High

1217966

SH3R3
E3 ubiquitin-protein ligase SH3RF3

1

10

High-throughput

0.618

High

1217975

TESK2
Dual specificity testis-specific protein kinase 2

1

17

High-throughput

0.618

High

1217986

Q9H4D1
Protein kinase

1

20

High-throughput

0.618

High

1217987

PKHA5
Pleckstrin homology domain-containing family A member 5

1

20

High-throughput

0.618

High

1218003

GAB2
GRB2-associated-binding protein 2

1

20

High-throughput

0.618

High

1217981

CAB45
45 kDa calcium-binding protein

2

9

High-throughput

0.611

High

1217982

RTKN
Rhotekin

1

0

High-throughput

0.586

High

1217993

SH3B4
SH3 domain-binding protein 4

1

0

High-throughput

0.586

High

196323

PJA2
E3 ubiquitin-protein ligase Praja-2

1

9

Small-scale

0.578

High

883556

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

20

High-throughput

0.575

High

1217994

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

20

High-throughput

0.553

High

243486

DNJA2
DnaJ homolog subfamily A member 2

1

13

High-throughput

0.536

High

532156

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

5

High-throughput

0.536

High

1217976

TCPQM
T-complex protein 1 subunit theta-like 2

1

16

High-throughput

0.536

High

1217973

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

17

Small-scale

0.501

High

71175

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

7

High-throughput

0.489

High

795987

MAGA8
Melanoma-associated antigen 8

1

4

High-throughput

0.489

High

162956

XPO1
Exportin-1

1

10

High-throughput

0.479

High

196474

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

6

High-throughput

0.479

High

216944

KIF1C
Kinesin-like protein KIF1C

1

9

High-throughput

0.479

High

237259

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

1

High-throughput

0.479

High

264352

GGYF1
GRB10-interacting GYF protein 1

1

4

High-throughput

0.479

High

319253

BRD1
Bromodomain-containing protein 1

1

5

High-throughput

0.479

High

432033

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.479

High

438332

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.479

High

569860

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

598496

NF1
Neurofibromin

1

19

High-throughput

0.479

High

600180

TAF1
Transcription initiation factor TFIID subunit 1

1

8

High-throughput

0.479

High

673495

MPIP2
M-phase inducer phosphatase 2

1

4

High-throughput

0.479

High

673602

MPIP3
M-phase inducer phosphatase 3

1

4

High-throughput

0.479

High

876434

AFAD
Afadin

1

20

High-throughput

0.479

High

880776

HDAC4
Histone deacetylase 4

1

7

High-throughput

0.479

High

997184

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

5

High-throughput

0.479

High

1060563

ZN638
Zinc finger protein 638

1

4

High-throughput

0.479

High

1120136

CRTC2
CREB-regulated transcription coactivator 2

1

7

High-throughput

0.479

High

1139612

DEN4C
DENN domain-containing protein 4C

1

5

High-throughput

0.479

High

1162601

LARP1
La-related protein 1

1

9

High-throughput

0.479

High

1164906

CRTC3
CREB-regulated transcription coactivator 3

1

8

High-throughput

0.479

High

1167919

GGYF2
GRB10-interacting GYF protein 2

1

20

High-throughput

0.479

High

1185252

RFIP2
Rab11 family-interacting protein 2

1

9

High-throughput

0.479

High

1189719

MYCPP
C-myc promoter-binding protein

1

3

High-throughput

0.479

High

1217961

RPTOR
Regulatory-associated protein of mTOR

1

11

High-throughput

0.479

High

1217963

NAV1
Neuron navigator 1

1

9

High-throughput

0.479

High

1217964

F110B
Protein FAM110B

1

1

High-throughput

0.479

High

1217965

DEN1A
DENN domain-containing protein 1A

1

5

High-throughput

0.479

High

1217967

HDAC7
Histone deacetylase 7

1

7

High-throughput

0.479

High

1217969

SRS12
Serine/arginine-rich splicing factor 12

1

11

High-throughput

0.479

High

1217970

ARHG2
Rho guanine nucleotide exchange factor 2

1

16

Small-scale

0.479

High

1217974

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

20

High-throughput

0.479

High

1217979

F110A
Protein FAM110A

1

1

High-throughput

0.479

High

1217984

OSBL6
Oxysterol-binding protein-related protein 6

1

2

High-throughput

0.479

High

1217989

KI13B
Kinesin-like protein KIF13B

1

9

High-throughput

0.479

High

1217990

INP5E
Phosphatidylinositol polyphosphate 5-phosphatase type IV

1

6

High-throughput

0.479

High

1217996

LIMA1
LIM domain and actin-binding protein 1

1

6

High-throughput

0.479

High

1217997

NGAP
Ras GTPase-activating protein nGAP

1

19

High-throughput

0.479

High

1217998

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

3

High-throughput

0.479

High

1217999

ZBT21
Zinc finger and BTB domain-containing protein 21

1

6

High-throughput

0.479

High

1218000

PPM1H
Protein phosphatase 1H

1

3

High-throughput

0.479

High

1218001

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

18

High-throughput

0.479

High

1218002

BAIP2
BAR/IMD domain-containing adapter protein 2

1

19

High-throughput

0.479

High

1218004

HDAC5
Histone deacetylase 5

1

7

High-throughput

0.479

High

1218005

CBY1
Protein chibby homolog 1

1

1

High-throughput

0.479

High

1218006

STA13
StAR-related lipid transfer protein 13

1

13

High-throughput

0.479

High

1218007

DCAF1
DDB1- and CUL4-associated factor 1

1

8

High-throughput

0.479

High

1217977

EBP2
Probable rRNA-processing protein EBP2

1

2

High-throughput

0.470

High

316264

NADK
NAD kinase

1

0

High-throughput

0.458

High

703468

LSP1
Lymphocyte-specific protein 1

1

0

Small-scale

0.458

High

1156235

REEP3
Receptor expression-enhancing protein 3

1

0

High-throughput

0.458

High

1217971

DACT3
Dapper homolog 3

1

0

High-throughput

0.458

High

1217972

EDC3
Enhancer of mRNA-decapping protein 3

1

0

High-throughput

0.458

High

1217978

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

0

High-throughput

0.458

High

1217980

LPIN3
Phosphatidate phosphatase LPIN3

1

0

High-throughput

0.458

High

1217983

PANK2
Pantothenate kinase 2, mitochondrial

1

0

High-throughput

0.458

High

915235

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

11

Small-scale

0.445

High

927841

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

7

Small-scale

0.445

High

1069260

2A5A
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

1

5

Small-scale

0.445

High

1069290

2A5B
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform

1

5

Small-scale

0.445

High

1082521

2A5E
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform

1

5

Small-scale

0.445

High

1109672

TBC25
TBC1 domain family member 25

1

15

High-throughput

0.437

High

1148993

AN34A
Ankyrin repeat domain-containing protein 34A

1

20

High-throughput

0.437

High

1173127

SYDE1
Rho GTPase-activating protein SYDE1

1

18

High-throughput

0.437

High

1198495

TBCD1
TBC1 domain family member 1

1

11

High-throughput

0.437

High

1217968

DEP1B
DEP domain-containing protein 1B

1

9

High-throughput

0.437

High

1217988

TANC2
Protein TANC2

1

17

High-throughput

0.437

High

1217991

CWC25
Pre-mRNA-splicing factor CWC25 homolog

1

2

High-throughput

0.437

High

1217995

CING
Cingulin

1

7

High-throughput

0.437

High

1218008

KCTD3
BTB/POZ domain-containing protein KCTD3

1

1

High-throughput

0.437

High

100930

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

159661

QCR10
Cytochrome b-c1 complex subunit 10

1

0

High-throughput

0.249

Low

1217985

MFR1L
Mitochondrial fission regulator 1-like

1

0

High-throughput

0.249

Low

1217992

FA53C
Protein FAM53C

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024