HitPredict

Interactor 1: PSIP1 (O75475)
PC4 and SFRS1-interacting protein (CLL-associated antigen KW-7) (Dense fine speckles 70 kDa protein) (DFS 70) (Lens epithelium-derived growth factor) (Transcriptional coactivator p75/p52)
Gene: PSIP1

Interactor 2: KMT2B (Q9UMN6)
Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7)
Gene: KMT2B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.594

Property	Details
Experiments	23508102, 23995757
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 530 Hs			1 2715
+	Hs
		1246387 THOC2_HUMAN (106-366): 2.25e-09: 62.4: 14.59		KMT2B_HUMAN (1-2715): 0: 1040: 100.00
+	Hs
		266021 PSIP1_HUMAN (1-530): 1.2e-79: 260: 100.00		EZH2_HUMAN (2246-2697): 1.88e-65: 241: 16.76
+	Hs
		266000 PSIP1_HUMAN (1-530): 1.2e-79: 260: 100.00		KMT2A_HUMAN (1779-2715): 1.14e-53: 212: 30.49
+	Hs
		1071484 ZMY11_HUMAN (9-318): 6.35e-35: 140: 18.01		EZH1_HUMAN (2220-2697): 5.5e-68: 248: 16.70
+	Hs
		1071464 ZMY11_HUMAN (9-318): 6.35e-35: 140: 18.01		EZH2_HUMAN (2246-2697): 1.88e-65: 241: 16.76
+	Hs
		975259 ZMY11_HUMAN (9-318): 6.35e-35: 140: 18.01		KMT2A_HUMAN (1779-2715): 1.14e-53: 212: 30.49
+	Hs
		850929 HDGF_HUMAN (3-225): 5.03e-24: 102: 38.94		EZH2_HUMAN (2246-2697): 1.88e-65: 241: 16.76
+	Hs
		1080075 HDGR2_HUMAN (1-521): 2.98e-21: 99.5: 20.73		EZH2_HUMAN (2246-2697): 1.88e-65: 241: 16.76
+	Mm
		291747 DNM3B_MOUSE (3-196): 2.47e-11: 68.3: 11.17		EZH2_MOUSE (2246-2697): 2.54e-66: 243: 16.76
+	Hs
		850944 HDGF_HUMAN (3-225): 5.03e-24: 102: 38.94		PHF6_HUMAN (1573-1755): 1.92e-32: 133: 19.12