Interactor 1: ERLN1 (O75477)
Erlin-1 (Endoplasmic reticulum lipid raft-associated protein 1) (Protein KE04) (Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1) (SPFH domain-containing protein 1)
Gene: ERLIN1

Interactor 2: ERLN2 (O94905)
Erlin-2 (Endoplasmic reticulum lipid raft-associated protein 2) (Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2) (SPFH domain-containing protein 2)
Gene: ERLIN2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.94 1.00 0.975

The method score is based on:

Property Details
Experiments 21343306, 22119785, 19240031, 22690709, 24217618, 30021884, 33961781, 35235311, 37071682
Identification Methods affinity chromatography technology, proximity labelling technology, cross-linking study, pull down, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Band_7~Band_7
Common GO terms GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0008203 - cholesterol metabolic process
GO:0015485 - cholesterol binding
GO:0031625 - ubiquitin protein ligase binding
and 7 others

more...

Homologous interactions 5

Homologous interactions

Color coding for hit scores

1 348
Hs

1 339
+ Mm
+ Rn
+ Hs
+ Hs
+ Mm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024