HitPredict

Interactor 1: SRS10 (O75494)
Serine/arginine-rich splicing factor 10 (40 kDa SR-repressor protein) (SRrp40) (FUS-interacting serine-arginine-rich protein 1) (Splicing factor SRp38) (Splicing factor, arginine/serine-rich 13A) (TLS-associated protein with Ser-Arg repeats) (TASR) (TLS-associated protein with SR repeats) (TLS-associated serine-arginine protein) (TLS-associated SR protein)
Gene: SRSF10

Interactor 2: PABP1 (P11940)
Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1)
Gene: PABPC1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34316707
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 262 Hs			1 636
+	Hs
		516744 PPIE_HUMAN (10-98): 5.42e-30: 115: 31.46		PABP1_HUMAN (1-636): 0: 582: 100.00
+	Hs
		516466 SRSF3_HUMAN (1-95): 1.17e-25: 100: 35.79		PABP1_HUMAN (1-636): 0: 582: 100.00
+	Hs
		516495 PABP4_HUMAN (2-99): 3.59e-20: 91.3: 18.37		PABP1_HUMAN (1-636): 0: 582: 100.00
+	Hs
		516339 PABP1_HUMAN (2-99): 5.61e-19: 87.9: 17.35		PABP1_HUMAN (1-636): 0: 582: 100.00
+	Hs
		516689 PABP1_HUMAN (2-99): 5.61e-19: 87.9: 17.35		PABP3_HUMAN (1-636): 0: 541: 91.37
+	Sc
		376562 PABP_YEAST (2-98): 4.25e-20: 91: 24.74		PABP_YEAST (2-335): 1.06e-64: 225: 26.71
+	Hs
		267046 SRS10_HUMAN (1-262): 2.41e-34: 126: 100.00		PABP5_HUMAN (6-179): 5.04e-39: 149: 25.26
+	Hs
		680437 SRSF3_HUMAN (1-95): 1.17e-25: 100: 35.79		TIA1_HUMAN (4-172): 1.71e-42: 159: 28.57
+	Hs
		474017 SRSF3_HUMAN (1-95): 1.17e-25: 100: 35.79		PAB4L_HUMAN (187-380): 1.23e-36: 142: 29.74
+	Hs
		516635 PABP1_HUMAN (2-99): 5.61e-19: 87.9: 17.35		PABP5_HUMAN (6-179): 5.04e-39: 149: 25.26
+	Mm
		857332 SRSF2_MOUSE (4-90): 1.89e-24: 99.3: 45.65		TIA1_MOUSE (4-172): 1.01e-34: 137: 27.51
+	Hs
		1119141 PAP1L_HUMAN (6-99): 1.67e-18: 86.3: 21.28		PABP5_HUMAN (6-179): 5.04e-39: 149: 25.26
+	Hs
		474021 PABP4_HUMAN (2-99): 3.59e-20: 91.3: 18.37		PAB4L_HUMAN (187-380): 1.23e-36: 142: 29.74
+	Mm
		665745 PABP1_MOUSE (2-99): 6.34e-19: 87.9: 17.35		TIA1_MOUSE (4-172): 1.01e-34: 137: 27.51
+	Hs
		582561 PPIE_HUMAN (10-98): 5.42e-30: 115: 31.46		NUCL_HUMAN (3-89): 2.56e-19: 94.1: 33.33
+	Hs
		582224 SRSF3_HUMAN (1-95): 1.17e-25: 100: 35.79		NUCL_HUMAN (3-89): 2.56e-19: 94.1: 33.33
+	Hs
		582231 SRSF2_HUMAN (4-90): 1.89e-24: 99.3: 45.65		NUCL_HUMAN (3-89): 2.56e-19: 94.1: 33.33
+	Hs
		516355 PABP1_HUMAN (2-99): 5.61e-19: 87.9: 17.35		NUCL_HUMAN (3-89): 2.56e-19: 94.1: 33.33