Protein: PRGC1
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1-alpha) (PPAR-gamma coactivator 1-alpha) (PPARGC-1-alpha) (Ligand effect modulator 6)

Gene: PRGC1, PPARGC1A
Organism: Homo sapiens
Interactions: 73
UniProt ID: Q9UBK2

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0001659 - temperature homeostasis
GO:0001678 - intracellular glucose homeostasis
GO:0002021 - response to dietary excess
GO:0003677 - DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

789585

PPARG
Peroxisome proliferator-activated receptor gamma

20

20

Small-scale

0.765

High

543597

ERR1
Steroid hormone receptor ERR1

9

20

Small-scale

0.756

High

834078

HNF4A
Hepatocyte nuclear factor 4-alpha

7

19

Small-scale

0.750

High

976929

ERR3
Estrogen-related receptor gamma

6

20

Small-scale

0.732

High

282954

NR1I2
Nuclear receptor subfamily 1 group I member 2

4

20

Small-scale

0.698

High

1025433

CDK6
Cyclin-dependent kinase 6

1

0

Small-scale

0.674

High

137549

NR5A2
Nuclear receptor subfamily 5 group A member 2

3

18

Small-scale

0.640

High

397129

ESR1
Estrogen receptor

3

20

Small-scale

0.637

High

625849

RXRA
Retinoic acid receptor RXR-alpha

2

20

Small-scale

0.628

High

930810

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

1

Small-scale

0.618

High

1033283

EWS
RNA-binding protein EWS

1

1

Small-scale

0.618

High

1062141

SRSF4
Serine/arginine-rich splicing factor 4

1

2

Small-scale

0.618

High

1095474

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

1

Small-scale

0.618

High

1099290

SRSF5
Serine/arginine-rich splicing factor 5

1

2

Small-scale

0.618

High

1099586

SRSF6
Serine/arginine-rich splicing factor 6

1

2

Small-scale

0.618

High

891850

GSK3B
Glycogen synthase kinase-3 beta

1

0

Small-scale

0.614

High

533235

RARB
Retinoic acid receptor beta

2

20

High-throughput

0.606

High

1041803

PPARD
Peroxisome proliferator-activated receptor delta

2

20

Small-scale

0.602

High

1060640

PPARA
Peroxisome proliferator-activated receptor alpha

2

20

Small-scale

0.602

High

404509

GCR
Glucocorticoid receptor

3

20

Small-scale

0.594

High

842009

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

2

Small-scale

0.589

High

655362

SFPQ
Splicing factor, proline- and glutamine-rich

1

0

Small-scale

0.586

High

1029566

SRSF2
Serine/arginine-rich splicing factor 2

1

0

Small-scale

0.586

High

1150837

SF01
Splicing factor 1

1

0

Small-scale

0.586

High

1454674

MYEF2
Myelin expression factor 2

1

0

Small-scale

0.586

High

728458

AKT1
RAC-alpha serine/threonine-protein kinase

1

1

Small-scale

0.575

High

239628

MED14
Mediator of RNA polymerase II transcription subunit 14

1

1

Small-scale

0.561

High

533367

THB
Thyroid hormone receptor beta

1

20

Small-scale

0.561

High

1151304

MED1
Mediator of RNA polymerase II transcription subunit 1

1

2

Small-scale

0.561

High

1155132

USF2
Upstream stimulatory factor 2

1

2

Small-scale

0.561

High

1160996

NRF1
Nuclear respiratory factor 1

1

1

Small-scale

0.561

High

1228218

CR3L3
Cyclic AMP-responsive element-binding protein 3-like protein 3

1

1

Small-scale

0.561

High

1368504

CBP
CREB-binding protein

1

1

Small-scale

0.561

High

1372210

MED12
Mediator of RNA polymerase II transcription subunit 12

1

2

Small-scale

0.561

High

1380226

FBXW7
F-box/WD repeat-containing protein 7

1

1

Small-scale

0.561

High

1388760

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

1

Small-scale

0.561

High

1401346

NR1H4
Bile acid receptor

1

20

Small-scale

0.561

High

414766

P53
Cellular tumor antigen p53

1

0

Small-scale

0.537

High

1153794

NCOA1
Nuclear receptor coactivator 1

1

0

Small-scale

0.537

High

1405696

NECD
Necdin

1

0

Small-scale

0.537

High

1450386

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

Small-scale

0.537

High

832827

BCL6
B-cell lymphoma 6 protein

1

0

Small-scale

0.513

High

467800

MCR
Mineralocorticoid receptor

1

20

Small-scale

0.506

High

648383

USF1
Upstream stimulatory factor 1

1

2

Small-scale

0.501

High

902795

RORG
Nuclear receptor ROR-gamma

1

16

Small-scale

0.501

High

1163257

H2B2E
Histone H2B type 2-E

1

0

High-throughput

0.493

High

1367487

ESR2
Estrogen receptor beta

1

20

High-throughput

0.481

High

992364

SKP1
S-phase kinase-associated protein 1

1

0

Small-scale

0.480

High

993786

UBC9
SUMO-conjugating enzyme UBC9

1

0

Small-scale

0.480

High

1130605

NCOA6
Nuclear receptor coactivator 6

1

0

Small-scale

0.480

High

297700

PIAS1
E3 SUMO-protein ligase PIAS1

1

1

Small-scale

0.479

High

626389

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

1

Small-scale

0.479

High

639320

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

1

Small-scale

0.479

High

848113

NR4A2
Nuclear receptor subfamily 4 group A member 2

1

20

Small-scale

0.479

High

905507

HCFC1
Host cell factor 1

1

1

Small-scale

0.479

High

1045865

TF65
Transcription factor p65

1

1

Small-scale

0.479

High

1067789

EP300
Histone acetyltransferase p300

1

1

Small-scale

0.479

High

1109527

ATR
Serine/threonine-protein kinase ATR

1

1

Small-scale

0.479

High

1126870

NF2L1
Endoplasmic reticulum membrane sensor NFE2L1

1

1

Small-scale

0.479

High

1134814

NR1I3
Nuclear receptor subfamily 1 group I member 3

1

20

Small-scale

0.479

High

1369172

KAT2A
Histone acetyltransferase KAT2A

1

1

Small-scale

0.479

High

1380411

RNF34
E3 ubiquitin-protein ligase RNF34

1

1

Small-scale

0.479

High

412984

CPNS1
Calpain small subunit 1

1

0

High-throughput

0.460

High

250019

OGA
Protein O-GlcNAcase

1

0

Small-scale

0.458

High

363966

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

662667

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

0

Small-scale

0.458

High

714483

PML
Protein PML

1

0

Small-scale

0.458

High

863014

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

0

Small-scale

0.458

High

874010

NRIP1
Nuclear receptor-interacting protein 1

1

0

Small-scale

0.458

High

1108411

MED21
Mediator of RNA polymerase II transcription subunit 21

1

0

Small-scale

0.458

High

1404817

RING2
E3 ubiquitin-protein ligase RING2

1

0

Small-scale

0.458

High

1436786

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

Small-scale

0.458

High

1458434

MED16
Mediator of RNA polymerase II transcription subunit 16

1

0

Small-scale

0.458

High


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Last updated: 11Aug2025