HitPredict

Interactor 1: EED (O75530)
Polycomb protein EED (hEED) (Embryonic ectoderm development protein) (WD protein associating with integrin cytoplasmic tails 1) (WAIT-1)
Gene: EED

Interactor 2: SMCA2 (P51531)
Probable global transcription activator SNF2L2 (EC 3.6.4.-) (ATP-dependent helicase SMARCA2) (BRG1-associated factor 190B) (BAF190B) (Protein brahma homolog) (hBRM) (SNF2-alpha) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2)
Gene: SMARCA2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	24457600
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 441 Hs			1 1590
+	Mm
		1111959 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		SMCA4_MOUSE (40-1588): 0: 986: 72.81
+	Hs
		267962 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		SMCA4_HUMAN (40-1588): 0: 977: 72.70
+	Hs
		847050 FBXW7_HUMAN (219-439): 1.18e-27: 118: 15.32		SMCA4_HUMAN (40-1588): 0: 977: 72.70
+	Mm
		1265290 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		SMCA5_MOUSE (613-1584): 0: 803: 27.51
+	Hs
		229258 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		SMCA5_HUMAN (610-1584): 0: 803: 27.43
+	Mm
		1161361 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		SMCA1_MOUSE (564-1559): 0: 801: 26.50
+	Hs
		267906 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		SMCA1_HUMAN (618-1559): 0: 797: 28.00
+	Hs
		847053 SNR40_HUMAN (298-441): 8.27e-22: 98: 14.29		SMCA4_HUMAN (40-1588): 0: 977: 72.70
+	Hs
		268093 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		CHD4_HUMAN (370-1589): 0: 749: 22.31
+	Mm
		1161077 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		CHD4_MOUSE (370-1589): 0: 740: 22.21
+	Hs
		268053 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		CHD3_HUMAN (415-1590): 0: 725: 23.92
+	Hs
		658714 FBXW7_HUMAN (219-439): 1.18e-27: 118: 15.32		SMCA1_HUMAN (618-1559): 0: 797: 28.00
+	Hs
		658715 SNR40_HUMAN (298-441): 8.27e-22: 98: 14.29		SMCA1_HUMAN (618-1559): 0: 797: 28.00
+	Hs
		1059779 FBXW7_HUMAN (219-439): 1.18e-27: 118: 15.32		CHD4_HUMAN (370-1589): 0: 749: 22.31
+	Hs
		1309165 TBL1Y_HUMAN (277-439): 5.06e-19: 91.1: 13.33		CHD8_HUMAN (19-1359): 0: 741: 21.67
+	Hs
		1254435 FBXW7_HUMAN (219-439): 1.18e-27: 118: 15.32		CHD6_HUMAN (315-1363): 0: 711: 24.12
+	Hs
		903234 WDR5_HUMAN (335-440): 3.22e-14: 75.3: 15.09		CHD4_HUMAN (370-1589): 0: 749: 22.31
+	Hs
		1018633 SNR40_HUMAN (298-441): 8.27e-22: 98: 14.29		CHD3_HUMAN (415-1590): 0: 725: 23.92
+	Hs
		1018714 NLE1_HUMAN (4-124): 2.95e-18: 88.8: 9.09		CHD3_HUMAN (415-1590): 0: 725: 23.92
+	Mm
		57194 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		CHD7_MOUSE (79-693): 1.13e-14: 82.1: 9.19