HitPredict

Interactor 1: SKAP2 (O75563)
Src kinase-associated phosphoprotein 2 (Pyk2/RAFTK-associated protein) (Retinoic acid-induced protein 70) (SKAP55 homolog) (SKAP-55HOM) (SKAP-HOM) (Src family-associated phosphoprotein 2) (Src kinase-associated phosphoprotein 55-related protein) (Src-associated adapter protein with PH and SH3 domains)
Gene: SKAP2

Interactor 2: YES (P07947)
Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes)
Gene: YES1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	29568343
Identification Methods	protein complementation assay
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PH~SH3_1, PK_Tyr_Ser-Thr~SH3_1, SH2~SH3_1, SH3_1~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 359 Hs			1 543
+	Hs
		269517 SKAP2_HUMAN (1-359): 5.4e-121: 355: 100.00		SRC_HUMAN (1-543): 0: 601: 74.22
+	Mm
		763391 SKAP2_MOUSE (1-359): 1.56e-121: 356: 90.53		FYN_MOUSE (1-543): 0: 582: 71.98
+	Hs
		269511 SKAP2_HUMAN (1-359): 5.4e-121: 355: 100.00		FYN_HUMAN (1-543): 0: 582: 72.16
+	Hs
		269515 SKAP2_HUMAN (1-359): 5.4e-121: 355: 100.00		FGR_HUMAN (1-542): 0: 562: 67.10
+	Hs
		269514 SKAP2_HUMAN (1-359): 5.4e-121: 355: 100.00		HCK_HUMAN (1-541): 0: 544: 57.49
+	Hs
		523046 SKAP1_HUMAN (13-359): 1e-98: 298: 42.54		SRC_HUMAN (1-543): 0: 601: 74.22
+	Mm
		411926 SKAP2_MOUSE (1-359): 1.56e-121: 356: 90.53		LCK_MOUSE (83-541): 0: 542: 60.78
+	Hs
		269510 SKAP2_HUMAN (1-359): 5.4e-121: 355: 100.00		LCK_HUMAN (83-541): 0: 540: 60.78
+	Hs
		412249 SKAP1_HUMAN (13-359): 1e-98: 298: 42.54		FYN_HUMAN (1-543): 0: 582: 72.16
+	Mm
		639444 SKAP2_MOUSE (1-359): 1.56e-121: 356: 90.53		LYN_MOUSE (1-541): 1.19e-179: 517: 53.14
+	Hs
		269513 SKAP2_HUMAN (1-359): 5.4e-121: 355: 100.00		LYN_HUMAN (1-541): 3.82e-179: 515: 53.69
+	Hs
		269523 SKAP2_HUMAN (1-359): 5.4e-121: 355: 100.00		BLK_HUMAN (66-538): 5.05e-174: 502: 59.07
+	Hs
		269519 SKAP2_HUMAN (1-359): 5.4e-121: 355: 100.00		FRK_HUMAN (71-535): 1.11e-172: 499: 48.25
+	Hs
		411781 SKAP1_HUMAN (13-359): 1e-98: 298: 42.54		LCK_HUMAN (83-541): 0: 540: 60.78
+	Hs
		269541 SKAP2_HUMAN (1-359): 5.4e-121: 355: 100.00		SRMS_HUMAN (61-534): 7.14e-163: 473: 39.20
+	Hs
		433867 SKAP1_HUMAN (13-359): 1e-98: 298: 42.54		LYN_HUMAN (1-541): 3.82e-179: 515: 53.69
+	Hs
		433388 PKHA7_HUMAN (26-316): 3.97e-42: 159: 14.52		YES_HUMAN (1-543): 0: 617: 100.00
+	Hs
		411764 PKHA7_HUMAN (26-316): 3.97e-42: 159: 14.52		LCK_HUMAN (83-541): 0: 540: 60.78
+	Hs
		411861 PKHA5_HUMAN (27-326): 3.7e-39: 150: 15.86		LCK_HUMAN (83-541): 0: 540: 60.78
+	Hs
		433831 PKHA7_HUMAN (26-316): 3.97e-42: 159: 14.52		LYN_HUMAN (1-541): 3.82e-179: 515: 53.69