Protein: SYTC
Threonine--tRNA ligase 1, cytoplasmic (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS) (Threonyl-tRNA synthetase 1)

Gene: SYTC, TARS1
Organism: Homo sapiens
Interactions: 167
UniProt ID: P26639

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0004829 - threonine-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

60490

SYTC2
Threonine--tRNA ligase 2, cytoplasmic

4

14

High-throughput

0.903

High

240805

PRKN
E3 ubiquitin-protein ligase parkin

3

6

High-throughput

0.640

High

687636

SYTC
Threonine--tRNA ligase 1, cytoplasmic

1

14

High-throughput

0.618

High

687671

CUL3
Cullin-3

2

6

High-throughput

0.611

High

619514

VCAM1
Vascular cell adhesion protein 1

2

3

High-throughput

0.601

High

687644

BRCA1
Breast cancer type 1 susceptibility protein

2

4

High-throughput

0.586

High

461169

HS90A
Heat shock protein HSP 90-alpha

2

9

High-throughput

0.584

High

687690

HUWE1
E3 ubiquitin-protein ligase HUWE1

2

6

High-throughput

0.584

High

687735

RBM27
RNA-binding protein 27

2

2

High-throughput

0.584

High

687683

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

5

High-throughput

0.571

High

135885

P3C2A
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

1

1

High-throughput

0.536

High

213819

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

2

High-throughput

0.536

High

252011

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

1

High-throughput

0.536

High

276064

NIPS2
Protein NipSnap homolog 2

1

2

High-throughput

0.536

High

389053

FINC
Fibronectin

1

3

High-throughput

0.536

High

687652

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

1

2

High-throughput

0.536

High

687664

KPCZ
Protein kinase C zeta type

1

2

High-throughput

0.536

High

687666

AIMP1
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

1

5

High-throughput

0.536

High

687670

CUL1
Cullin-1

1

6

High-throughput

0.536

High

687680

MYLK
Myosin light chain kinase, smooth muscle

1

3

High-throughput

0.536

High

687691

MYLK4
Myosin light chain kinase family member 4

1

2

High-throughput

0.536

High

687724

UBA5
Ubiquitin-like modifier-activating enzyme 5

1

2

High-throughput

0.536

High

687738

AAKG2
5'-AMP-activated protein kinase subunit gamma-2

1

2

High-throughput

0.536

High

687747

SAR1B
Small COPII coat GTPase SAR1B

1

3

High-throughput

0.536

High

259476

BRD4
Bromodomain-containing protein 4

2

2

High-throughput

0.533

High

687717

CG025
UPF0415 protein C7orf25

1

1

High-throughput

0.523

High

415360

HSPB1
Heat shock protein beta-1

1

0

High-throughput

0.518

High

659360

CRCM
Colorectal mutant cancer protein

1

2

High-throughput

0.515

High

687658

ELF3
ETS-related transcription factor Elf-3

1

1

High-throughput

0.515

High

687745

TRAF6
TNF receptor-associated factor 6

1

3

High-throughput

0.515

High

687707

OPTN
Optineurin

1

2

High-throughput

0.515

High

687719

ATGA1
Autophagy-related protein 101

1

0

High-throughput

0.513

High

687645

VHL
von Hippel-Lindau disease tumor suppressor

1

0

High-throughput

0.493

High

687703

NDRG1
Protein NDRG1

1

0

Small-scale

0.493

High

224545

ST1B1
Sulfotransferase 1B1

1

0

High-throughput

0.493

High

687685

C102B
Coiled-coil domain-containing protein 102B

1

2

High-throughput

0.489

High

687708

RMC1
Regulator of MON1-CCZ1 complex

1

1

High-throughput

0.489

High

125249

LEG9
Galectin-9

1

2

High-throughput

0.479

High

176941

CE290
Centrosomal protein of 290 kDa

1

3

High-throughput

0.479

High

258767

DNJA2
DnaJ homolog subfamily A member 2

1

3

High-throughput

0.479

High

269512

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

1

High-throughput

0.479

High

315147

RECQ4
ATP-dependent DNA helicase Q4

1

4

High-throughput

0.479

High

319421

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.479

High

362802

EGFR
Epidermal growth factor receptor

1

2

High-throughput

0.479

High

379882

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

1

High-throughput

0.479

High

408680

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

1

High-throughput

0.479

High

411393

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.479

High

413233

P53
Cellular tumor antigen p53

1

2

High-throughput

0.479

High

425326

ISG15
Ubiquitin-like protein ISG15

1

3

High-throughput

0.479

High

468093

HS90B
Heat shock protein HSP 90-beta

1

9

High-throughput

0.479

High

486979

PARP1
Poly [ADP-ribose] polymerase 1

1

3

High-throughput

0.479

High

565163

ITA4
Integrin alpha-4

1

1

High-throughput

0.479

High

577624

PLAK
Junction plakoglobin

1

1

High-throughput

0.479

High

627595

IF2B
Eukaryotic translation initiation factor 2 subunit 2

1

2

High-throughput

0.479

High

636992

VATB2
V-type proton ATPase subunit B, brain isoform

1

1

High-throughput

0.479

High

667540

CDK2
Cyclin-dependent kinase 2

1

2

High-throughput

0.479

High

679303

DNJB2
DnaJ homolog subfamily B member 2

1

1

High-throughput

0.479

High

680231

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

3

High-throughput

0.479

High

687637

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

687638

PML
Protein PML

1

5

High-throughput

0.479

High

687639

DNJA1
DnaJ homolog subfamily A member 1

1

3

High-throughput

0.479

High

687640

STIP1
Stress-induced-phosphoprotein 1

1

6

High-throughput

0.479

High

687646

CCNF
Cyclin-F

1

4

High-throughput

0.479

High

687647

YAP1
Transcriptional coactivator YAP1

1

10

High-throughput

0.479

High

687649

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

3

High-throughput

0.479

High

687651

MCM2
DNA replication licensing factor MCM2

1

2

High-throughput

0.479

High

687656

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

687659

HSF1
Heat shock factor protein 1

1

1

High-throughput

0.479

High

687661

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

3

High-throughput

0.479

High

687662

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

1

1

High-throughput

0.479

High

687663

1433F
14-3-3 protein eta

1

2

High-throughput

0.479

High

687668

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

687669

PICAL
Phosphatidylinositol-binding clathrin assembly protein

1

1

High-throughput

0.479

High

687672

TRI14
Tripartite motif-containing protein 14

1

1

High-throughput

0.479

High

687673

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

2

High-throughput

0.479

High

687674

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

2

High-throughput

0.479

High

687676

CUL7
Cullin-7

1

1

High-throughput

0.479

High

687679

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

3

High-throughput

0.479

High

687686

VIR
Protein virilizer homolog

1

2

High-throughput

0.479

High

687688

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.479

High

687693

MY18B
Unconventional myosin-XVIIIb

1

1

High-throughput

0.479

High

687696

ARL10
ADP-ribosylation factor-like protein 10

1

3

High-throughput

0.479

High

687697

SERB1
SERPINE1 mRNA-binding protein 1

1

2

High-throughput

0.479

High

687700

TITIN
Titin

1

5

High-throughput

0.479

High

687701

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

1

High-throughput

0.479

High

687702

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

687705

FBXW7
F-box/WD repeat-containing protein 7

1

3

Small-scale

0.479

High

687706

CHM4C
Charged multivesicular body protein 4c

1

2

High-throughput

0.479

High

687710

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

6

Small-scale

0.479

High

687712

CI072
Guanine nucleotide exchange factor C9orf72

1

2

High-throughput

0.479

High

687714

RING2
E3 ubiquitin-protein ligase RING2

1

5

High-throughput

0.479

High

687715

NECD
Necdin

1

1

High-throughput

0.479

High

687716

DNJC7
DnaJ homolog subfamily C member 7

1

5

High-throughput

0.479

High

687721

ACE2
Angiotensin-converting enzyme 2

1

2

High-throughput

0.479

High

687723

TRI55
Tripartite motif-containing protein 55

1

9

High-throughput

0.479

High

687726

DNJC5
DnaJ homolog subfamily C member 5

1

2

High-throughput

0.479

High

687727

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

2

High-throughput

0.479

High

687731

PRD16
Histone-lysine N-methyltransferase PRDM16

1

1

High-throughput

0.479

High

687732

ANLN
Anillin

1

2

High-throughput

0.479

High

687734

WWOX
WW domain-containing oxidoreductase

1

1

High-throughput

0.479

High

687737

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

687739

TRI33
E3 ubiquitin-protein ligase TRIM33

1

3

High-throughput

0.479

High

687740

HDAC5
Histone deacetylase 5

1

4

High-throughput

0.479

High

687744

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

3

High-throughput

0.479

High

687746

YTHD2
YTH domain-containing family protein 2

1

3

High-throughput

0.479

High

294828

BCAR3
Breast cancer anti-estrogen resistance protein 3

1

3

High-throughput

0.470

High

298669

ATP5H
ATP synthase peripheral stalk subunit d, mitochondrial

1

0

High-throughput

0.458

High

402750

CYTB
Cystatin-B

1

0

High-throughput

0.458

High

459465

PROF1
Profilin-1

1

0

High-throughput

0.458

High

570836

MIF
Macrophage migration inhibitory factor

1

0

High-throughput

0.458

High

687641

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

1

0

High-throughput

0.458

High

687643

TALDO
Transaldolase

1

0

High-throughput

0.458

High

687648

RL29
Large ribosomal subunit protein eL29

1

0

High-throughput

0.458

High

687655

RAB2A
Ras-related protein Rab-2A

1

0

High-throughput

0.458

High

687657

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.458

High

687665

TFCP2
Alpha-globin transcription factor CP2

1

0

High-throughput

0.458

High

687667

REST
RE1-silencing transcription factor

1

0

High-throughput

0.458

High

687692

DCP2
m7GpppN-mRNA hydrolase

1

0

High-throughput

0.458

High

687713

TRNT1
CCA tRNA nucleotidyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

687718

DDX50
ATP-dependent RNA helicase DDX50

1

0

High-throughput

0.458

High

687725

ATG5
Autophagy protein 5

1

0

High-throughput

0.458

High

687736

GMPR2
GMP reductase 2

1

0

High-throughput

0.458

High

687743

RL36
Large ribosomal subunit protein eL36

1

0

High-throughput

0.458

High

529127

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.445

High

687653

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

2

High-throughput

0.445

High

687681

NEDD8
Ubiquitin-like protein NEDD8

1

2

Small-scale

0.445

High

687741

ITM2B
Integral membrane protein 2B

1

1

High-throughput

0.445

High

105378

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

142845

NFIB
Nuclear factor 1 B-type

1

1

High-throughput

0.437

High

302754

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

4

High-throughput

0.437

High

352990

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.437

High

371214

MYC
Myc proto-oncogene protein

1

5

High-throughput

0.437

High

384306

CO4A1

1

1

High-throughput

0.437

High

426448

HMGN2
Non-histone chromosomal protein HMG-17

1

1

High-throughput

0.437

High

473799

NFIC
Nuclear factor 1 C-type

1

2

High-throughput

0.437

High

521548

H14
Histone H1.4

1

4

High-throughput

0.437

High

587963

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.437

High

606259

CEBPB
CCAAT/enhancer-binding protein beta

1

4

High-throughput

0.437

High

642635

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

1

High-throughput

0.437

High

687642

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

687660

FKBP3
Peptidyl-prolyl cis-trans isomerase FKBP3

1

6

High-throughput

0.437

High

687675

RBM39
RNA-binding protein 39

1

2

High-throughput

0.437

High

687677

HAPR1
HUWE1-associated protein modifying stress responses 1

1

1

High-throughput

0.437

High

687682

GON4L
GON-4-like protein

1

1

High-throughput

0.437

High

687684

OTUD1
OTU domain-containing protein 1

1

1

High-throughput

0.437

High

687687

LMBRL
Protein LMBR1L

1

2

High-throughput

0.437

High

687689

MOB3C
MOB kinase activator 3C

1

1

High-throughput

0.437

High

687694

DJC10
DnaJ homolog subfamily C member 10

1

5

High-throughput

0.437

High

687695

RHG24
Rho GTPase-activating protein 24

1

1

High-throughput

0.437

High

687699

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

1

High-throughput

0.437

High

687704

HDAC2
Histone deacetylase 2

1

2

High-throughput

0.437

High

687722

YTHD1
YTH domain-containing family protein 1

1

3

High-throughput

0.437

High

687729

PKHA4
Pleckstrin homology domain-containing family A member 4

1

7

High-throughput

0.437

High

687742

AAR2
Protein AAR2 homolog

1

1

High-throughput

0.437

High

687709

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.426

High

429337

JUN
Transcription factor Jun

1

8

High-throughput

0.407

High

687730

VIAAT
Vesicular inhibitory amino acid transporter

1

1

High-throughput

0.407

High

687650

CEBPA
CCAAT/enhancer-binding protein alpha

1

3

High-throughput

0.373

High

687720

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.279

Low

239732

PCDH7
Protocadherin-7

1

0

High-throughput

0.249

Low

687678

HERP1
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

1

0

High-throughput

0.249

Low

687698

S35B2
Adenosine 3'-phospho 5'-phosphosulfate transporter 1

1

0

High-throughput

0.249

Low

687728

SENP3
Sentrin-specific protease 3

1

0

Small-scale

0.249

Low

687733

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

0

High-throughput

0.249

Low

687654

DSCR9
Down syndrome critical region protein 9

1

0

High-throughput

0.238

Low

687711

S45A3
Solute carrier family 45 member 3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025