HitPredict

Interactor 1: KS6A4 (O75676)
Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (Ribosomal protein kinase B) (RSKB)
Gene: RPS6KA4

Interactor 2: CSK2B (P67870)
Casein kinase II subunit beta (CK II beta) (Phosvitin) (Protein G5a)
Gene: CSNK2B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	33961781, 32707033
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CK_II_beta~Pkinase
Common GO terms	GO:0004674 - protein serine/threonine kinase activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 772 Hs			1 215
+	Hs
		270398 KS6A5_HUMAN (2-772): 0: 765: 59.38		CSK2B_HUMAN (1-215): 2.27e-138: 387: 100.00
+	Hs
		850634 KS6A3_HUMAN (1-740): 0: 703: 41.21		CSK2B_HUMAN (1-215): 2.27e-138: 387: 100.00
+	Hs
		931650 KS6A1_HUMAN (3-739): 0: 701: 40.79		CSK2B_HUMAN (1-215): 2.27e-138: 387: 100.00
+	Hs
		616695 KS6B1_HUMAN (371-771): 4.57e-113: 354: 22.75		CSK2B_HUMAN (1-215): 2.27e-138: 387: 100.00
+	Hs
		931918 KS6B2_HUMAN (411-771): 2.6e-113: 354: 23.82		CSK2B_HUMAN (1-215): 2.27e-138: 387: 100.00
+	Dm
		437155 Q9VR61_DROME (403-770): 1.6e-99: 330: 22.98		CSK2B_DROME (1-215): 1.94e-134: 378: 88.37
+	Hs
		931649 KS6A2_HUMAN (3-301): 4.68e-89: 297: 23.86		CSK2B_HUMAN (1-215): 2.27e-138: 387: 100.00
+	Sc
		515193 SCH9_YEAST (417-663): 8.06e-25: 112: 31.01		CSK2B_YEAST (2-196): 7.6e-84: 251: 39.66