HitPredict

Interactor 1: GRAP2 (O75791)
GRB2-related adapter protein 2 (Adapter protein GRID) (GRB-2-like protein) (GRB2L) (GRBLG) (GRBX) (Grf40 adapter protein) (Grf-40) (Growth factor receptor-binding protein) (Hematopoietic cell-associated adapter protein GrpL) (P38) (Protein GADS) (SH3-SH2-SH3 adapter Mona)
Gene: GRAP2

Interactor 2: LATS2 (Q9NRM7)
Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase)
Gene: LATS2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.560

Property	Details
Experiments	27107012
Identification Methods	two hybrid, barcode fusion genetics two hybrid, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 330 Hs			1 1088
+	Hs
		789133 FRK_HUMAN (4-136): 3.57e-53: 184: 32.67		LATS2_HUMAN (1-1088): 0: 983: 100.00
+	Hs
		337568 ABL1_HUMAN (4-134): 1.36e-50: 182: 36.23		LATS2_HUMAN (1-1088): 0: 983: 100.00
+	Hs
		411727 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		STK38_HUMAN (583-1065): 5.24e-146: 447: 40.58
+	Mm
		411915 LCK_MOUSE (3-136): 1.79e-53: 184: 34.46		KPCE_MOUSE (554-1010): 2.84e-130: 415: 29.92
+	Hs
		802606 CRK_HUMAN (46-330): 1.14e-34: 130: 18.87		STK38_HUMAN (583-1065): 5.24e-146: 447: 40.58
+	Hs
		580944 PLCG1_HUMAN (24-328): 1.98e-33: 132: 16.08		AKT1_HUMAN (532-1043): 2.2e-141: 435: 22.16
+	Hs
		580979 PLCG1_HUMAN (24-328): 1.98e-33: 132: 16.08		KPCE_HUMAN (554-1010): 1.06e-129: 413: 29.92
+	Hs
		433510 YES_HUMAN (198-327): 2.27e-21: 96.4: 21.97		ST38L_HUMAN (592-1051): 1.3e-146: 448: 41.30
+	Hs
		568579 CRK_HUMAN (46-330): 1.14e-34: 130: 18.87		KAPCA_HUMAN (635-1024): 1.31e-133: 410: 31.73
+	Hs
		412046 FYN_HUMAN (222-329): 3.95e-22: 98.7: 30.00		AKT1_HUMAN (532-1043): 2.2e-141: 435: 22.16
+	Hs
		1377229 CD2AP_HUMAN (280-330): 4.65e-16: 81: 34.62		ST38L_HUMAN (592-1051): 1.3e-146: 448: 41.30
+	Hs
		681710 CSK_HUMAN (2-136): 2.34e-17: 84.3: 30.41		AKT1_HUMAN (532-1043): 2.2e-141: 435: 22.16
+	Hs
		682092 CD2AP_HUMAN (280-330): 4.65e-16: 81: 34.62		AKT1_HUMAN (532-1043): 2.2e-141: 435: 22.16
+	Hs
		411994 FYN_HUMAN (222-329): 3.95e-22: 98.7: 30.00		KAPCA_HUMAN (635-1024): 1.31e-133: 410: 31.73
+	Hs
		412014 FYN_HUMAN (222-329): 3.95e-22: 98.7: 30.00		KAPCB_HUMAN (638-1022): 1.92e-133: 410: 31.36
+	Hs
		411758 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		MRCKA_HUMAN (656-1007): 6.11e-76: 277: 41.23
+	Hs
		789116 FRK_HUMAN (4-136): 3.57e-53: 184: 32.67		KS6A1_HUMAN (519-977): 1.47e-79: 277: 20.34
+	Hs
		411908 LCK_HUMAN (3-136): 1.04e-53: 185: 34.46		MRCKB_HUMAN (658-1007): 1.11e-70: 261: 40.34
+	Hs
		412095 FYN_HUMAN (222-329): 3.95e-22: 98.7: 30.00		KS6A3_HUMAN (519-990): 8.69e-81: 281: 19.63
+	Hs
		412205 FYN_HUMAN (222-329): 3.95e-22: 98.7: 30.00		KS6A1_HUMAN (519-977): 1.47e-79: 277: 20.34